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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
HCCS
Full Name:
Cytochrome c-type heme lyase
Alias:
CCHL; Cytochrome c heme-lyase; Holocytochrome c synthase
Type:
Cofactor and Vitamin Metabolism - porphyrin and chlorophyll; Mitochondrial; Lyase; EC 4.4.1.17
Mass (Da):
30602
Number AA:
268
UniProt ID:
P53701
International Prot ID:
IPI00023406
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005743
Uniprot
OncoNet
Molecular Function:
GO:0004408
GO:0005506
PhosphoSite+
KinaseNET
Biological Process:
GO:0009887
GO:0055114
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S18
A
V
Q
A
S
N
A
S
A
S
P
P
S
G
C
Site 2
S20
Q
A
S
N
A
S
A
S
P
P
S
G
C
P
M
Site 3
S23
N
A
S
A
S
P
P
S
G
C
P
M
H
E
G
Site 4
T39
M
K
G
C
P
V
N
T
E
P
S
G
P
T
C
Site 5
T50
G
P
T
C
E
K
K
T
Y
S
V
P
A
H
Q
Site 6
Y51
P
T
C
E
K
K
T
Y
S
V
P
A
H
Q
E
Site 7
S52
T
C
E
K
K
T
Y
S
V
P
A
H
Q
E
R
Site 8
Y61
P
A
H
Q
E
R
A
Y
E
Y
V
E
C
P
I
Site 9
Y63
H
Q
E
R
A
Y
E
Y
V
E
C
P
I
R
G
Site 10
T71
V
E
C
P
I
R
G
T
A
A
E
N
K
E
N
Site 11
S82
N
K
E
N
L
D
P
S
N
L
M
P
P
P
N
Site 12
T91
L
M
P
P
P
N
Q
T
P
A
P
D
Q
P
F
Site 13
S101
P
D
Q
P
F
A
L
S
T
V
R
E
E
S
S
Site 14
T102
D
Q
P
F
A
L
S
T
V
R
E
E
S
S
I
Site 15
S107
L
S
T
V
R
E
E
S
S
I
P
R
A
D
S
Site 16
S114
S
S
I
P
R
A
D
S
E
K
K
W
V
Y
P
Site 17
Y148
D
I
S
Q
K
D
M
Y
N
I
I
R
I
H
N
Site 18
S181
A
E
C
P
C
G
P
S
L
I
R
F
G
G
K
Site 19
Y192
F
G
G
K
A
K
E
Y
S
P
R
A
R
I
R
Site 20
S193
G
G
K
A
K
E
Y
S
P
R
A
R
I
R
S
Site 21
S200
S
P
R
A
R
I
R
S
W
M
G
Y
E
L
P
Site 22
Y204
R
I
R
S
W
M
G
Y
E
L
P
F
D
R
H
Site 23
Y224
R
C
G
T
E
V
R
Y
V
I
D
Y
Y
D
G
Site 24
Y228
E
V
R
Y
V
I
D
Y
Y
D
G
G
E
V
N
Site 25
Y229
V
R
Y
V
I
D
Y
Y
D
G
G
E
V
N
K
Site 26
Y238
G
G
E
V
N
K
D
Y
Q
F
T
I
L
D
V
Site 27
S251
D
V
R
P
A
L
D
S
L
S
A
V
W
D
R
Site 28
S253
R
P
A
L
D
S
L
S
A
V
W
D
R
M
K
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation