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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
TKTL1
Full Name:
Transketolase-like protein 1
Alias:
EC 2.2.1.1; TK 2; TKR; TKT2; Transketolase 2; Transketolase-like 1; Transketolase-related protein
Type:
Carbohydrate Metabolism - pentose phosphate pathway; EC 2.2.1.1; Transferase
Mass (Da):
65333
Number AA:
596
UniProt ID:
P51854
International Prot ID:
IPI00439749
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0005509
GO:0004802
PhosphoSite+
KinaseNET
Biological Process:
GO:0006007
GO:0006772
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T20
E
A
R
P
D
R
G
T
L
Q
V
L
Q
D
M
Site 2
S29
Q
V
L
Q
D
M
A
S
R
L
R
I
H
S
I
Site 3
S35
A
S
R
L
R
I
H
S
I
R
A
T
C
S
T
Site 4
T39
R
I
H
S
I
R
A
T
C
S
T
S
S
G
H
Site 5
S41
H
S
I
R
A
T
C
S
T
S
S
G
H
P
T
Site 6
T42
S
I
R
A
T
C
S
T
S
S
G
H
P
T
S
Site 7
S43
I
R
A
T
C
S
T
S
S
G
H
P
T
S
C
Site 8
S44
R
A
T
C
S
T
S
S
G
H
P
T
S
C
S
Site 9
T48
S
T
S
S
G
H
P
T
S
C
S
S
S
S
E
Site 10
S49
T
S
S
G
H
P
T
S
C
S
S
S
S
E
I
Site 11
S51
S
G
H
P
T
S
C
S
S
S
S
E
I
M
S
Site 12
S52
G
H
P
T
S
C
S
S
S
S
E
I
M
S
V
Site 13
S53
H
P
T
S
C
S
S
S
S
E
I
M
S
V
L
Site 14
Y67
L
F
F
Y
I
M
R
Y
K
Q
S
D
P
E
N
Site 15
S70
Y
I
M
R
Y
K
Q
S
D
P
E
N
P
D
N
Site 16
Y112
G
M
A
Y
T
G
K
Y
F
D
R
A
S
Y
R
Site 17
Y118
K
Y
F
D
R
A
S
Y
R
V
F
C
L
M
S
Site 18
S125
Y
R
V
F
C
L
M
S
D
G
E
S
S
E
G
Site 19
S129
C
L
M
S
D
G
E
S
S
E
G
S
V
W
E
Site 20
S133
D
G
E
S
S
E
G
S
V
W
E
A
M
A
F
Site 21
Y173
A
E
H
C
I
N
I
Y
Q
R
R
C
E
A
F
Site 22
Y185
E
A
F
G
W
N
T
Y
V
V
D
G
R
D
V
Site 23
T216
P
T
A
V
V
A
K
T
F
K
G
R
G
T
P
Site 24
T222
K
T
F
K
G
R
G
T
P
S
I
E
D
A
E
Site 25
S230
P
S
I
E
D
A
E
S
W
H
A
K
P
M
P
Site 26
S250
A
I
I
K
L
I
E
S
Q
I
Q
T
S
R
N
Site 27
T254
L
I
E
S
Q
I
Q
T
S
R
N
L
D
P
Q
Site 28
S267
P
Q
P
P
I
E
D
S
P
E
V
N
I
T
D
Site 29
T273
D
S
P
E
V
N
I
T
D
V
R
M
T
S
P
Site 30
T278
N
I
T
D
V
R
M
T
S
P
P
D
Y
R
V
Site 31
S279
I
T
D
V
R
M
T
S
P
P
D
Y
R
V
G
Site 32
Y283
R
M
T
S
P
P
D
Y
R
V
G
D
K
I
A
Site 33
T316
V
V
V
L
D
G
D
T
R
Y
S
T
F
S
E
Site 34
Y318
V
L
D
G
D
T
R
Y
S
T
F
S
E
I
F
Site 35
S319
L
D
G
D
T
R
Y
S
T
F
S
E
I
F
N
Site 36
T320
D
G
D
T
R
Y
S
T
F
S
E
I
F
N
K
Site 37
S322
D
T
R
Y
S
T
F
S
E
I
F
N
K
E
Y
Site 38
Y329
S
E
I
F
N
K
E
Y
P
E
R
F
I
E
C
Site 39
S401
S
V
G
D
D
G
A
S
Q
M
A
L
E
D
I
Site 40
T423
K
C
T
I
F
Y
P
T
D
A
V
S
T
E
H
Site 41
T446
K
G
M
C
F
I
R
T
T
R
P
E
T
M
V
Site 42
T451
I
R
T
T
R
P
E
T
M
V
I
Y
T
P
Q
Site 43
Y455
R
P
E
T
M
V
I
Y
T
P
Q
E
R
F
E
Site 44
T456
P
E
T
M
V
I
Y
T
P
Q
E
R
F
E
I
Site 45
T532
A
T
E
G
R
I
I
T
V
E
D
H
Y
P
Q
Site 46
Y537
I
I
T
V
E
D
H
Y
P
Q
G
G
I
G
E
Site 47
S564
Q
V
H
S
L
A
V
S
G
V
P
Q
S
G
K
Site 48
S569
A
V
S
G
V
P
Q
S
G
K
S
E
E
L
L
Site 49
S572
G
V
P
Q
S
G
K
S
E
E
L
L
D
M
Y
Site 50
Y579
S
E
E
L
L
D
M
Y
G
I
S
A
R
H
I
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation