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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
AKR1D1
Full Name:
3-oxo-5-beta-steroid 4-dehydrogenase
Alias:
Aldo-keto reductase family 1 member D1;Delta(4)-3-ketosteroid 5-beta-reductase;Delta(4)-3-oxosteroid 5-beta-reductase
Type:
Mass (Da):
37377
Number AA:
326
UniProt ID:
P51857
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S7
_
M
D
L
S
A
A
S
H
R
I
P
L
S
D
Site 2
S13
A
S
H
R
I
P
L
S
D
G
N
S
I
P
I
Site 3
Y26
P
I
I
G
L
G
T
Y
S
E
P
K
S
T
P
Site 4
S27
I
I
G
L
G
T
Y
S
E
P
K
S
T
P
K
Site 5
S31
G
T
Y
S
E
P
K
S
T
P
K
G
A
C
A
Site 6
T32
T
Y
S
E
P
K
S
T
P
K
G
A
C
A
T
Site 7
Y49
K
V
A
I
D
T
G
Y
R
H
I
D
G
A
Y
Site 8
Y56
Y
R
H
I
D
G
A
Y
I
Y
Q
N
E
H
E
Site 9
Y58
H
I
D
G
A
Y
I
Y
Q
N
E
H
E
V
G
Site 10
Y84
V
R
R
E
D
I
F
Y
C
G
K
L
W
A
T
Site 11
T101
V
P
E
M
V
R
P
T
L
E
R
T
L
R
V
Site 12
T105
V
R
P
T
L
E
R
T
L
R
V
L
Q
L
D
Site 13
Y132
F
K
P
G
D
E
I
Y
P
R
D
E
N
G
K
Site 14
Y142
D
E
N
G
K
W
L
Y
H
K
S
N
L
C
A
Site 15
S165
K
D
A
G
L
V
K
S
L
G
V
S
N
F
N
Site 16
S169
L
V
K
S
L
G
V
S
N
F
N
R
R
Q
L
Site 17
S191
G
L
K
H
K
P
V
S
N
Q
V
E
C
H
P
Site 18
Y199
N
Q
V
E
C
H
P
Y
F
T
Q
P
K
L
L
Site 19
Y219
H
D
I
V
I
T
A
Y
S
P
L
G
T
S
R
Site 20
S220
D
I
V
I
T
A
Y
S
P
L
G
T
S
R
N
Site 21
T224
T
A
Y
S
P
L
G
T
S
R
N
P
I
W
V
Site 22
S225
A
Y
S
P
L
G
T
S
R
N
P
I
W
V
N
Site 23
S234
N
P
I
W
V
N
V
S
S
P
P
L
L
K
D
Site 24
S246
L
K
D
A
L
L
N
S
L
G
K
R
Y
N
K
Site 25
T254
L
G
K
R
Y
N
K
T
A
A
Q
I
V
L
R
Site 26
S290
N
F
Q
I
F
D
F
S
L
T
E
E
E
M
K
Site 27
Y326
E
Y
P
F
H
D
E
Y
_
_
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation