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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
DAPK1
Full Name:
Death-associated protein kinase 1
Alias:
DAP kinase 1; DAPK; Death associated protein kinase; EC 2.7.11.1; Kinase DAPK1
Type:
EC 2.7.11.1; Autophagy; Apoptosis; Protein kinase, Ser/Thr (non-receptor); CAMK group; DAPK family
Mass (Da):
160073
Number AA:
1430
UniProt ID:
P53355
International Prot ID:
IPI00021250
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0015629
GO:0005737
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0005516
GO:0004674
PhosphoSite+
KinaseNET
Biological Process:
GO:0006915
GO:0008624
GO:0006468
Phosida
TranscriptoNet
STRING
Kinexus Products
MYL9 (12-23) KinSub - Myosin light chain 9 (A12-S23, human) peptide; PHKG protein kinase substrate peptide - Powder PE-01ADE95#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-01ADE95
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y12
R
Q
E
N
V
D
D
Y
Y
D
T
G
E
E
L
Site 2
Y13
Q
E
N
V
D
D
Y
Y
D
T
G
E
E
L
G
Site 3
T15
N
V
D
D
Y
Y
D
T
G
E
E
L
G
S
G
Site 4
S34
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
Site 5
Y39
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
Site 6
T49
K
F
I
K
K
R
R
T
K
S
S
R
R
G
V
Site 7
S51
I
K
K
R
R
T
K
S
S
R
R
G
V
S
R
Site 8
S52
K
K
R
R
T
K
S
S
R
R
G
V
S
R
E
Site 9
S57
K
S
S
R
R
G
V
S
R
E
D
I
E
R
E
Site 10
S66
E
D
I
E
R
E
V
S
I
L
K
E
I
Q
H
Site 11
S110
D
F
L
A
E
K
E
S
L
T
E
E
E
A
T
Site 12
T117
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
Site 13
T180
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
Site 14
T221
A
S
P
F
L
G
D
T
K
Q
E
T
L
A
N
Site 15
T225
L
G
D
T
K
Q
E
T
L
A
N
V
S
A
V
Site 16
Y234
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
Site 17
Y240
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
Site 18
S242
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
Site 19
T265
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
Site 20
T280
P
W
I
K
P
K
D
T
Q
Q
A
L
S
R
K
Site 21
S285
K
D
T
Q
Q
A
L
S
R
K
A
S
A
V
N
Site 22
S289
Q
A
L
S
R
K
A
S
A
V
N
M
E
K
F
Site 23
S308
A
R
K
K
W
K
Q
S
V
R
L
I
S
L
C
Site 24
S313
K
Q
S
V
R
L
I
S
L
C
Q
R
L
S
R
Site 25
S319
I
S
L
C
Q
R
L
S
R
S
F
L
S
R
S
Site 26
S321
L
C
Q
R
L
S
R
S
F
L
S
R
S
N
M
Site 27
S324
R
L
S
R
S
F
L
S
R
S
N
M
S
V
A
Site 28
S326
S
R
S
F
L
S
R
S
N
M
S
V
A
R
S
Site 29
S329
F
L
S
R
S
N
M
S
V
A
R
S
D
D
T
Site 30
S333
S
N
M
S
V
A
R
S
D
D
T
L
D
E
E
Site 31
T336
S
V
A
R
S
D
D
T
L
D
E
E
D
S
F
Site 32
S342
D
T
L
D
E
E
D
S
F
V
M
K
A
I
I
Site 33
S366
G
L
Q
H
L
L
G
S
L
S
N
Y
D
V
N
Site 34
S368
Q
H
L
L
G
S
L
S
N
Y
D
V
N
Q
P
Site 35
Y370
L
L
G
S
L
S
N
Y
D
V
N
Q
P
N
K
Site 36
T380
N
Q
P
N
K
H
G
T
P
P
L
L
I
A
A
Site 37
S403
Q
L
L
I
K
R
G
S
R
I
D
V
Q
D
K
Site 38
Y417
K
G
G
S
N
A
V
Y
W
A
A
R
H
G
H
Site 39
T427
A
R
H
G
H
V
D
T
L
K
F
L
S
E
N
Site 40
S432
V
D
T
L
K
F
L
S
E
N
K
C
P
L
D
Site 41
S444
P
L
D
V
K
D
K
S
G
E
M
A
L
H
V
Site 42
S469
Q
L
L
C
S
F
G
S
N
P
N
I
Q
D
K
Site 43
T480
I
Q
D
K
E
E
E
T
P
L
H
C
A
A
W
Site 44
Y490
H
C
A
A
W
H
G
Y
Y
S
V
A
K
A
L
Site 45
Y491
C
A
A
W
H
G
Y
Y
S
V
A
K
A
L
C
Site 46
T513
I
K
N
R
E
G
E
T
P
L
L
T
A
S
A
Site 47
T517
E
G
E
T
P
L
L
T
A
S
A
R
G
Y
H
Site 48
S519
E
T
P
L
L
T
A
S
A
R
G
Y
H
D
I
Site 49
Y572
S
Q
G
C
F
V
D
Y
Q
D
R
H
G
N
T
Site 50
T579
Y
Q
D
R
H
G
N
T
P
L
H
V
A
C
K
Site 51
Y609
N
L
D
I
S
N
K
Y
G
R
T
P
L
H
L
Site 52
T612
I
S
N
K
Y
G
R
T
P
L
H
L
A
A
N
Site 53
T641
A
S
V
E
A
L
T
T
D
G
K
T
A
E
D
Site 54
T669
L
A
R
L
R
K
D
T
H
R
G
L
F
I
Q
Site 55
T681
F
I
Q
Q
L
R
P
T
Q
N
L
Q
P
R
I
Site 56
T702
H
S
G
S
G
K
T
T
L
V
E
S
L
K
C
Site 57
S714
L
K
C
G
L
L
R
S
F
F
R
R
R
R
P
Site 58
S724
R
R
R
R
P
R
L
S
S
T
N
S
S
R
F
Site 59
S725
R
R
R
P
R
L
S
S
T
N
S
S
R
F
P
Site 60
T726
R
R
P
R
L
S
S
T
N
S
S
R
F
P
P
Site 61
S728
P
R
L
S
S
T
N
S
S
R
F
P
P
S
P
Site 62
S729
R
L
S
S
T
N
S
S
R
F
P
P
S
P
L
Site 63
S734
N
S
S
R
F
P
P
S
P
L
A
S
K
P
T
Site 64
S738
F
P
P
S
P
L
A
S
K
P
T
V
S
V
S
Site 65
T741
S
P
L
A
S
K
P
T
V
S
V
S
I
N
N
Site 66
S745
S
K
P
T
V
S
V
S
I
N
N
L
Y
P
G
Site 67
Y750
S
V
S
I
N
N
L
Y
P
G
C
E
N
V
S
Site 68
S757
Y
P
G
C
E
N
V
S
V
R
S
R
S
M
M
Site 69
S762
N
V
S
V
R
S
R
S
M
M
F
E
P
G
L
Site 70
S787
P
T
H
H
P
H
C
S
A
D
D
Q
S
T
K
Site 71
S792
H
C
S
A
D
D
Q
S
T
K
A
I
D
I
Q
Site 72
S810
L
N
G
V
G
D
F
S
V
W
E
F
S
G
N
Site 73
Y820
E
F
S
G
N
P
V
Y
F
C
C
Y
D
Y
F
Site 74
Y904
P
A
G
G
E
F
G
Y
D
K
D
T
S
L
L
Site 75
T908
E
F
G
Y
D
K
D
T
S
L
L
K
E
I
R
Site 76
S909
F
G
Y
D
K
D
T
S
L
L
K
E
I
R
N
Site 77
S938
L
D
A
G
A
S
G
S
K
D
M
K
V
L
R
Site 78
S953
N
H
L
Q
E
I
R
S
Q
I
V
S
V
C
P
Site 79
S957
E
I
R
S
Q
I
V
S
V
C
P
P
M
T
H
Site 80
S971
H
L
C
E
K
I
I
S
T
L
P
S
W
R
K
Site 81
S975
K
I
I
S
T
L
P
S
W
R
K
L
N
G
P
Site 82
Y993
M
S
L
Q
Q
F
V
Y
D
V
Q
D
Q
L
N
Site 83
S1004
D
Q
L
N
P
L
A
S
E
E
D
L
R
R
I
Site 84
T1053
G
K
L
L
S
V
E
T
P
R
A
L
H
H
Y
Site 85
Y1060
T
P
R
A
L
H
H
Y
R
G
R
Y
T
V
E
Site 86
Y1064
L
H
H
Y
R
G
R
Y
T
V
E
D
I
Q
R
Site 87
T1065
H
H
Y
R
G
R
Y
T
V
E
D
I
Q
R
L
Site 88
S1076
I
Q
R
L
V
P
D
S
D
V
E
E
L
L
Q
Site 89
S1115
K
T
D
N
L
H
R
S
W
A
D
E
E
D
E
Site 90
Y1236
G
L
L
T
V
K
H
Y
L
S
P
Q
Q
L
R
Site 91
S1238
L
T
V
K
H
Y
L
S
P
Q
Q
L
R
E
H
Site 92
Y1252
H
H
E
P
V
M
I
Y
Q
P
R
D
F
F
R
Site 93
T1262
R
D
F
F
R
A
Q
T
L
K
E
T
S
L
T
Site 94
S1267
A
Q
T
L
K
E
T
S
L
T
N
T
M
G
G
Site 95
T1269
T
L
K
E
T
S
L
T
N
T
M
G
G
Y
K
Site 96
T1271
K
E
T
S
L
T
N
T
M
G
G
Y
K
E
S
Site 97
Y1275
L
T
N
T
M
G
G
Y
K
E
S
F
S
S
I
Site 98
T1309
A
S
D
L
N
L
L
T
R
R
K
L
S
R
L
Site 99
S1314
L
L
T
R
R
K
L
S
R
L
L
D
P
P
D
Site 100
Y1343
L
P
D
L
V
A
K
Y
N
T
N
N
G
A
P
Site 101
T1345
D
L
V
A
K
Y
N
T
N
N
G
A
P
K
D
Site 102
S1356
A
P
K
D
F
L
P
S
P
L
H
A
L
L
R
Site 103
T1366
H
A
L
L
R
E
W
T
T
Y
P
E
S
T
V
Site 104
Y1368
L
L
R
E
W
T
T
Y
P
E
S
T
V
G
T
Site 105
S1371
E
W
T
T
Y
P
E
S
T
V
G
T
L
M
S
Site 106
T1375
Y
P
E
S
T
V
G
T
L
M
S
K
L
R
E
Site 107
S1378
S
T
V
G
T
L
M
S
K
L
R
E
L
G
R
Site 108
Y1411
D
G
N
G
Q
E
A
Y
A
S
S
C
N
S
G
Site 109
S1413
N
G
Q
E
A
Y
A
S
S
C
N
S
G
T
S
Site 110
S1414
G
Q
E
A
Y
A
S
S
C
N
S
G
T
S
Y
Site 111
S1417
A
Y
A
S
S
C
N
S
G
T
S
Y
N
S
I
Site 112
T1419
A
S
S
C
N
S
G
T
S
Y
N
S
I
S
S
Site 113
S1420
S
S
C
N
S
G
T
S
Y
N
S
I
S
S
V
Site 114
Y1421
S
C
N
S
G
T
S
Y
N
S
I
S
S
V
V
Site 115
S1423
N
S
G
T
S
Y
N
S
I
S
S
V
V
S
R
Site 116
S1425
G
T
S
Y
N
S
I
S
S
V
V
S
R
_
_
Site 117
S1426
T
S
Y
N
S
I
S
S
V
V
S
R
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation