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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
HK2
Full Name:
Hexokinase-2
Alias:
Brain form hexokinase; EC 2.7.1.1; Glycolytic enzyme; HK1-ta; HK1-tb; HKI; HXK1; Muscle form hexokinase
Type:
Enzyme, metabolite kinase, glucose
Mass (Da):
102380
Number AA:
917
UniProt ID:
P52789
International Prot ID:
IPI00102864
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005829
GO:0005741
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0004396
PhosphoSite+
KinaseNET
Biological Process:
GO:0006096
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y25
Q
V
Q
K
V
D
Q
Y
L
Y
H
M
R
L
S
Site 2
Y27
Q
K
V
D
Q
Y
L
Y
H
M
R
L
S
D
E
Site 3
S32
Y
L
Y
H
M
R
L
S
D
E
T
L
L
E
I
Site 4
T35
H
M
R
L
S
D
E
T
L
L
E
I
S
K
R
Site 5
S40
D
E
T
L
L
E
I
S
K
R
F
R
K
E
M
Site 6
S70
M
L
P
T
F
V
R
S
T
P
D
G
T
E
H
Site 7
T71
L
P
T
F
V
R
S
T
P
D
G
T
E
H
G
Site 8
Y112
V
E
M
E
N
Q
I
Y
A
I
P
E
D
I
M
Site 9
S122
P
E
D
I
M
R
G
S
G
T
Q
L
F
D
H
Site 10
T153
K
K
L
P
L
G
F
T
F
S
F
P
C
H
Q
Site 11
S166
H
Q
T
K
L
D
E
S
F
L
V
S
W
T
K
Site 12
S170
L
D
E
S
F
L
V
S
W
T
K
G
F
K
S
Site 13
S177
S
W
T
K
G
F
K
S
S
G
V
E
G
R
D
Site 14
Y238
G
T
G
S
N
A
C
Y
M
E
E
M
R
H
I
Site 15
S269
G
A
F
G
D
D
G
S
L
N
D
I
R
T
E
Site 16
T275
G
S
L
N
D
I
R
T
E
F
D
Q
E
I
D
Site 17
S285
D
Q
E
I
D
M
G
S
L
N
P
G
K
Q
L
Site 18
Y301
E
K
M
I
S
G
M
Y
M
G
E
L
V
R
L
Site 19
T331
L
S
P
E
L
L
N
T
G
R
F
E
T
K
D
Site 20
T336
L
N
T
G
R
F
E
T
K
D
I
S
D
I
E
Site 21
S340
R
F
E
T
K
D
I
S
D
I
E
G
E
K
D
Site 22
T364
M
R
L
G
L
D
P
T
Q
E
D
C
V
A
T
Site 23
S408
K
G
E
E
R
L
R
S
T
I
G
V
D
G
S
Site 24
T409
G
E
E
R
L
R
S
T
I
G
V
D
G
S
V
Site 25
S415
S
T
I
G
V
D
G
S
V
Y
K
K
H
P
H
Site 26
Y417
I
G
V
D
G
S
V
Y
K
K
H
P
H
F
A
Site 27
T430
F
A
K
R
L
H
K
T
V
R
R
L
V
P
G
Site 28
S445
C
D
V
R
F
L
R
S
E
D
G
S
G
K
G
Site 29
S449
F
L
R
S
E
D
G
S
G
K
G
A
A
M
V
Site 30
Y461
A
M
V
T
A
V
A
Y
R
L
A
D
Q
H
R
Site 31
T473
Q
H
R
A
R
Q
K
T
L
E
H
L
Q
L
S
Site 32
S480
T
L
E
H
L
Q
L
S
H
D
Q
L
L
E
V
Site 33
S500
V
E
M
E
R
G
L
S
K
E
T
H
A
S
A
Site 34
S506
L
S
K
E
T
H
A
S
A
P
V
K
M
L
P
Site 35
T519
L
P
T
Y
V
C
A
T
P
D
G
T
E
K
G
Site 36
Y560
V
E
M
H
N
K
I
Y
A
I
P
Q
E
V
M
Site 37
S603
L
P
L
G
F
T
F
S
F
P
C
Q
Q
N
S
Site 38
S610
S
F
P
C
Q
Q
N
S
L
D
E
S
I
L
L
Site 39
S614
Q
Q
N
S
L
D
E
S
I
L
L
K
W
T
K
Site 40
Y686
G
T
G
S
N
A
C
Y
M
E
E
M
R
N
V
Site 41
T723
G
C
L
D
D
F
R
T
E
F
D
V
A
V
D
Site 42
S733
D
V
A
V
D
E
L
S
L
N
P
G
K
Q
R
Site 43
S746
Q
R
F
E
K
M
I
S
G
M
Y
L
G
E
I
Site 44
Y749
E
K
M
I
S
G
M
Y
L
G
E
I
V
R
N
Site 45
T762
R
N
I
L
I
D
F
T
K
R
G
L
L
F
R
Site 46
S773
L
L
F
R
G
R
I
S
E
R
L
K
T
R
G
Site 47
T778
R
I
S
E
R
L
K
T
R
G
I
F
E
T
K
Site 48
T784
K
T
R
G
I
F
E
T
K
F
L
S
Q
I
E
Site 49
S889
L
A
P
K
C
D
V
S
F
L
Q
S
E
D
G
Site 50
S893
C
D
V
S
F
L
Q
S
E
D
G
S
G
K
G
Site 51
S897
F
L
Q
S
E
D
G
S
G
K
G
A
A
L
I
Site 52
T905
G
K
G
A
A
L
I
T
A
V
A
C
R
I
R
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation