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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
STAT2
Full Name:
Signal transducer and activator of transcription 2
Alias:
p113
Type:
Transcription protein
Mass (Da):
97916
Number AA:
851
UniProt ID:
P52630
International Prot ID:
IPI00004312
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
GO:0005737
GO:0043226
Uniprot
OncoNet
Molecular Function:
GO:0003676
GO:0003677
GO:0003700
PhosphoSite+
KinaseNET
Biological Process:
GO:0006139
GO:0006350
GO:0006355
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S12
E
M
L
Q
N
L
D
S
P
F
Q
D
Q
L
H
Site 2
Y22
Q
D
Q
L
H
Q
L
Y
S
H
S
L
L
P
V
Site 3
S23
D
Q
L
H
Q
L
Y
S
H
S
L
L
P
V
D
Site 4
S25
L
H
Q
L
Y
S
H
S
L
L
P
V
D
I
R
Site 5
Y69
H
F
L
D
Q
L
N
Y
E
C
G
R
C
S
Q
Site 6
S75
N
Y
E
C
G
R
C
S
Q
D
P
E
S
L
L
Site 7
S80
R
C
S
Q
D
P
E
S
L
L
L
Q
H
N
L
Site 8
S98
C
R
D
I
Q
P
F
S
Q
D
P
T
Q
L
A
Site 9
T102
Q
P
F
S
Q
D
P
T
Q
L
A
E
M
I
F
Site 10
T136
Q
G
E
P
V
L
E
T
P
V
E
S
Q
Q
H
Site 11
S162
M
M
E
K
L
V
K
S
I
S
Q
L
K
D
Q
Site 12
S164
E
K
L
V
K
S
I
S
Q
L
K
D
Q
Q
D
Site 13
T185
K
I
Q
A
K
G
K
T
P
S
L
D
P
H
Q
Site 14
S187
Q
A
K
G
K
T
P
S
L
D
P
H
Q
T
K
Site 15
S217
R
K
E
V
L
D
A
S
K
A
L
L
G
R
L
Site 16
T260
H
G
L
E
Q
L
E
T
W
F
T
A
G
A
K
Site 17
S283
L
K
E
L
K
G
L
S
C
L
V
S
Y
Q
D
Site 18
S287
K
G
L
S
C
L
V
S
Y
Q
D
D
P
L
T
Site 19
Y288
G
L
S
C
L
V
S
Y
Q
D
D
P
L
T
K
Site 20
T294
S
Y
Q
D
D
P
L
T
K
G
V
D
L
R
N
Site 21
T327
T
Q
P
C
M
P
Q
T
P
H
R
P
L
I
L
Site 22
T336
H
R
P
L
I
L
K
T
G
S
K
F
T
V
R
Site 23
S356
R
L
Q
E
G
N
E
S
L
T
V
E
V
S
I
Site 24
T358
Q
E
G
N
E
S
L
T
V
E
V
S
I
D
R
Site 25
S362
E
S
L
T
V
E
V
S
I
D
R
N
P
P
Q
Site 26
T385
I
L
T
S
N
Q
K
T
L
T
P
E
K
G
Q
Site 27
T387
T
S
N
Q
K
T
L
T
P
E
K
G
Q
S
Q
Site 28
S393
L
T
P
E
K
G
Q
S
Q
G
L
I
W
D
F
Site 29
T404
I
W
D
F
G
Y
L
T
L
V
E
Q
R
S
G
Site 30
S410
L
T
L
V
E
Q
R
S
G
G
S
G
K
G
S
Site 31
S417
S
G
G
S
G
K
G
S
N
K
G
P
L
G
V
Site 32
Y437
I
I
S
F
T
V
K
Y
T
Y
Q
G
L
K
Q
Site 33
S476
V
L
W
F
N
L
L
S
P
N
L
Q
N
Q
Q
Site 34
S494
N
P
P
K
A
P
W
S
L
L
G
P
A
L
S
Site 35
S505
P
A
L
S
W
Q
F
S
S
Y
V
G
R
G
L
Site 36
S506
A
L
S
W
Q
F
S
S
Y
V
G
R
G
L
N
Site 37
Y507
L
S
W
Q
F
S
S
Y
V
G
R
G
L
N
S
Site 38
S514
Y
V
G
R
G
L
N
S
D
Q
L
S
M
L
R
Site 39
S518
G
L
N
S
D
Q
L
S
M
L
R
N
K
L
F
Site 40
T531
L
F
G
Q
N
C
R
T
E
D
P
L
L
S
W
Site 41
S537
R
T
E
D
P
L
L
S
W
A
D
F
T
K
R
Site 42
T542
L
L
S
W
A
D
F
T
K
R
E
S
P
P
G
Site 43
S546
A
D
F
T
K
R
E
S
P
P
G
K
L
P
F
Site 44
S584
I
M
G
F
V
S
R
S
Q
E
R
R
L
L
K
Site 45
T593
E
R
R
L
L
K
K
T
M
S
G
T
F
L
L
Site 46
S595
R
L
L
K
K
T
M
S
G
T
F
L
L
R
F
Site 47
T597
L
K
K
T
M
S
G
T
F
L
L
R
F
S
E
Site 48
S603
G
T
F
L
L
R
F
S
E
S
S
E
G
G
I
Site 49
S606
L
L
R
F
S
E
S
S
E
G
G
I
T
C
S
Site 50
T611
E
S
S
E
G
G
I
T
C
S
W
V
E
H
Q
Site 51
S613
S
E
G
G
I
T
C
S
W
V
E
H
Q
D
D
Site 52
S627
D
D
K
V
L
I
Y
S
V
Q
P
Y
T
K
E
Site 53
Y631
L
I
Y
S
V
Q
P
Y
T
K
E
V
L
Q
S
Site 54
T632
I
Y
S
V
Q
P
Y
T
K
E
V
L
Q
S
L
Site 55
Y648
L
T
E
I
I
R
H
Y
Q
L
L
T
E
E
N
Site 56
T652
I
R
H
Y
Q
L
L
T
E
E
N
I
P
E
N
Site 57
Y665
E
N
P
L
R
F
L
Y
P
R
I
P
R
D
E
Site 58
Y677
R
D
E
A
F
G
C
Y
Y
Q
E
K
V
N
L
Site 59
Y678
D
E
A
F
G
C
Y
Y
Q
E
K
V
N
L
Q
Site 60
Y690
N
L
Q
E
R
R
K
Y
L
K
H
R
L
I
V
Site 61
S699
K
H
R
L
I
V
V
S
N
R
Q
V
D
E
L
Site 62
S720
K
P
E
P
E
L
E
S
L
E
L
E
L
G
L
Site 63
S753
D
L
G
P
E
L
E
S
V
L
E
S
T
L
E
Site 64
T758
L
E
S
V
L
E
S
T
L
E
P
V
I
E
P
Site 65
S771
E
P
T
L
C
M
V
S
Q
T
V
P
E
P
D
Site 66
T773
T
L
C
M
V
S
Q
T
V
P
E
P
D
Q
G
Site 67
S783
E
P
D
Q
G
P
V
S
Q
P
V
P
E
P
D
Site 68
T800
C
D
L
R
H
L
N
T
E
P
M
E
I
F
R
Site 69
Y833
Q
N
T
V
D
E
V
Y
V
S
R
P
S
H
F
Site 70
S835
T
V
D
E
V
Y
V
S
R
P
S
H
F
Y
T
Site 71
S838
E
V
Y
V
S
R
P
S
H
F
Y
T
D
G
P
Site 72
Y841
V
S
R
P
S
H
F
Y
T
D
G
P
L
M
P
Site 73
T842
S
R
P
S
H
F
Y
T
D
G
P
L
M
P
S
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation