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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
THOP1
Full Name:
Thimet oligopeptidase
Alias:
EC 3.4.24.15; Endo-oligopeptidase A; Endopeptidase 24.15; MEPD; MP78; PZ-peptidase; Soluble metallo-endopeptidase; Thimet oligopeptidase 1
Type:
Protease; EC 3.4.24.15
Mass (Da):
78840
Number AA:
689
UniProt ID:
P52888
International Prot ID:
IPI00549189
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
Uniprot
OncoNet
Molecular Function:
GO:0004222
GO:0005515
GO:0008270
PhosphoSite+
KinaseNET
Biological Process:
GO:0006508
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S16
G
D
M
A
D
A
A
S
P
C
S
V
V
N
D
Site 2
S19
A
D
A
A
S
P
C
S
V
V
N
D
L
R
W
Site 3
S29
N
D
L
R
W
D
L
S
A
Q
Q
I
E
E
R
Site 4
Y48
I
E
Q
T
K
R
V
Y
D
Q
V
G
T
Q
E
Site 5
S60
T
Q
E
F
E
D
V
S
Y
E
S
T
L
K
A
Site 6
Y61
Q
E
F
E
D
V
S
Y
E
S
T
L
K
A
L
Site 7
T64
E
D
V
S
Y
E
S
T
L
K
A
L
A
D
V
Site 8
T76
A
D
V
E
V
T
Y
T
V
Q
R
N
I
L
D
Site 9
S89
L
D
F
P
Q
H
V
S
P
S
K
D
I
R
T
Site 10
T96
S
P
S
K
D
I
R
T
A
S
T
E
A
D
K
Site 11
S98
S
K
D
I
R
T
A
S
T
E
A
D
K
K
L
Site 12
S113
S
E
F
D
V
E
M
S
M
R
E
D
V
Y
Q
Site 13
Y119
M
S
M
R
E
D
V
Y
Q
R
I
V
W
L
Q
Site 14
S133
Q
E
K
V
Q
K
D
S
L
R
P
E
A
A
R
Site 15
Y141
L
R
P
E
A
A
R
Y
L
E
R
L
I
K
L
Site 16
T160
G
L
H
L
P
R
E
T
Q
E
N
I
K
R
I
Site 17
S172
K
R
I
K
K
K
L
S
L
L
C
I
D
F
N
Site 18
T187
K
N
L
N
E
D
T
T
F
L
P
F
T
L
Q
Site 19
S206
L
P
E
D
F
L
N
S
L
E
K
M
E
D
G
Site 20
Y221
K
L
K
V
T
L
K
Y
P
H
Y
F
P
L
L
Site 21
Y224
V
T
L
K
Y
P
H
Y
F
P
L
L
K
K
C
Site 22
T236
K
K
C
H
V
P
E
T
R
R
K
V
E
E
A
Site 23
T261
A
I
L
K
E
L
V
T
L
R
A
Q
K
S
R
Site 24
S267
V
T
L
R
A
Q
K
S
R
L
L
G
F
H
T
Site 25
T274
S
R
L
L
G
F
H
T
H
A
D
Y
V
L
E
Site 26
Y278
G
F
H
T
H
A
D
Y
V
L
E
M
N
M
A
Site 27
S288
E
M
N
M
A
K
T
S
Q
T
V
A
T
F
L
Site 28
T290
N
M
A
K
T
S
Q
T
V
A
T
F
L
D
E
Site 29
T293
K
T
S
Q
T
V
A
T
F
L
D
E
L
A
Q
Site 30
Y340
R
A
W
D
M
R
Y
Y
M
N
Q
V
E
E
T
Site 31
T347
Y
M
N
Q
V
E
E
T
R
Y
C
V
D
Q
N
Site 32
Y349
N
Q
V
E
E
T
R
Y
C
V
D
Q
N
L
L
Site 33
Y359
D
Q
N
L
L
K
E
Y
F
P
V
Q
V
V
T
Site 34
Y397
W
H
E
D
V
R
L
Y
T
A
R
D
A
A
S
Site 35
T398
H
E
D
V
R
L
Y
T
A
R
D
A
A
S
G
Site 36
S404
Y
T
A
R
D
A
A
S
G
E
V
V
G
K
F
Site 37
Y412
G
E
V
V
G
K
F
Y
L
D
L
Y
P
R
E
Site 38
Y416
G
K
F
Y
L
D
L
Y
P
R
E
G
K
Y
G
Site 39
Y422
L
Y
P
R
E
G
K
Y
G
H
A
A
C
F
G
Site 40
S440
G
C
L
R
Q
D
G
S
R
Q
I
A
I
A
A
Site 41
Y471
Q
H
D
E
V
E
T
Y
F
H
E
F
G
H
V
Site 42
S505
R
D
F
V
E
A
P
S
Q
M
L
E
N
W
V
Site 43
S522
Q
E
P
L
L
R
M
S
R
H
Y
R
T
G
S
Site 44
Y525
L
L
R
M
S
R
H
Y
R
T
G
S
A
V
P
Site 45
S529
S
R
H
Y
R
T
G
S
A
V
P
R
E
L
L
Site 46
Y576
D
A
D
P
A
E
E
Y
A
R
L
C
Q
E
I
Site 47
T597
P
G
T
N
M
P
A
T
F
G
H
L
A
G
G
Site 48
Y605
F
G
H
L
A
G
G
Y
D
A
Q
Y
Y
G
Y
Site 49
Y609
A
G
G
Y
D
A
Q
Y
Y
G
Y
L
W
S
E
Site 50
Y610
G
G
Y
D
A
Q
Y
Y
G
Y
L
W
S
E
V
Site 51
Y612
Y
D
A
Q
Y
Y
G
Y
L
W
S
E
V
Y
S
Site 52
S635
K
Q
E
G
V
L
N
S
K
V
G
M
D
Y
R
Site 53
Y641
N
S
K
V
G
M
D
Y
R
S
C
I
L
R
P
Site 54
S643
K
V
G
M
D
Y
R
S
C
I
L
R
P
G
G
Site 55
S655
P
G
G
S
E
D
A
S
A
M
L
R
R
F
L
Site 56
S674
K
Q
D
A
F
L
L
S
K
G
L
Q
V
G
G
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation