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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
NDST2
Full Name:
Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 2
Alias:
Glucosaminyl N-deacetylase/N-sulfotransferase 2;N-heparan sulfate sulfotransferase 2
Type:
Mass (Da):
100875
Number AA:
883
UniProt ID:
P52849
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y36
G
S
M
G
F
L
A
Y
Y
V
S
T
S
P
K
Site 2
S39
G
F
L
A
Y
Y
V
S
T
S
P
K
A
K
E
Site 3
S41
L
A
Y
Y
V
S
T
S
P
K
A
K
E
P
L
Site 4
T80
R
P
P
R
P
P
E
T
A
R
T
E
P
V
V
Site 5
T83
R
P
P
E
T
A
R
T
E
P
V
V
L
V
F
Site 6
S108
E
I
V
A
I
L
E
S
S
R
F
R
Y
S
T
Site 7
S109
I
V
A
I
L
E
S
S
R
F
R
Y
S
T
E
Site 8
Y113
L
E
S
S
R
F
R
Y
S
T
E
L
A
P
G
Site 9
S114
E
S
S
R
F
R
Y
S
T
E
L
A
P
G
R
Site 10
T115
S
S
R
F
R
Y
S
T
E
L
A
P
G
R
G
Site 11
T126
P
G
R
G
D
M
P
T
L
T
D
N
T
H
G
Site 12
T128
R
G
D
M
P
T
L
T
D
N
T
H
G
R
Y
Site 13
Y135
T
D
N
T
H
G
R
Y
V
L
V
I
Y
E
N
Site 14
Y146
I
Y
E
N
L
L
K
Y
V
N
L
D
A
W
S
Site 15
S153
Y
V
N
L
D
A
W
S
R
E
L
L
D
R
Y
Site 16
Y160
S
R
E
L
L
D
R
Y
C
V
E
Y
G
V
G
Site 17
S178
F
F
R
A
H
E
H
S
L
L
S
A
Q
L
K
Site 18
S181
A
H
E
H
S
L
L
S
A
Q
L
K
G
F
P
Site 19
Y200
S
N
L
G
L
R
D
Y
Q
V
N
P
S
A
P
Site 20
T212
S
A
P
L
L
H
L
T
R
P
S
R
L
E
P
Site 21
S215
L
L
H
L
T
R
P
S
R
L
E
P
G
P
L
Site 22
T228
P
L
P
G
D
D
W
T
I
F
Q
S
N
H
S
Site 23
T236
I
F
Q
S
N
H
S
T
Y
E
P
V
L
L
A
Site 24
Y237
F
Q
S
N
H
S
T
Y
E
P
V
L
L
A
S
Site 25
T339
A
D
V
E
A
L
L
T
T
Q
N
K
L
R
T
Site 26
T346
T
T
Q
N
K
L
R
T
L
V
P
N
F
T
F
Site 27
Y362
L
G
F
S
G
K
F
Y
H
T
G
T
E
E
E
Site 28
S402
P
H
L
F
H
N
R
S
V
L
A
D
Q
M
R
Site 29
Y426
G
I
P
T
D
L
G
Y
A
V
A
P
H
H
S
Site 30
Y436
A
P
H
H
S
G
V
Y
P
I
H
T
Q
L
Y
Site 31
T440
S
G
V
Y
P
I
H
T
Q
L
Y
E
A
W
K
Site 32
Y443
Y
P
I
H
T
Q
L
Y
E
A
W
K
S
V
W
Site 33
Y460
Q
V
T
S
T
E
E
Y
P
H
L
R
P
A
R
Site 34
Y468
P
H
L
R
P
A
R
Y
R
R
G
F
I
H
N
Site 35
Y494
L
F
T
H
T
I
F
Y
N
E
Y
P
G
G
S
Site 36
Y497
H
T
I
F
Y
N
E
Y
P
G
G
S
R
E
L
Site 37
S507
G
S
R
E
L
D
R
S
I
R
G
G
E
L
F
Site 38
T527
N
P
I
S
I
F
M
T
H
L
S
N
Y
G
N
Site 39
Y532
F
M
T
H
L
S
N
Y
G
N
D
R
L
G
L
Site 40
Y540
G
N
D
R
L
G
L
Y
T
F
E
S
L
V
R
Site 41
T541
N
D
R
L
G
L
Y
T
F
E
S
L
V
R
F
Site 42
Y569
P
V
P
L
A
Q
K
Y
F
E
L
F
P
Q
E
Site 43
S578
E
L
F
P
Q
E
R
S
P
L
W
Q
N
P
C
Site 44
T599
D
I
W
S
K
E
K
T
C
D
R
L
P
K
F
Site 45
T630
L
S
L
H
P
A
V
T
S
S
F
P
S
P
S
Site 46
S631
S
L
H
P
A
V
T
S
S
F
P
S
P
S
T
Site 47
S632
L
H
P
A
V
T
S
S
F
P
S
P
S
T
F
Site 48
S635
A
V
T
S
S
F
P
S
P
S
T
F
E
E
I
Site 49
S637
T
S
S
F
P
S
P
S
T
F
E
E
I
Q
F
Site 50
T638
S
S
F
P
S
P
S
T
F
E
E
I
Q
F
F
Site 51
T669
P
V
P
S
N
A
S
T
D
F
L
F
E
K
S
Site 52
S676
T
D
F
L
F
E
K
S
A
T
Y
F
D
S
E
Site 53
Y679
L
F
E
K
S
A
T
Y
F
D
S
E
V
V
P
Site 54
S682
K
S
A
T
Y
F
D
S
E
V
V
P
R
R
G
Site 55
Y710
T
N
P
A
D
R
A
Y
S
W
Y
Q
H
Q
R
Site 56
S711
N
P
A
D
R
A
Y
S
W
Y
Q
H
Q
R
A
Site 57
Y713
A
D
R
A
Y
S
W
Y
Q
H
Q
R
A
H
G
Site 58
S734
Y
T
F
Y
Q
V
I
S
A
S
S
Q
T
P
L
Site 59
S737
Y
Q
V
I
S
A
S
S
Q
T
P
L
A
L
R
Site 60
Y755
N
R
C
L
V
P
G
Y
Y
S
T
H
L
Q
R
Site 61
Y756
R
C
L
V
P
G
Y
Y
S
T
H
L
Q
R
W
Site 62
T765
T
H
L
Q
R
W
L
T
Y
Y
P
S
G
Q
L
Site 63
Y766
H
L
Q
R
W
L
T
Y
Y
P
S
G
Q
L
L
Site 64
Y767
L
Q
R
W
L
T
Y
Y
P
S
G
Q
L
L
I
Site 65
Y803
G
I
T
P
F
L
N
Y
T
R
T
L
R
F
D
Site 66
T806
P
F
L
N
Y
T
R
T
L
R
F
D
D
D
K
Site 67
T825
Q
G
L
E
G
G
K
T
R
C
L
G
R
S
K
Site 68
S831
K
T
R
C
L
G
R
S
K
G
R
R
Y
P
D
Site 69
Y836
G
R
S
K
G
R
R
Y
P
D
M
D
T
E
S
Site 70
T841
R
R
Y
P
D
M
D
T
E
S
R
L
F
L
T
Site 71
S843
Y
P
D
M
D
T
E
S
R
L
F
L
T
D
F
Site 72
T848
T
E
S
R
L
F
L
T
D
F
F
R
N
H
N
Site 73
S859
R
N
H
N
L
E
L
S
K
L
L
S
R
L
G
Site 74
S871
R
L
G
Q
P
V
P
S
W
L
R
E
E
L
Q
Site 75
S880
L
R
E
E
L
Q
H
S
S
L
G
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation