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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
Cyclin H
Full Name:
Cyclin-H
Alias:
CCNH; MO15-associated protein; p34; p37
Type:
Protein-serine kinase regulatory subunit, activator, cyclin
Mass (Da):
37643
Number AA:
323
UniProt ID:
P51946
International Prot ID:
IPI00021305
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0019907
GO:0005675
Uniprot
OncoNet
Molecular Function:
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0006368
GO:0007049
GO:0000718
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S5
_
_
_
M
Y
H
N
S
S
Q
K
R
H
W
T
Site 2
T12
S
S
Q
K
R
H
W
T
F
S
S
E
E
Q
L
Site 3
S14
Q
K
R
H
W
T
F
S
S
E
E
Q
L
A
R
Site 4
T55
L
E
P
H
E
E
M
T
L
C
K
Y
Y
E
K
Site 5
Y59
E
E
M
T
L
C
K
Y
Y
E
K
R
L
L
E
Site 6
Y60
E
M
T
L
C
K
Y
Y
E
K
R
L
L
E
F
Site 7
Y99
L
N
N
S
V
M
E
Y
H
P
R
I
I
M
L
Site 8
S121
K
V
D
E
F
N
V
S
S
P
Q
F
V
G
N
Site 9
S122
V
D
E
F
N
V
S
S
P
Q
F
V
G
N
L
Site 10
S132
F
V
G
N
L
R
E
S
P
L
G
Q
E
K
A
Site 11
Y164
H
L
I
V
H
N
P
Y
R
P
F
E
G
F
L
Site 12
T176
G
F
L
I
D
L
K
T
R
Y
P
I
L
E
N
Site 13
Y178
L
I
D
L
K
T
R
Y
P
I
L
E
N
P
E
Site 14
T190
N
P
E
I
L
R
K
T
A
D
D
F
L
N
R
Site 15
S230
R
A
G
I
T
M
E
S
Y
L
S
E
S
L
M
Site 16
S233
I
T
M
E
S
Y
L
S
E
S
L
M
L
K
E
Site 17
T243
L
M
L
K
E
N
R
T
C
L
S
Q
L
L
D
Site 18
S246
K
E
N
R
T
C
L
S
Q
L
L
D
I
M
K
Site 19
S254
Q
L
L
D
I
M
K
S
M
R
N
L
V
K
K
Site 20
Y262
M
R
N
L
V
K
K
Y
E
P
P
R
S
E
E
Site 21
S267
K
K
Y
E
P
P
R
S
E
E
V
A
V
L
K
Site 22
S282
Q
K
L
E
R
C
H
S
A
E
L
A
L
N
V
Site 23
Y297
I
T
K
K
R
K
G
Y
E
D
D
D
Y
V
S
Site 24
Y302
K
G
Y
E
D
D
D
Y
V
S
K
K
S
K
H
Site 25
S304
Y
E
D
D
D
Y
V
S
K
K
S
K
H
E
E
Site 26
S307
D
D
Y
V
S
K
K
S
K
H
E
E
E
E
W
Site 27
T315
K
H
E
E
E
E
W
T
D
D
D
L
V
E
S
Site 28
S322
T
D
D
D
L
V
E
S
L
_
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation