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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
VAV2
Full Name:
Guanine nucleotide exchange factor VAV2
Alias:
Vav 2 guanine nucleotide exchange factor; Vav-2
Type:
Guanine nucleotide exchange factor for G protein
Mass (Da):
101289
Number AA:
878
UniProt ID:
P52735
International Prot ID:
IPI00642324
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005829
Uniprot
OncoNet
Molecular Function:
GO:0005089
GO:0008270
PhosphoSite+
KinaseNET
Biological Process:
GO:0006915
GO:0008624
GO:0035023
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S51
C
Q
L
L
H
N
L
S
P
G
S
I
D
L
K
Site 2
S54
L
H
N
L
S
P
G
S
I
D
L
K
D
I
N
Site 3
S91
D
K
F
G
L
R
N
S
E
L
F
D
P
F
D
Site 4
S119
V
S
R
L
S
L
H
S
I
A
Q
N
K
G
I
Site 5
S131
K
G
I
R
P
F
P
S
E
E
T
T
E
N
D
Site 6
T135
P
F
P
S
E
E
T
T
E
N
D
D
D
V
Y
Site 7
Y142
T
E
N
D
D
D
V
Y
R
S
L
E
E
L
A
Site 8
S144
N
D
D
D
V
Y
R
S
L
E
E
L
A
D
E
Site 9
Y159
H
D
L
G
E
D
I
Y
D
C
V
P
C
E
D
Site 10
Y172
E
D
G
G
D
D
I
Y
E
D
I
I
K
V
E
Site 11
T209
C
L
L
E
I
Q
E
T
E
A
K
Y
Y
R
T
Site 12
Y213
I
Q
E
T
E
A
K
Y
Y
R
T
L
E
D
I
Site 13
Y214
Q
E
T
E
A
K
Y
Y
R
T
L
E
D
I
E
Site 14
Y224
L
E
D
I
E
K
N
Y
M
S
P
L
R
L
V
Site 15
S226
D
I
E
K
N
Y
M
S
P
L
R
L
V
L
S
Site 16
Y283
F
K
E
R
L
L
I
Y
G
E
Y
C
S
H
M
Site 17
Y286
R
L
L
I
Y
G
E
Y
C
S
H
M
E
H
A
Site 18
S348
L
L
L
K
E
L
L
S
H
S
A
E
R
P
E
Site 19
S350
L
K
E
L
L
S
H
S
A
E
R
P
E
R
Q
Site 20
T382
E
V
K
R
D
K
E
T
L
R
K
I
S
E
F
Site 21
S387
K
E
T
L
R
K
I
S
E
F
Q
S
S
I
E
Site 22
S391
R
K
I
S
E
F
Q
S
S
I
E
N
L
Q
V
Site 23
S392
K
I
S
E
F
Q
S
S
I
E
N
L
Q
V
K
Site 24
Y426
N
H
T
K
Q
D
R
Y
L
F
L
F
D
K
V
Site 25
Y444
C
K
R
K
G
Y
S
Y
E
L
K
E
I
I
E
Site 26
T458
E
L
L
F
H
K
M
T
D
D
P
M
N
N
K
Site 27
Y477
S
H
G
K
M
W
S
Y
G
F
Y
L
I
H
L
Site 28
Y480
K
M
W
S
Y
G
F
Y
L
I
H
L
Q
G
K
Site 29
S512
E
Q
F
E
M
A
M
S
N
I
K
P
D
K
A
Site 30
Y549
M
F
L
R
G
T
F
Y
Q
G
Y
M
C
T
K
Site 31
Y552
R
G
T
F
Y
Q
G
Y
M
C
T
K
C
G
V
Site 32
T575
V
I
P
P
C
K
F
T
S
P
A
D
L
D
A
Site 33
S576
I
P
P
C
K
F
T
S
P
A
D
L
D
A
S
Site 34
S583
S
P
A
D
L
D
A
S
G
A
G
P
G
P
K
Site 35
S626
L
L
R
G
D
P
E
S
P
W
W
E
G
R
L
Site 36
S639
R
L
V
Q
T
R
K
S
G
Y
F
P
S
S
S
Site 37
Y641
V
Q
T
R
K
S
G
Y
F
P
S
S
S
V
K
Site 38
S644
R
K
S
G
Y
F
P
S
S
S
V
K
P
C
P
Site 39
S645
K
S
G
Y
F
P
S
S
S
V
K
P
C
P
V
Site 40
S646
S
G
Y
F
P
S
S
S
V
K
P
C
P
V
D
Site 41
S659
V
D
G
R
P
P
I
S
R
P
P
S
R
E
I
Site 42
S663
P
P
I
S
R
P
P
S
R
E
I
D
Y
T
A
Site 43
Y668
P
P
S
R
E
I
D
Y
T
A
Y
P
W
F
A
Site 44
T669
P
S
R
E
I
D
Y
T
A
Y
P
W
F
A
G
Site 45
Y671
R
E
I
D
Y
T
A
Y
P
W
F
A
G
N
M
Site 46
T683
G
N
M
E
R
Q
Q
T
D
N
L
L
K
S
H
Site 47
S689
Q
T
D
N
L
L
K
S
H
A
S
G
T
Y
L
Site 48
S739
T
E
A
K
K
F
D
S
L
L
E
L
V
E
Y
Site 49
Y746
S
L
L
E
L
V
E
Y
Y
Q
C
H
S
L
K
Site 50
Y747
L
L
E
L
V
E
Y
Y
Q
C
H
S
L
K
E
Site 51
S755
Q
C
H
S
L
K
E
S
F
K
Q
L
D
T
T
Site 52
T761
E
S
F
K
Q
L
D
T
T
L
K
Y
P
Y
K
Site 53
T762
S
F
K
Q
L
D
T
T
L
K
Y
P
Y
K
S
Site 54
Y765
Q
L
D
T
T
L
K
Y
P
Y
K
S
R
E
R
Site 55
S769
R
S
A
S
R
A
S
S
R
S
P
V
F
T
P
Site 56
S773
P
Y
K
S
R
E
R
S
A
S
R
A
S
S
R
Site 57
S775
K
S
R
E
R
S
A
S
R
A
S
S
R
S
P
Site 58
S778
E
R
S
A
S
R
A
S
S
R
S
P
A
S
C
Site 59
S779
R
S
A
S
R
A
S
S
R
S
P
A
S
C
A
Site 60
S781
A
S
R
A
S
S
R
S
P
A
S
C
A
S
Y
Site 61
S784
A
S
S
R
S
P
A
S
C
A
S
Y
N
F
S
Site 62
S787
R
S
P
A
S
C
A
S
Y
N
F
S
F
L
S
Site 63
Y788
S
P
A
S
C
A
S
Y
N
F
S
F
L
S
P
Site 64
S799
F
L
S
P
Q
G
L
S
F
A
S
Q
G
P
S
Site 65
S802
P
Q
G
L
S
F
A
S
Q
G
P
S
A
P
F
Site 66
S836
A
R
D
M
R
E
L
S
L
R
E
G
D
V
V
Site 67
Y846
E
G
D
V
V
R
I
Y
S
R
I
G
G
D
Q
Site 68
S847
G
D
V
V
R
I
Y
S
R
I
G
G
D
Q
G
Site 69
S869
G
R
I
G
W
F
P
S
T
Y
V
E
E
E
G
Site 70
T870
R
I
G
W
F
P
S
T
Y
V
E
E
E
G
I
Site 71
Y871
I
G
W
F
P
S
T
Y
V
E
E
E
G
I
Q
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation