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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
SMS
Full Name:
Spermine synthase
Alias:
MRSR; Spermidine aminopropyltransferase; SPMSY; SpS; SPSY; SRS
Type:
Amino Acid Metabolism - cysteine and methionine; Other Amino Acids Metabolism - glutathione; Other Amino Acids Metabolism - beta-alanine; EC 2.5.1.22; Amino Acid Metabolism - arginine and proline; Transferase
Mass (Da):
41268
Number AA:
366
UniProt ID:
P52788
International Prot ID:
IPI00005102
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005829
Uniprot
OncoNet
Molecular Function:
GO:0004766
GO:0016768
PhosphoSite+
KinaseNET
Biological Process:
GO:0006555
GO:0006597
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T21
G
A
K
A
D
G
E
T
I
L
K
G
L
Q
S
Site 2
S28
T
I
L
K
G
L
Q
S
I
F
Q
E
Q
G
M
Site 3
Y47
H
T
W
Q
D
H
G
Y
L
A
T
Y
T
N
K
Site 4
Y51
D
H
G
Y
L
A
T
Y
T
N
K
N
G
S
F
Site 5
T52
H
G
Y
L
A
T
Y
T
N
K
N
G
S
F
A
Site 6
S57
T
Y
T
N
K
N
G
S
F
A
N
L
R
I
Y
Site 7
S75
L
V
L
L
D
L
Q
S
Y
D
G
D
A
Q
G
Site 8
Y76
V
L
L
D
L
Q
S
Y
D
G
D
A
Q
G
K
Site 9
S88
Q
G
K
E
E
I
D
S
I
L
N
K
V
E
E
Site 10
S101
E
E
R
M
K
E
L
S
Q
D
S
T
G
R
V
Site 11
S104
M
K
E
L
S
Q
D
S
T
G
R
V
K
R
L
Site 12
T105
K
E
L
S
Q
D
S
T
G
R
V
K
R
L
P
Site 13
Y123
R
G
G
A
I
D
R
Y
W
P
T
A
D
G
R
Site 14
Y134
A
D
G
R
L
V
E
Y
D
I
D
E
V
V
Y
Site 15
Y141
Y
D
I
D
E
V
V
Y
D
E
D
S
P
Y
Q
Site 16
S145
E
V
V
Y
D
E
D
S
P
Y
Q
N
I
K
I
Site 17
Y147
V
Y
D
E
D
S
P
Y
Q
N
I
K
I
L
H
Site 18
S184
Y
T
R
A
I
M
G
S
G
K
E
D
Y
T
G
Site 19
Y189
M
G
S
G
K
E
D
Y
T
G
K
D
V
L
I
Site 20
T190
G
S
G
K
E
D
Y
T
G
K
D
V
L
I
L
Site 21
Y232
V
I
D
G
C
K
K
Y
M
R
K
T
C
G
D
Site 22
T236
C
K
K
Y
M
R
K
T
C
G
D
V
L
D
N
Site 23
Y249
D
N
L
K
G
D
C
Y
Q
V
L
I
E
D
C
Site 24
Y272
K
E
G
R
E
F
D
Y
V
I
N
D
L
T
A
Site 25
S283
D
L
T
A
V
P
I
S
T
S
P
E
E
D
S
Site 26
S285
T
A
V
P
I
S
T
S
P
E
E
D
S
T
W
Site 27
S290
S
T
S
P
E
E
D
S
T
W
E
F
L
R
L
Site 28
T291
T
S
P
E
E
D
S
T
W
E
F
L
R
L
I
Site 29
Y312
V
L
K
Q
D
G
K
Y
F
T
Q
G
N
C
V
Site 30
T322
Q
G
N
C
V
N
L
T
E
A
L
S
L
Y
E
Site 31
S326
V
N
L
T
E
A
L
S
L
Y
E
E
Q
L
G
Site 32
Y328
L
T
E
A
L
S
L
Y
E
E
Q
L
G
R
L
Site 33
Y336
E
E
Q
L
G
R
L
Y
C
P
V
E
F
S
K
Site 34
T359
L
E
L
W
V
F
Y
T
V
W
K
K
A
K
P
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation