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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
JAK3
Full Name:
Tyrosine-protein kinase JAK3
Alias:
EC 2.7.10.2; JAK-3; JAK3_HUMAN; JAKL; Janus kinase 3; Kinase Jak3; Leukocyte janus kinase; LJAK; L-JAK
Type:
EC 2.7.10.2; Protein kinase, tyrosine (non-receptor); TK group; JakA family
Mass (Da):
125099
Number AA:
1124
UniProt ID:
P52333
International Prot ID:
IPI00219417
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005856
GO:0019898
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0004718
GO:0004715
PhosphoSite+
KinaseNET
Biological Process:
GO:0018108
GO:0007243
Phosida
TranscriptoNet
STRING
Kinexus Products
Janus protein-tyrosine kinase 3 pan-specific antibody AB-NK086-2#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-NK086-2#Janus protein-tyrosine kinase 3 pan-specific antibody AB-NK086-3#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-NK086-3#Janus protein-tyrosine kinase 3 pan-specific antibody AB-NK086-4#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-NK086-4#Janus protein-tyrosine kinase 3 Y980+Y981 phosphosite-specific antibody AB-PK669#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-PK669#Janus protein-tyrosine kinase 3 (M1-C16, human) peptide - Powder PE-01AUP99#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-01AUP99#Janus protein-tyrosine kinase 3 (D1084-L1098, human) peptide - Powder PE-01AUQ90#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-01AUQ90#JAK3Selectide - JAK3 protein kinase substrate peptide - Powder PE-01BHS95#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-01BHS95#Janus protein-tyrosine kinase 3 (M782-L788, human) pY785 phosphopeptide - Powder PE-04AZR00#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-04AZR00
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S5
_
_
_
M
A
P
P
S
E
E
T
P
L
I
P
Site 2
T8
M
A
P
P
S
E
E
T
P
L
I
P
Q
R
S
Site 3
S15
T
P
L
I
P
Q
R
S
C
S
L
L
S
T
E
Site 4
S17
L
I
P
Q
R
S
C
S
L
L
S
T
E
A
G
Site 5
S20
Q
R
S
C
S
L
L
S
T
E
A
G
A
L
H
Site 6
T21
R
S
C
S
L
L
S
T
E
A
G
A
L
H
V
Site 7
S42
P
G
P
P
Q
R
L
S
F
S
F
G
D
H
L
Site 8
S44
P
P
Q
R
L
S
F
S
F
G
D
H
L
A
E
Site 9
S79
A
L
A
T
E
D
L
S
C
W
F
P
P
S
H
Site 10
S89
F
P
P
S
H
I
F
S
V
E
D
A
S
T
Q
Site 11
Y105
L
L
Y
R
I
R
F
Y
F
P
N
W
F
G
L
Site 12
S143
H
L
F
A
Q
H
R
S
D
L
V
S
G
R
L
Site 13
S147
Q
H
R
S
D
L
V
S
G
R
L
P
V
G
L
Site 14
S155
G
R
L
P
V
G
L
S
L
K
E
Q
G
E
C
Site 15
T187
R
P
G
E
L
L
K
T
V
S
Y
K
A
C
L
Site 16
Y190
E
L
L
K
T
V
S
Y
K
A
C
L
P
P
S
Site 17
S197
Y
K
A
C
L
P
P
S
L
R
D
L
I
Q
G
Site 18
S206
R
D
L
I
Q
G
L
S
F
V
T
R
R
R
I
Site 19
T216
T
R
R
R
I
R
R
T
V
R
R
A
L
R
R
Site 20
Y238
R
H
S
L
M
A
K
Y
I
M
D
L
E
R
L
Site 21
T319
A
G
E
H
R
L
V
T
V
T
R
T
D
N
Q
Site 22
T321
E
H
R
L
V
T
V
T
R
T
D
N
Q
I
L
Site 23
T353
D
G
Y
F
R
L
T
T
D
S
Q
H
F
F
C
Site 24
T391
F
A
I
N
K
L
K
T
G
G
S
R
P
G
S
Site 25
S394
N
K
L
K
T
G
G
S
R
P
G
S
Y
V
L
Site 26
S398
T
G
G
S
R
P
G
S
Y
V
L
R
R
S
P
Site 27
Y399
G
G
S
R
P
G
S
Y
V
L
R
R
S
P
Q
Site 28
S404
G
S
Y
V
L
R
R
S
P
Q
D
F
D
S
F
Site 29
Y425
Q
N
P
L
G
P
D
Y
K
G
C
L
I
R
R
Site 30
S448
V
G
L
S
R
P
H
S
S
L
R
E
L
L
A
Site 31
S449
G
L
S
R
P
H
S
S
L
R
E
L
L
A
T
Site 32
T472
D
G
V
A
V
T
L
T
S
C
C
I
P
R
P
Site 33
S473
G
V
A
V
T
L
T
S
C
C
I
P
R
P
K
Site 34
S483
I
P
R
P
K
E
K
S
N
L
I
V
V
Q
R
Site 35
S497
R
G
H
S
P
P
T
S
S
L
V
Q
P
Q
S
Site 36
S498
G
H
S
P
P
T
S
S
L
V
Q
P
Q
S
Q
Site 37
S504
S
S
L
V
Q
P
Q
S
Q
Y
Q
L
S
Q
M
Site 38
Y506
L
V
Q
P
Q
S
Q
Y
Q
L
S
Q
M
T
F
Site 39
T512
Q
Y
Q
L
S
Q
M
T
F
H
K
I
P
A
D
Site 40
S531
H
E
N
L
G
H
G
S
F
T
K
I
Y
R
G
Site 41
Y536
H
G
S
F
T
K
I
Y
R
G
C
R
H
E
V
Site 42
T551
V
D
G
E
A
R
K
T
E
V
L
L
K
V
M
Site 43
S568
K
H
K
N
C
M
E
S
F
L
E
A
A
S
L
Site 44
S577
L
E
A
A
S
L
M
S
Q
V
S
Y
R
H
L
Site 45
Y611
H
L
G
A
I
D
M
Y
L
R
K
R
G
H
L
Site 46
S622
R
G
H
L
V
P
A
S
W
K
L
Q
V
V
K
Site 47
Y637
Q
L
A
Y
A
L
N
Y
L
E
D
K
G
L
P
Site 48
S663
A
R
E
G
A
D
G
S
P
P
F
I
K
L
S
Site 49
S670
S
P
P
F
I
K
L
S
D
P
G
V
S
P
A
Site 50
T701
E
C
L
R
E
A
Q
T
L
S
L
E
A
D
K
Site 51
S703
L
R
E
A
Q
T
L
S
L
E
A
D
K
W
G
Site 52
S727
S
G
V
T
M
P
I
S
A
L
D
P
A
K
K
Site 53
Y738
P
A
K
K
L
Q
F
Y
E
D
R
Q
Q
L
P
Site 54
Y762
L
I
Q
Q
C
M
A
Y
E
P
V
Q
R
P
S
Site 55
S769
Y
E
P
V
Q
R
P
S
F
R
A
V
I
R
D
Site 56
S779
A
V
I
R
D
L
N
S
L
I
S
S
D
Y
E
Site 57
S782
R
D
L
N
S
L
I
S
S
D
Y
E
L
L
S
Site 58
S783
D
L
N
S
L
I
S
S
D
Y
E
L
L
S
D
Site 59
Y785
N
S
L
I
S
S
D
Y
E
L
L
S
D
P
T
Janus protein-tyrosine kinase 3 (M782-L788, human) pY785 phosphopeptide - Powder PE-04AZR00#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-04AZR00
Site 60
S789
S
S
D
Y
E
L
L
S
D
P
T
P
G
A
L
Site 61
T792
Y
E
L
L
S
D
P
T
P
G
A
L
A
P
R
Site 62
Y809
L
W
N
G
A
Q
L
Y
A
C
Q
D
P
T
I
Site 63
T815
L
Y
A
C
Q
D
P
T
I
F
E
E
R
H
L
Site 64
Y824
F
E
E
R
H
L
K
Y
I
S
Q
L
G
K
G
Site 65
S826
E
R
H
L
K
Y
I
S
Q
L
G
K
G
N
F
Site 66
S835
L
G
K
G
N
F
G
S
V
E
L
C
R
Y
D
Site 67
Y841
G
S
V
E
L
C
R
Y
D
P
L
G
D
N
T
Site 68
S860
A
V
K
Q
L
Q
H
S
G
P
D
Q
Q
R
D
Site 69
S880
Q
I
L
K
A
L
H
S
D
F
I
V
K
Y
R
Site 70
Y886
H
S
D
F
I
V
K
Y
R
G
V
S
Y
G
P
Site 71
S890
I
V
K
Y
R
G
V
S
Y
G
P
G
R
Q
S
Site 72
Y891
V
K
Y
R
G
V
S
Y
G
P
G
R
Q
S
L
Site 73
S897
S
Y
G
P
G
R
Q
S
L
R
L
V
M
E
Y
Site 74
Y904
S
L
R
L
V
M
E
Y
L
P
S
G
C
L
R
Site 75
S907
L
V
M
E
Y
L
P
S
G
C
L
R
D
F
L
Site 76
Y929
D
A
S
R
L
L
L
Y
S
S
Q
I
C
K
G
Site 77
S931
S
R
L
L
L
Y
S
S
Q
I
C
K
G
M
E
Site 78
Y939
Q
I
C
K
G
M
E
Y
L
G
S
R
R
C
V
Site 79
S942
K
G
M
E
Y
L
G
S
R
R
C
V
H
R
D
Site 80
Y980
L
L
P
L
D
K
D
Y
Y
V
V
R
E
P
G
Janus protein-tyrosine kinase 3 Y980+Y981 phosphosite-specific antibody AB-PK669#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-PK669
Site 81
Y981
L
P
L
D
K
D
Y
Y
V
V
R
E
P
G
Q
Janus protein-tyrosine kinase 3 Y980+Y981 phosphosite-specific antibody AB-PK669#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-PK669
Site 82
S989
V
V
R
E
P
G
Q
S
P
I
F
W
Y
A
P
Site 83
Y994
G
Q
S
P
I
F
W
Y
A
P
E
S
L
S
D
Site 84
S1000
W
Y
A
P
E
S
L
S
D
N
I
F
S
R
Q
Site 85
S1005
S
L
S
D
N
I
F
S
R
Q
S
D
V
W
S
Site 86
S1008
D
N
I
F
S
R
Q
S
D
V
W
S
F
G
V
Site 87
S1012
S
R
Q
S
D
V
W
S
F
G
V
V
L
Y
E
Site 88
S1027
L
F
T
Y
C
D
K
S
C
S
P
S
A
E
F
Site 89
S1029
T
Y
C
D
K
S
C
S
P
S
A
E
F
L
R
Site 90
S1031
C
D
K
S
C
S
P
S
A
E
F
L
R
M
M
Site 91
S1081
M
K
L
C
W
A
P
S
P
Q
D
R
P
S
F
Site 92
S1087
P
S
P
Q
D
R
P
S
F
S
A
L
G
P
Q
Site 93
S1100
P
Q
L
D
M
L
W
S
G
S
R
G
C
E
T
Site 94
S1102
L
D
M
L
W
S
G
S
R
G
C
E
T
H
A
Site 95
T1107
S
G
S
R
G
C
E
T
H
A
F
T
A
H
P
Site 96
T1111
G
C
E
T
H
A
F
T
A
H
P
E
G
K
H
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation