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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
KPNA2
Full Name:
Importin subunit alpha-2
Alias:
IMA2; Importin alpha-2 subunit; Karyopherin subunit alpha-2; RAG cohort protein 1; RCH1; SRP1; SRP1-alpha
Type:
Nucleopore protein
Mass (Da):
57862
Number AA:
529
UniProt ID:
P52292
International Prot ID:
IPI00002214
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005643
GO:0005654
Uniprot
OncoNet
Molecular Function:
GO:0042826
GO:0008139
GO:0008565
PhosphoSite+
KinaseNET
Biological Process:
GO:0006259
GO:0000085
GO:0000072
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S2
_
_
_
_
_
_
M
S
T
N
E
N
A
N
T
Site 2
T9
S
T
N
E
N
A
N
T
P
A
A
R
L
H
R
Site 3
S24
F
K
N
K
G
K
D
S
T
E
M
R
R
R
R
Site 4
T25
K
N
K
G
K
D
S
T
E
M
R
R
R
R
I
Site 5
S54
M
L
K
R
R
N
V
S
S
F
P
D
D
A
T
Site 6
S55
L
K
R
R
N
V
S
S
F
P
D
D
A
T
S
Site 7
T61
S
S
F
P
D
D
A
T
S
P
L
Q
E
N
R
Site 8
S62
S
F
P
D
D
A
T
S
P
L
Q
E
N
R
N
Site 9
T73
E
N
R
N
N
Q
G
T
V
N
W
S
V
D
D
Site 10
S87
D
I
V
K
G
I
N
S
S
N
V
E
N
Q
L
Site 11
S88
I
V
K
G
I
N
S
S
N
V
E
N
Q
L
Q
Site 12
S105
Q
A
A
R
K
L
L
S
R
E
K
Q
P
P
I
Site 13
S126
G
L
I
P
K
F
V
S
F
L
G
R
T
D
C
Site 14
S134
F
L
G
R
T
D
C
S
P
I
Q
F
E
S
A
Site 15
S149
W
A
L
T
N
I
A
S
G
T
S
E
Q
T
K
Site 16
Y203
F
R
D
L
V
I
K
Y
G
A
V
D
P
L
L
Site 17
Y225
M
S
S
L
A
C
G
Y
L
R
N
L
T
W
T
Site 18
T232
Y
L
R
N
L
T
W
T
L
S
N
L
C
R
N
Site 19
Y277
D
T
C
W
A
I
S
Y
L
T
D
G
P
N
E
Site 20
T311
A
S
E
L
P
I
V
T
P
A
L
R
A
I
G
Site 21
T328
V
T
G
T
D
E
Q
T
Q
V
V
I
D
A
G
Site 22
T349
S
L
L
T
N
P
K
T
N
I
Q
K
E
A
T
Site 23
T358
I
Q
K
E
A
T
W
T
M
S
N
I
T
A
G
Site 24
S360
K
E
A
T
W
T
M
S
N
I
T
A
G
R
Q
Site 25
T393
L
S
K
A
D
F
K
T
Q
K
E
A
V
W
A
Site 26
S461
L
G
E
T
E
K
L
S
I
M
I
E
E
C
G
Site 27
S488
N
E
S
V
Y
K
A
S
L
S
L
I
E
K
Y
Site 28
S490
S
V
Y
K
A
S
L
S
L
I
E
K
Y
F
S
Site 29
Y495
S
L
S
L
I
E
K
Y
F
S
V
E
E
E
E
Site 30
S497
S
L
I
E
K
Y
F
S
V
E
E
E
E
D
Q
Site 31
T516
E
T
T
S
E
G
Y
T
F
Q
V
Q
D
G
A
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation