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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PGD
Full Name:
6-phosphogluconate dehydrogenase, decarboxylating
Alias:
6PGD; 6-phosphogluconate dehydrogenase; EC 1.1.1.44; PGDH; Phosphogluconate dehydrogenase
Type:
Other Amino Acids Metabolism - glutathione; Oxidoreductase; EC 1.1.1.44; Carbohydrate Metabolism - pentose phosphate pathway
Mass (Da):
53140
Number AA:
483
UniProt ID:
P52209
International Prot ID:
IPI00219525
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
Uniprot
OncoNet
Molecular Function:
GO:0050661
GO:0004616
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0055114
GO:0009051
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S37
C
A
F
N
R
T
V
S
K
V
D
D
F
L
A
Site 2
T50
L
A
N
E
A
K
G
T
K
V
V
G
A
Q
S
Site 3
S57
T
K
V
V
G
A
Q
S
L
K
E
M
V
S
K
Site 4
S63
Q
S
L
K
E
M
V
S
K
L
K
K
P
R
R
Site 5
T109
G
N
S
E
Y
R
D
T
T
R
R
C
R
D
L
Site 6
T110
N
S
E
Y
R
D
T
T
R
R
C
R
D
L
K
Site 7
S129
L
F
V
G
S
G
V
S
G
G
E
E
G
A
R
Site 8
Y137
G
G
E
E
G
A
R
Y
G
P
S
L
M
P
G
Site 9
S140
E
G
A
R
Y
G
P
S
L
M
P
G
G
N
K
Site 10
T226
A
F
E
D
W
N
K
T
E
L
D
S
F
L
I
Site 11
S230
W
N
K
T
E
L
D
S
F
L
I
E
I
T
A
Site 12
T245
N
I
L
K
F
Q
D
T
D
G
K
H
L
L
P
Site 13
S257
L
L
P
K
I
R
D
S
A
G
Q
K
G
T
G
Site 14
T263
D
S
A
G
Q
K
G
T
G
K
W
T
A
I
S
Site 15
T267
Q
K
G
T
G
K
W
T
A
I
S
A
L
E
Y
Site 16
S270
T
G
K
W
T
A
I
S
A
L
E
Y
G
V
P
Site 17
S292
V
F
A
R
C
L
S
S
L
K
D
E
R
I
Q
Site 18
S318
Q
F
D
G
D
K
K
S
F
L
E
D
I
R
K
Site 19
Y328
E
D
I
R
K
A
L
Y
A
S
K
I
I
S
Y
Site 20
S397
L
L
D
D
F
F
K
S
A
V
E
N
C
Q
D
Site 21
S405
A
V
E
N
C
Q
D
S
W
R
R
A
V
S
T
Site 22
S411
D
S
W
R
R
A
V
S
T
G
V
Q
A
G
I
Site 23
T412
S
W
R
R
A
V
S
T
G
V
Q
A
G
I
P
Site 24
Y433
A
L
S
F
Y
D
G
Y
R
H
E
M
L
P
A
Site 25
S441
R
H
E
M
L
P
A
S
L
I
Q
A
Q
R
D
Site 26
Y449
L
I
Q
A
Q
R
D
Y
F
G
A
H
T
Y
E
Site 27
T470
Q
F
I
H
T
N
W
T
G
H
G
G
T
V
S
Site 28
T475
N
W
T
G
H
G
G
T
V
S
S
S
S
Y
N
Site 29
S477
T
G
H
G
G
T
V
S
S
S
S
Y
N
A
_
Site 30
S478
G
H
G
G
T
V
S
S
S
S
Y
N
A
_
_
Site 31
S479
H
G
G
T
V
S
S
S
S
Y
N
A
_
_
_
Site 32
S480
G
G
T
V
S
S
S
S
Y
N
A
_
_
_
_
Site 33
Y481
G
T
V
S
S
S
S
Y
N
A
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation