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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
KPNA1
Full Name:
Importin subunit alpha-1
Alias:
IMA1; Importin alpha 5; Importin alpha S1; IPOA5; Karyopherin alpha 1; Karyopherin alpha-1 subunit; Karyopherin subunit alpha-1; NPI-1; Nucleoprotein interactor 1; RAG cohort protein 2; RCH2; SRP1; SRP1-beta
Type:
Adaptor/scaffold; Karyopherin
Mass (Da):
60249
Number AA:
538
UniProt ID:
P52294
International Prot ID:
IPI00303292
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005829
GO:0005643
GO:0005654
Uniprot
OncoNet
Molecular Function:
GO:0008139
GO:0005515
GO:0008565
PhosphoSite+
KinaseNET
Biological Process:
GO:0006607
GO:0044419
GO:0000018
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T2
_
_
_
_
_
_
M
T
T
P
G
K
E
N
F
Site 2
S13
K
E
N
F
R
L
K
S
Y
K
N
K
S
L
N
Site 3
Y14
E
N
F
R
L
K
S
Y
K
N
K
S
L
N
P
Site 4
S18
L
K
S
Y
K
N
K
S
L
N
P
D
E
M
R
Site 5
T52
F
K
R
R
N
V
A
T
A
E
E
E
T
E
E
Site 6
S63
E
T
E
E
E
V
M
S
D
G
G
F
H
E
A
Site 7
S93
D
M
I
E
M
I
F
S
K
S
P
E
Q
Q
L
Site 8
S95
I
E
M
I
F
S
K
S
P
E
Q
Q
L
S
A
Site 9
S101
K
S
P
E
Q
Q
L
S
A
T
Q
K
F
R
K
Site 10
S111
Q
K
F
R
K
L
L
S
K
E
P
N
P
P
I
Site 11
T142
L
K
R
K
E
N
C
T
L
Q
F
E
S
A
W
Site 12
S156
W
V
L
T
N
I
A
S
G
N
S
L
Q
T
R
Site 13
T201
G
N
I
A
G
D
S
T
M
C
R
D
Y
V
L
Site 14
S221
P
P
L
L
Q
L
F
S
K
Q
N
R
L
T
M
Site 15
T227
F
S
K
Q
N
R
L
T
M
T
R
N
A
V
W
Site 16
S244
S
N
L
C
R
G
K
S
P
P
P
E
F
A
K
Site 17
S279
A
D
A
C
W
A
L
S
Y
L
S
D
G
P
N
Site 18
Y280
D
A
C
W
A
L
S
Y
L
S
D
G
P
N
D
Site 19
S314
H
N
D
Y
K
V
V
S
P
A
L
R
A
V
G
Site 20
S348
Q
S
L
L
H
L
L
S
S
P
K
E
S
I
K
Site 21
S349
S
L
L
H
L
L
S
S
P
K
E
S
I
K
K
Site 22
S353
L
L
S
S
P
K
E
S
I
K
K
E
A
C
W
Site 23
T361
I
K
K
E
A
C
W
T
I
S
N
I
T
A
G
Site 24
T391
A
L
I
S
I
L
Q
T
A
E
F
R
T
R
K
Site 25
T396
L
Q
T
A
E
F
R
T
R
K
E
A
A
W
A
Site 26
S409
W
A
I
T
N
A
T
S
G
G
S
A
E
Q
I
Site 27
T463
Q
E
A
K
R
N
G
T
G
I
N
P
Y
C
A
Site 28
Y468
N
G
T
G
I
N
P
Y
C
A
L
I
E
E
A
Site 29
Y476
C
A
L
I
E
E
A
Y
G
L
D
K
I
E
F
Site 30
Y493
S
H
E
N
Q
E
I
Y
Q
K
A
F
D
L
I
Site 31
Y503
A
F
D
L
I
E
H
Y
F
G
T
E
D
E
D
Site 32
S511
F
G
T
E
D
E
D
S
S
I
A
P
Q
V
D
Site 33
S512
G
T
E
D
E
D
S
S
I
A
P
Q
V
D
L
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation