KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
MSH6
Full Name:
DNA mismatch repair protein Msh6
Alias:
DNA mismatch repair MSH6; G/T mismatch binding protein; GTBP; GTMBP; MutS 6; MutS homolog 6 (E. coli); MutS-alpha 160 kDa; MutS-alpha 160 kDa subunit; P160
Type:
DNA binding protein
Mass (Da):
152786
Number AA:
1360
UniProt ID:
P52701
International Prot ID:
IPI00384456
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0032301
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0005515
GO:0000701
PhosphoSite+
KinaseNET
Biological Process:
GO:0008630
GO:0008340
GO:0045190
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T6
_
_
M
S
R
Q
S
T
L
Y
S
F
F
P
K
Site 2
Y8
M
S
R
Q
S
T
L
Y
S
F
F
P
K
S
P
Site 3
S9
S
R
Q
S
T
L
Y
S
F
F
P
K
S
P
A
Site 4
S14
L
Y
S
F
F
P
K
S
P
A
L
S
D
A
N
Site 5
S18
F
P
K
S
P
A
L
S
D
A
N
K
A
S
A
Site 6
S24
L
S
D
A
N
K
A
S
A
R
A
S
R
E
G
Site 7
S28
N
K
A
S
A
R
A
S
R
E
G
G
R
A
A
Site 8
S41
A
A
A
A
P
G
A
S
P
S
P
G
G
D
A
Site 9
S43
A
A
P
G
A
S
P
S
P
G
G
D
A
A
W
Site 10
S51
P
G
G
D
A
A
W
S
E
A
G
P
G
P
R
Site 11
S63
G
P
R
P
L
A
R
S
A
S
P
P
K
A
K
Site 12
S65
R
P
L
A
R
S
A
S
P
P
K
A
K
N
L
Site 13
S79
L
N
G
G
L
R
R
S
V
A
P
A
A
P
T
Site 14
T86
S
V
A
P
A
A
P
T
S
C
D
F
S
P
G
Site 15
S87
V
A
P
A
A
P
T
S
C
D
F
S
P
G
D
Site 16
S91
A
P
T
S
C
D
F
S
P
G
D
L
V
W
A
Site 17
T118
Y
N
H
P
F
D
G
T
F
I
R
E
K
G
K
Site 18
S126
F
I
R
E
K
G
K
S
V
R
V
H
V
Q
F
Site 19
S137
H
V
Q
F
F
D
D
S
P
T
R
G
W
V
S
Site 20
T139
Q
F
F
D
D
S
P
T
R
G
W
V
S
K
R
Site 21
S144
S
P
T
R
G
W
V
S
K
R
L
L
K
P
Y
Site 22
Y151
S
K
R
L
L
K
P
Y
T
G
S
K
S
K
E
Site 23
T152
K
R
L
L
K
P
Y
T
G
S
K
S
K
E
A
Site 24
S156
K
P
Y
T
G
S
K
S
K
E
A
Q
K
G
G
Site 25
S167
Q
K
G
G
H
F
Y
S
A
K
P
E
I
L
R
Site 26
S200
L
A
V
C
D
E
P
S
E
P
E
E
E
E
E
Site 27
T213
E
E
M
E
V
G
T
T
Y
V
T
D
K
S
E
Site 28
Y214
E
M
E
V
G
T
T
Y
V
T
D
K
S
E
E
Site 29
S219
T
T
Y
V
T
D
K
S
E
E
D
N
E
I
E
Site 30
S227
E
E
D
N
E
I
E
S
E
E
E
V
Q
P
K
Site 31
T235
E
E
E
V
Q
P
K
T
Q
G
S
R
R
S
S
Site 32
S238
V
Q
P
K
T
Q
G
S
R
R
S
S
R
Q
I
Site 33
S241
K
T
Q
G
S
R
R
S
S
R
Q
I
K
K
R
Site 34
S242
T
Q
G
S
R
R
S
S
R
Q
I
K
K
R
R
Site 35
S252
I
K
K
R
R
V
I
S
D
S
E
S
D
I
G
Site 36
S254
K
R
R
V
I
S
D
S
E
S
D
I
G
G
S
Site 37
S256
R
V
I
S
D
S
E
S
D
I
G
G
S
D
V
Site 38
S261
S
E
S
D
I
G
G
S
D
V
E
F
K
P
D
Site 39
T269
D
V
E
F
K
P
D
T
K
E
E
G
S
S
D
Site 40
S274
P
D
T
K
E
E
G
S
S
D
E
I
S
S
G
Site 41
S275
D
T
K
E
E
G
S
S
D
E
I
S
S
G
V
Site 42
S279
E
G
S
S
D
E
I
S
S
G
V
G
D
S
E
Site 43
S280
G
S
S
D
E
I
S
S
G
V
G
D
S
E
S
Site 44
S285
I
S
S
G
V
G
D
S
E
S
E
G
L
N
S
Site 45
S287
S
G
V
G
D
S
E
S
E
G
L
N
S
P
V
Site 46
S292
S
E
S
E
G
L
N
S
P
V
K
V
A
R
K
Site 47
T305
R
K
R
K
R
M
V
T
G
N
G
S
L
K
R
Site 48
S309
R
M
V
T
G
N
G
S
L
K
R
K
S
S
R
Site 49
S314
N
G
S
L
K
R
K
S
S
R
K
E
T
P
S
Site 50
S315
G
S
L
K
R
K
S
S
R
K
E
T
P
S
A
Site 51
T319
R
K
S
S
R
K
E
T
P
S
A
T
K
Q
A
Site 52
S321
S
S
R
K
E
T
P
S
A
T
K
Q
A
T
S
Site 53
S328
S
A
T
K
Q
A
T
S
I
S
S
E
T
K
N
Site 54
T336
I
S
S
E
T
K
N
T
L
R
A
F
S
A
P
Site 55
S341
K
N
T
L
R
A
F
S
A
P
Q
N
S
E
S
Site 56
S346
A
F
S
A
P
Q
N
S
E
S
Q
A
H
V
S
Site 57
S348
S
A
P
Q
N
S
E
S
Q
A
H
V
S
G
G
Site 58
S353
S
E
S
Q
A
H
V
S
G
G
G
D
D
S
S
Site 59
S359
V
S
G
G
G
D
D
S
S
R
P
T
V
W
Y
Site 60
S360
S
G
G
G
D
D
S
S
R
P
T
V
W
Y
H
Site 61
T363
G
D
D
S
S
R
P
T
V
W
Y
H
E
T
L
Site 62
Y366
S
S
R
P
T
V
W
Y
H
E
T
L
E
W
L
Site 63
S394
D
H
P
D
F
D
A
S
T
L
Y
V
P
E
D
Site 64
T395
H
P
D
F
D
A
S
T
L
Y
V
P
E
D
F
Site 65
Y397
D
F
D
A
S
T
L
Y
V
P
E
D
F
L
N
Site 66
S470
E
I
A
F
G
R
Y
S
D
S
L
V
Q
K
G
Site 67
S472
A
F
G
R
Y
S
D
S
L
V
Q
K
G
Y
K
Site 68
T488
A
R
V
E
Q
T
E
T
P
E
M
M
E
A
R
Site 69
Y505
K
M
A
H
I
S
K
Y
D
R
V
V
R
R
E
Site 70
T518
R
E
I
C
R
I
I
T
K
G
T
Q
T
Y
S
Site 71
S525
T
K
G
T
Q
T
Y
S
V
L
E
G
D
P
S
Site 72
S532
S
V
L
E
G
D
P
S
E
N
Y
S
K
Y
L
Site 73
Y535
E
G
D
P
S
E
N
Y
S
K
Y
L
L
S
L
Site 74
S536
G
D
P
S
E
N
Y
S
K
Y
L
L
S
L
K
Site 75
Y538
P
S
E
N
Y
S
K
Y
L
L
S
L
K
E
K
Site 76
S541
N
Y
S
K
Y
L
L
S
L
K
E
K
E
E
D
Site 77
S549
L
K
E
K
E
E
D
S
S
G
H
T
R
A
Y
Site 78
S550
K
E
K
E
E
D
S
S
G
H
T
R
A
Y
G
Site 79
T553
E
E
D
S
S
G
H
T
R
A
Y
G
V
C
F
Site 80
Y556
S
S
G
H
T
R
A
Y
G
V
C
F
V
D
T
Site 81
S580
F
S
D
D
R
H
C
S
R
F
R
T
L
V
A
Site 82
T584
R
H
C
S
R
F
R
T
L
V
A
H
Y
P
P
Site 83
S602
L
F
E
K
G
N
L
S
K
E
T
K
T
I
L
Site 84
T607
N
L
S
K
E
T
K
T
I
L
K
S
S
L
S
Site 85
S611
E
T
K
T
I
L
K
S
S
L
S
C
S
L
Q
Site 86
S612
T
K
T
I
L
K
S
S
L
S
C
S
L
Q
E
Site 87
S625
Q
E
G
L
I
P
G
S
Q
F
W
D
A
S
K
Site 88
S631
G
S
Q
F
W
D
A
S
K
T
L
R
T
L
L
Site 89
T633
Q
F
W
D
A
S
K
T
L
R
T
L
L
E
E
Site 90
Y642
R
T
L
L
E
E
E
Y
F
R
E
K
L
S
D
Site 91
S648
E
Y
F
R
E
K
L
S
D
G
I
G
V
M
L
Site 92
S664
Q
V
L
K
G
M
T
S
E
S
D
S
I
G
L
Site 93
S666
L
K
G
M
T
S
E
S
D
S
I
G
L
T
P
Site 94
S668
G
M
T
S
E
S
D
S
I
G
L
T
P
G
E
Site 95
T672
E
S
D
S
I
G
L
T
P
G
E
K
S
E
L
Site 96
S702
L
I
D
Q
E
L
L
S
M
A
N
F
E
E
Y
Site 97
Y709
S
M
A
N
F
E
E
Y
I
P
L
D
S
D
T
Site 98
S714
E
E
Y
I
P
L
D
S
D
T
V
S
T
T
R
Site 99
T716
Y
I
P
L
D
S
D
T
V
S
T
T
R
S
G
Site 100
S718
P
L
D
S
D
T
V
S
T
T
R
S
G
A
I
Site 101
S722
D
T
V
S
T
T
R
S
G
A
I
F
T
K
A
Site 102
S753
F
L
N
G
T
N
G
S
T
E
G
T
L
L
E
Site 103
T757
T
N
G
S
T
E
G
T
L
L
E
R
V
D
T
Site 104
T764
T
L
L
E
R
V
D
T
C
H
T
P
F
G
K
Site 105
T767
E
R
V
D
T
C
H
T
P
F
G
K
R
L
L
Site 106
S823
P
D
L
E
R
L
L
S
K
I
H
N
V
G
S
Site 107
S830
S
K
I
H
N
V
G
S
P
L
K
S
Q
N
H
Site 108
S834
N
V
G
S
P
L
K
S
Q
N
H
P
D
S
R
Site 109
S840
K
S
Q
N
H
P
D
S
R
A
I
M
Y
E
E
Site 110
Y845
P
D
S
R
A
I
M
Y
E
E
T
T
Y
S
K
Site 111
Y850
I
M
Y
E
E
T
T
Y
S
K
K
K
I
I
D
Site 112
S892
K
I
L
K
Q
V
I
S
L
Q
T
K
N
P
E
Site 113
T895
K
Q
V
I
S
L
Q
T
K
N
P
E
G
R
F
Site 114
T906
E
G
R
F
P
D
L
T
V
E
L
N
R
W
D
Site 115
T914
V
E
L
N
R
W
D
T
A
F
D
H
E
K
A
Site 116
T924
D
H
E
K
A
R
K
T
G
L
I
T
P
K
A
Site 117
T928
A
R
K
T
G
L
I
T
P
K
A
G
F
D
S
Site 118
S935
T
P
K
A
G
F
D
S
D
Y
D
Q
A
L
A
Site 119
Y937
K
A
G
F
D
S
D
Y
D
Q
A
L
A
D
I
Site 120
S950
D
I
R
E
N
E
Q
S
L
L
E
Y
L
E
K
Site 121
Y954
N
E
Q
S
L
L
E
Y
L
E
K
Q
R
N
R
Site 122
Y969
I
G
C
R
T
I
V
Y
W
G
I
G
R
N
R
Site 123
Y977
W
G
I
G
R
N
R
Y
Q
L
E
I
P
E
N
Site 124
T987
E
I
P
E
N
F
T
T
R
N
L
P
E
E
Y
Site 125
Y994
T
R
N
L
P
E
E
Y
E
L
K
S
T
K
K
Site 126
S998
P
E
E
Y
E
L
K
S
T
K
K
G
C
K
R
Site 127
T999
E
E
Y
E
L
K
S
T
K
K
G
C
K
R
Y
Site 128
T1008
K
G
C
K
R
Y
W
T
K
T
I
E
K
K
L
Site 129
T1010
C
K
R
Y
W
T
K
T
I
E
K
K
L
A
N
Site 130
S1028
A
E
E
R
R
D
V
S
L
K
D
C
M
R
R
Site 131
Y1038
D
C
M
R
R
L
F
Y
N
F
D
K
N
Y
K
Site 132
Y1044
F
Y
N
F
D
K
N
Y
K
D
W
Q
S
A
V
Site 133
S1067
L
L
C
L
A
N
Y
S
R
G
G
D
G
P
M
Site 134
T1085
V
I
L
L
P
E
D
T
P
P
F
L
E
L
K
Site 135
S1094
P
F
L
E
L
K
G
S
R
H
P
C
I
T
K
Site 136
T1100
G
S
R
H
P
C
I
T
K
T
F
F
G
D
D
Site 137
Y1128
E
Q
E
N
G
K
A
Y
C
V
L
V
T
G
P
Site 138
S1141
G
P
N
M
G
G
K
S
T
L
M
R
Q
A
G
Site 139
T1142
P
N
M
G
G
K
S
T
L
M
R
Q
A
G
L
Site 140
T1175
T
P
I
D
R
V
F
T
R
L
G
A
S
D
R
Site 141
S1180
V
F
T
R
L
G
A
S
D
R
I
M
S
G
E
Site 142
S1185
G
A
S
D
R
I
M
S
G
E
S
T
F
F
V
Site 143
T1189
R
I
M
S
G
E
S
T
F
F
V
E
L
S
E
Site 144
T1219
V
D
E
L
G
R
G
T
A
T
F
D
G
T
A
Site 145
T1247
K
C
R
T
L
F
S
T
H
Y
H
S
L
V
E
Site 146
Y1249
R
T
L
F
S
T
H
Y
H
S
L
V
E
D
Y
Site 147
S1251
L
F
S
T
H
Y
H
S
L
V
E
D
Y
S
Q
Site 148
Y1256
Y
H
S
L
V
E
D
Y
S
Q
N
V
A
V
R
Site 149
S1257
H
S
L
V
E
D
Y
S
Q
N
V
A
V
R
L
Site 150
S1279
E
N
E
C
E
D
P
S
Q
E
T
I
T
F
L
Site 151
T1284
D
P
S
Q
E
T
I
T
F
L
Y
K
F
I
K
Site 152
S1297
I
K
G
A
C
P
K
S
Y
G
F
N
A
A
R
Site 153
S1329
E
F
E
K
M
N
Q
S
L
R
L
F
R
E
V
Site 154
S1340
F
R
E
V
C
L
A
S
E
R
S
T
V
D
A
Site 155
T1344
C
L
A
S
E
R
S
T
V
D
A
E
A
V
H
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation