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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PPP5C
Full Name:
Serine/threonine-protein phosphatase 5
Alias:
EC 3.1.3.16; PP5; PPP5; PPT; PP-T; Protein phosphatase 5, catalytic subunit; Protein phosphatase T; Serine/threonine protein phosphatase 5
Type:
Protein phosphatase, Ser/Thr (non-receptor); EC 3.1.3.16
Mass (Da):
56879
Number AA:
499
UniProt ID:
P53041
International Prot ID:
IPI00019812
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0005506
GO:0030145
GO:0004722
PhosphoSite+
KinaseNET
Biological Process:
GO:0007067
GO:0043123
GO:0006470
Phosida
TranscriptoNet
STRING
Kinexus Products
Serine/threonine protein phosphatase 5 pan-specific antibody AB-NP021-3#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-NP021-3#Serine/threonine protein phosphatase 5 pan-specific antibody AB-NP021-4#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-NP021-4
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T9
A
M
A
E
G
E
R
T
E
C
A
E
P
P
R
Site 2
T33
K
R
A
E
E
L
K
T
Q
A
N
D
Y
F
K
Site 3
Y38
L
K
T
Q
A
N
D
Y
F
K
A
K
D
Y
E
Site 4
Y44
D
Y
F
K
A
K
D
Y
E
N
A
I
K
F
Y
Site 5
S52
E
N
A
I
K
F
Y
S
Q
A
I
E
L
N
P
Site 6
Y64
L
N
P
S
N
A
I
Y
Y
G
N
R
S
L
A
Site 7
Y65
N
P
S
N
A
I
Y
Y
G
N
R
S
L
A
Y
Site 8
S69
A
I
Y
Y
G
N
R
S
L
A
Y
L
R
T
E
Site 9
Y72
Y
G
N
R
S
L
A
Y
L
R
T
E
C
Y
G
Site 10
T75
R
S
L
A
Y
L
R
T
E
C
Y
G
Y
A
L
Site 11
Y78
A
Y
L
R
T
E
C
Y
G
Y
A
L
G
D
A
Site 12
Y80
L
R
T
E
C
Y
G
Y
A
L
G
D
A
T
R
Site 13
T86
G
Y
A
L
G
D
A
T
R
A
I
E
L
D
K
Site 14
Y95
A
I
E
L
D
K
K
Y
I
K
G
Y
Y
R
R
Site 15
Y99
D
K
K
Y
I
K
G
Y
Y
R
R
A
A
S
N
Site 16
Y100
K
K
Y
I
K
G
Y
Y
R
R
A
A
S
N
M
Site 17
S105
G
Y
Y
R
R
A
A
S
N
M
A
L
G
K
F
Site 18
Y119
F
R
A
A
L
R
D
Y
E
T
V
V
K
V
K
Site 19
T121
A
A
L
R
D
Y
E
T
V
V
K
V
K
P
H
Site 20
Y136
D
K
D
A
K
M
K
Y
Q
E
C
N
K
I
V
Site 21
S160
A
G
D
E
H
K
R
S
V
V
D
S
L
D
I
Site 22
S164
H
K
R
S
V
V
D
S
L
D
I
E
S
M
T
Site 23
S169
V
D
S
L
D
I
E
S
M
T
I
E
D
E
Y
Site 24
T171
S
L
D
I
E
S
M
T
I
E
D
E
Y
S
G
Site 25
Y176
S
M
T
I
E
D
E
Y
S
G
P
K
L
E
D
Site 26
S177
M
T
I
E
D
E
Y
S
G
P
K
L
E
D
G
Site 27
S189
E
D
G
K
V
T
I
S
F
M
K
E
L
M
Q
Site 28
T238
L
K
E
T
E
K
I
T
V
C
G
D
T
H
G
Site 29
T243
K
I
T
V
C
G
D
T
H
G
Q
F
Y
D
L
Site 30
Y266
L
P
S
E
T
N
P
Y
I
F
N
G
D
F
V
Site 31
S277
G
D
F
V
D
R
G
S
F
S
V
E
V
I
L
Site 32
S279
F
V
D
R
G
S
F
S
V
E
V
I
L
T
L
Site 33
T285
F
S
V
E
V
I
L
T
L
F
G
F
K
L
L
Site 34
Y313
T
D
N
M
N
Q
I
Y
G
F
E
G
E
V
K
Site 35
Y323
E
G
E
V
K
A
K
Y
T
A
Q
M
Y
E
L
Site 36
Y328
A
K
Y
T
A
Q
M
Y
E
L
F
S
E
V
F
Site 37
T362
L
F
S
E
D
G
V
T
L
D
D
I
R
K
I
Site 38
S378
R
N
R
Q
P
P
D
S
G
P
M
C
D
L
L
Site 39
S387
P
M
C
D
L
L
W
S
D
P
Q
P
Q
N
G
Site 40
S396
P
Q
P
Q
N
G
R
S
I
S
K
R
G
V
S
Site 41
S398
P
Q
N
G
R
S
I
S
K
R
G
V
S
C
Q
Site 42
S403
S
I
S
K
R
G
V
S
C
Q
F
G
P
D
V
Site 43
Y422
L
E
E
N
N
L
D
Y
I
I
R
S
H
E
V
Site 44
Y434
H
E
V
K
A
E
G
Y
E
V
A
H
G
G
R
Site 45
T444
A
H
G
G
R
C
V
T
V
F
S
A
P
N
Y
Site 46
Y451
T
V
F
S
A
P
N
Y
C
D
Q
M
G
N
K
Site 47
S460
D
Q
M
G
N
K
A
S
Y
I
H
L
Q
G
S
Site 48
Y461
Q
M
G
N
K
A
S
Y
I
H
L
Q
G
S
D
Site 49
S467
S
Y
I
H
L
Q
G
S
D
L
R
P
Q
F
H
Site 50
T477
R
P
Q
F
H
Q
F
T
A
V
P
H
P
N
V
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation