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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
MVD
Full Name:
Diphosphomevalonate decarboxylase
Alias:
ERG19; Mevalonate (diphospho) decarboxylase; Mevalonate pyrophosphate decarboxylase; MPD
Type:
Secondary Metabolites Metabolism - terpenoid backbone biosynthesis; EC 4.1.1.33; Lyase
Mass (Da):
43405
Number AA:
400
UniProt ID:
P53602
International Prot ID:
IPI00022745
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005829
GO:0044424
GO:0044444
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0030544
GO:0004163
PhosphoSite+
KinaseNET
Biological Process:
GO:0006695
GO:0008299
GO:0016310
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S40
L
P
I
N
S
S
L
S
V
T
L
H
Q
D
Q
Site 2
T42
I
N
S
S
L
S
V
T
L
H
Q
D
Q
L
K
Site 3
T50
L
H
Q
D
Q
L
K
T
T
T
T
A
V
I
S
Site 4
T53
D
Q
L
K
T
T
T
T
A
V
I
S
K
D
F
Site 5
T61
A
V
I
S
K
D
F
T
E
D
R
I
W
L
N
Site 6
S96
L
A
R
K
R
R
N
S
R
D
G
D
P
L
P
Site 7
S105
D
G
D
P
L
P
S
S
L
S
C
K
V
H
V
Site 8
S107
D
P
L
P
S
S
L
S
C
K
V
H
V
A
S
Site 9
Y131
L
A
S
S
A
A
G
Y
A
C
L
A
Y
T
L
Site 10
S146
A
R
V
Y
G
V
E
S
D
L
S
E
V
A
R
Site 11
S149
Y
G
V
E
S
D
L
S
E
V
A
R
R
G
S
Site 12
S156
S
E
V
A
R
R
G
S
G
S
A
C
R
S
L
Site 13
S158
V
A
R
R
G
S
G
S
A
C
R
S
L
Y
G
Site 14
S162
G
S
G
S
A
C
R
S
L
Y
G
G
F
V
E
Site 15
Y164
G
S
A
C
R
S
L
Y
G
G
F
V
E
W
Q
Site 16
S181
E
Q
A
D
G
K
D
S
I
A
R
Q
V
A
P
Site 17
S190
A
R
Q
V
A
P
E
S
H
W
P
E
L
R
V
Site 18
T209
V
S
A
E
K
K
L
T
G
S
T
V
G
M
R
Site 19
S211
A
E
K
K
L
T
G
S
T
V
G
M
R
A
S
Site 20
T212
E
K
K
L
T
G
S
T
V
G
M
R
A
S
V
Site 21
T221
G
M
R
A
S
V
E
T
S
P
L
L
R
F
R
Site 22
S222
M
R
A
S
V
E
T
S
P
L
L
R
F
R
A
Site 23
S251
I
R
E
R
D
F
P
S
F
A
Q
L
T
M
K
Site 24
T256
F
P
S
F
A
Q
L
T
M
K
D
S
N
Q
F
Site 25
Y276
D
T
F
P
P
I
S
Y
L
N
A
I
S
W
R
Site 26
Y302
H
G
D
T
K
V
A
Y
T
F
D
A
G
P
N
Site 27
T303
G
D
T
K
V
A
Y
T
F
D
A
G
P
N
A
Site 28
S334
W
H
G
F
P
P
G
S
N
G
D
T
F
L
K
Site 29
T338
P
P
G
S
N
G
D
T
F
L
K
G
L
Q
V
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation