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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
COPA
Full Name:
Coatomer subunit alpha
Alias:
Alpha-coat protein; Alpha-COP; Xenopsin-related peptide
Type:
Vesicle protein
Mass (Da):
138346
Number AA:
1224
UniProt ID:
P53621
International Prot ID:
IPI00295857
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0030126
GO:0005829
GO:0005783
Uniprot
OncoNet
Molecular Function:
GO:0005509
GO:0005179
GO:0005198
PhosphoSite+
KinaseNET
Biological Process:
GO:0048205
GO:0006886
GO:0030157
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S9
L
T
K
F
E
T
K
S
A
R
V
K
G
L
S
Site 2
S16
S
A
R
V
K
G
L
S
F
H
P
K
R
P
W
Site 3
T26
P
K
R
P
W
I
L
T
S
L
H
N
G
V
I
Site 4
S27
K
R
P
W
I
L
T
S
L
H
N
G
V
I
Q
Site 5
Y73
F
V
S
G
G
D
D
Y
K
I
K
V
W
N
Y
Site 6
Y80
Y
K
I
K
V
W
N
Y
K
L
R
R
C
L
F
Site 7
Y95
T
L
L
G
H
L
D
Y
I
R
T
T
F
F
H
Site 8
S110
H
E
Y
P
W
I
L
S
A
S
D
D
Q
T
I
Site 9
S112
Y
P
W
I
L
S
A
S
D
D
Q
T
I
R
V
Site 10
S165
T
V
R
V
W
D
I
S
G
L
R
K
K
N
L
Site 11
S173
G
L
R
K
K
N
L
S
P
G
A
V
E
S
D
Site 12
S179
L
S
P
G
A
V
E
S
D
V
R
G
I
T
G
Site 13
T185
E
S
D
V
R
G
I
T
G
V
D
L
F
G
T
Site 14
T193
G
V
D
L
F
G
T
T
D
A
V
V
K
H
V
Site 15
S222
P
T
M
P
L
I
V
S
G
A
D
D
R
Q
V
Site 16
T244
S
K
A
W
E
V
D
T
C
R
G
H
Y
N
N
Site 17
Y249
V
D
T
C
R
G
H
Y
N
N
V
S
C
A
V
Site 18
S266
P
R
Q
E
L
I
L
S
N
S
E
D
K
S
I
Site 19
S268
Q
E
L
I
L
S
N
S
E
D
K
S
I
R
V
Site 20
S272
L
S
N
S
E
D
K
S
I
R
V
W
D
M
S
Site 21
S279
S
I
R
V
W
D
M
S
K
R
T
G
V
Q
T
Site 22
T286
S
K
R
T
G
V
Q
T
F
R
R
D
H
D
R
Site 23
Y326
L
E
R
E
R
P
A
Y
A
V
H
G
N
M
L
Site 24
Y335
V
H
G
N
M
L
H
Y
V
K
D
R
F
L
R
Site 25
S348
L
R
Q
L
D
F
N
S
S
K
D
V
A
V
M
Site 26
S349
R
Q
L
D
F
N
S
S
K
D
V
A
V
M
Q
Site 27
S384
V
L
L
C
T
R
A
S
N
L
E
N
S
T
Y
Site 28
S389
R
A
S
N
L
E
N
S
T
Y
D
L
Y
T
I
Site 29
Y391
S
N
L
E
N
S
T
Y
D
L
Y
T
I
P
K
Site 30
Y394
E
N
S
T
Y
D
L
Y
T
I
P
K
D
A
D
Site 31
S402
T
I
P
K
D
A
D
S
Q
N
P
D
A
P
E
Site 32
S413
D
A
P
E
G
K
R
S
S
G
L
T
A
V
W
Site 33
S414
A
P
E
G
K
R
S
S
G
L
T
A
V
W
V
Site 34
T417
G
K
R
S
S
G
L
T
A
V
W
V
A
R
N
Site 35
T473
L
R
D
A
D
S
I
T
L
F
D
V
Q
Q
K
Site 36
S485
Q
Q
K
R
T
L
A
S
V
K
I
S
K
V
K
Site 37
S532
H
E
N
I
R
V
K
S
G
A
W
D
E
S
G
Site 38
Y543
D
E
S
G
V
F
I
Y
T
T
S
N
H
I
K
Site 39
T544
E
S
G
V
F
I
Y
T
T
S
N
H
I
K
Y
Site 40
Y551
T
T
S
N
H
I
K
Y
A
V
T
T
G
D
H
Site 41
Y569
R
T
L
D
L
P
I
Y
V
T
R
V
K
G
N
Site 42
Y579
R
V
K
G
N
N
V
Y
C
L
D
R
E
C
R
Site 43
T591
E
C
R
P
R
V
L
T
I
D
P
T
E
F
K
Site 44
Y628
V
G
Q
S
I
I
A
Y
L
Q
K
K
G
Y
P
Site 45
Y634
A
Y
L
Q
K
K
G
Y
P
E
V
A
L
H
F
Site 46
S650
K
D
E
K
T
R
F
S
L
A
L
E
C
G
N
Site 47
Y733
R
K
D
M
S
G
H
Y
Q
N
A
L
Y
L
G
Site 48
Y738
G
H
Y
Q
N
A
L
Y
L
G
D
V
S
E
R
Site 49
S756
L
K
N
C
G
Q
K
S
L
A
Y
L
T
A
A
Site 50
Y759
C
G
Q
K
S
L
A
Y
L
T
A
A
T
H
G
Site 51
S773
G
L
D
E
E
A
E
S
L
K
E
T
F
D
P
Site 52
T777
E
A
E
S
L
K
E
T
F
D
P
E
K
E
T
Site 53
T812
D
T
N
W
P
L
L
T
V
S
K
G
F
F
E
Site 54
T821
S
K
G
F
F
E
G
T
I
A
S
K
G
K
G
Site 55
T839
A
A
D
I
D
I
D
T
V
G
T
E
G
W
G
Site 56
S895
L
P
P
E
L
D
I
S
P
G
A
A
G
G
A
Site 57
T911
D
G
F
F
V
P
P
T
K
G
T
S
P
T
Q
Site 58
S915
V
P
P
T
K
G
T
S
P
T
Q
I
W
C
N
Site 59
S924
T
Q
I
W
C
N
N
S
Q
L
P
V
D
H
I
Site 60
Y963
K
Q
L
F
L
Q
T
Y
A
R
G
R
T
T
Y
Site 61
T968
Q
T
Y
A
R
G
R
T
T
Y
Q
A
L
P
C
Site 62
T969
T
Y
A
R
G
R
T
T
Y
Q
A
L
P
C
L
Site 63
Y970
Y
A
R
G
R
T
T
Y
Q
A
L
P
C
L
P
Site 64
S978
Q
A
L
P
C
L
P
S
M
Y
G
Y
P
N
R
Site 65
Y980
L
P
C
L
P
S
M
Y
G
Y
P
N
R
N
W
Site 66
S1035
K
F
R
S
I
L
L
S
V
P
L
L
V
V
D
Site 67
Y1090
R
I
C
E
M
A
A
Y
F
T
H
S
N
L
Q
Site 68
T1120
F
K
L
K
N
F
K
T
A
A
T
F
A
R
R
Site 69
T1123
K
N
F
K
T
A
A
T
F
A
R
R
L
L
E
Site 70
T1153
S
A
C
E
K
N
P
T
D
A
Y
Q
L
N
Y
Site 71
Y1156
E
K
N
P
T
D
A
Y
Q
L
N
Y
D
M
H
Site 72
Y1160
T
D
A
Y
Q
L
N
Y
D
M
H
N
P
F
D
Site 73
Y1177
A
A
S
Y
R
P
I
Y
R
G
K
P
V
E
K
Site 74
S1188
P
V
E
K
C
P
L
S
G
A
C
Y
S
P
E
Site 75
Y1192
C
P
L
S
G
A
C
Y
S
P
E
F
K
G
Q
Site 76
S1193
P
L
S
G
A
C
Y
S
P
E
F
K
G
Q
I
Site 77
T1204
K
G
Q
I
C
R
V
T
T
V
T
E
I
G
K
Site 78
T1205
G
Q
I
C
R
V
T
T
V
T
E
I
G
K
D
Site 79
T1207
I
C
R
V
T
T
V
T
E
I
G
K
D
V
I
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation