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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
METAP1
Full Name:
Methionine aminopeptidase 1
Alias:
AMP1; AMPM1; KIAA0094; MAP 1; Methionyl aminopeptidase 1; Peptidase M 1
Type:
Protease; EC 3.4.11.18
Mass (Da):
43215
Number AA:
386
UniProt ID:
P53582
International Prot ID:
IPI00022239
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
Uniprot
OncoNet
Molecular Function:
GO:0004177
GO:0050897
GO:0008235
PhosphoSite+
KinaseNET
Biological Process:
GO:0031365
GO:0018206
GO:0006508
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S15
V
C
E
T
D
G
C
S
S
E
A
K
L
Q
C
Site 2
S33
I
K
L
G
I
Q
G
S
Y
F
C
S
Q
E
C
Site 3
Y34
K
L
G
I
Q
G
S
Y
F
C
S
Q
E
C
F
Site 4
S65
E
K
A
K
R
E
V
S
S
W
T
V
E
G
D
Site 5
T68
K
R
E
V
S
S
W
T
V
E
G
D
I
N
T
Site 6
T75
T
V
E
G
D
I
N
T
D
P
W
A
G
Y
R
Site 7
Y83
D
P
W
A
G
Y
R
Y
T
G
K
L
R
P
H
Site 8
T84
P
W
A
G
Y
R
Y
T
G
K
L
R
P
H
Y
Site 9
Y91
T
G
K
L
R
P
H
Y
P
L
M
P
T
R
P
Site 10
T96
P
H
Y
P
L
M
P
T
R
P
V
P
S
Y
I
Site 11
S101
M
P
T
R
P
V
P
S
Y
I
Q
R
P
D
Y
Site 12
Y102
P
T
R
P
V
P
S
Y
I
Q
R
P
D
Y
A
Site 13
Y108
S
Y
I
Q
R
P
D
Y
A
D
H
P
L
G
M
Site 14
S118
H
P
L
G
M
S
E
S
E
Q
A
L
K
G
T
Site 15
S126
E
Q
A
L
K
G
T
S
Q
I
K
L
L
S
S
Site 16
S132
T
S
Q
I
K
L
L
S
S
E
D
I
E
G
M
Site 17
S133
S
Q
I
K
L
L
S
S
E
D
I
E
G
M
R
Site 18
Y180
A
C
I
A
R
N
C
Y
P
S
P
L
N
Y
Y
Site 19
Y186
C
Y
P
S
P
L
N
Y
Y
N
F
P
K
S
C
Site 20
Y187
Y
P
S
P
L
N
Y
Y
N
F
P
K
S
C
C
Site 21
Y224
V
N
V
D
I
T
L
Y
R
N
G
Y
H
G
D
Site 22
Y228
I
T
L
Y
R
N
G
Y
H
G
D
L
N
E
T
Site 23
T251
G
A
R
K
L
V
Q
T
T
Y
E
C
L
M
Q
Site 24
Y253
R
K
L
V
Q
T
T
Y
E
C
L
M
Q
A
I
Site 25
Y291
G
F
S
V
V
R
S
Y
C
G
H
G
I
H
K
Site 26
T302
G
I
H
K
L
F
H
T
A
P
N
V
P
H
Y
Site 27
Y309
T
A
P
N
V
P
H
Y
A
K
N
K
A
V
G
Site 28
T345
E
T
W
P
D
G
W
T
A
V
T
R
D
G
K
Site 29
S354
V
T
R
D
G
K
R
S
A
Q
F
E
H
T
L
Site 30
T372
D
T
G
C
E
I
L
T
R
R
L
D
S
A
R
Site 31
S377
I
L
T
R
R
L
D
S
A
R
P
H
F
M
S
Site 32
S384
S
A
R
P
H
F
M
S
Q
F
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation