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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
KIAA0174
Full Name:
IST1 homolog
Alias:
Increased sodium tolerance-1; IST1; K0174
Type:
Unknown function
Mass (Da):
39751
Number AA:
364
UniProt ID:
P53990
International Prot ID:
IPI00024660
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005793
GO:0016023
Uniprot
OncoNet
Molecular Function:
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0007049
GO:0051301
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T30
K
L
L
E
K
K
K
T
E
L
A
Q
K
A
R
Site 2
Y43
A
R
K
E
I
A
D
Y
L
A
A
G
K
D
E
Site 3
Y64
E
H
I
I
R
E
D
Y
L
V
E
A
M
E
I
Site 4
S88
A
R
F
G
L
I
Q
S
M
K
E
L
D
S
G
Site 5
S94
Q
S
M
K
E
L
D
S
G
L
A
E
S
V
S
Site 6
S112
W
A
A
P
R
L
Q
S
E
V
A
E
L
K
I
Site 7
S153
D
R
L
M
H
K
L
S
V
E
A
P
P
K
I
Site 8
Y173
L
I
E
I
A
K
N
Y
N
V
P
Y
E
P
D
Site 9
Y177
A
K
N
Y
N
V
P
Y
E
P
D
S
V
V
M
Site 10
S181
N
V
P
Y
E
P
D
S
V
V
M
A
E
A
P
Site 11
S214
G
G
P
G
R
G
G
S
G
G
F
T
A
P
V
Site 12
T218
R
G
G
S
G
G
F
T
A
P
V
G
G
P
D
Site 13
T227
P
V
G
G
P
D
G
T
V
P
M
P
M
P
M
Site 14
S238
P
M
P
M
P
M
P
S
A
N
T
P
F
S
Y
Site 15
T241
M
P
M
P
S
A
N
T
P
F
S
Y
P
L
P
Site 16
S244
P
S
A
N
T
P
F
S
Y
P
L
P
K
G
P
Site 17
Y245
S
A
N
T
P
F
S
Y
P
L
P
K
G
P
S
Site 18
S252
Y
P
L
P
K
G
P
S
D
F
N
G
L
P
M
Site 19
Y262
N
G
L
P
M
G
T
Y
Q
A
F
P
N
I
H
Site 20
T276
H
P
P
Q
I
P
A
T
P
P
S
Y
E
S
V
Site 21
S279
Q
I
P
A
T
P
P
S
Y
E
S
V
D
D
I
Site 22
Y280
I
P
A
T
P
P
S
Y
E
S
V
D
D
I
N
Site 23
S282
A
T
P
P
S
Y
E
S
V
D
D
I
N
A
D
Site 24
S293
I
N
A
D
K
N
I
S
S
A
Q
I
V
G
P
Site 25
S294
N
A
D
K
N
I
S
S
A
Q
I
V
G
P
G
Site 26
S307
P
G
P
K
P
E
A
S
A
K
L
P
S
R
P
Site 27
Y318
P
S
R
P
A
D
N
Y
D
N
F
V
L
P
E
Site 28
T332
E
L
P
S
V
P
D
T
L
P
T
A
S
A
G
Site 29
S337
P
D
T
L
P
T
A
S
A
G
A
S
T
S
A
Site 30
S341
P
T
A
S
A
G
A
S
T
S
A
S
E
D
I
Site 31
S343
A
S
A
G
A
S
T
S
A
S
E
D
I
D
F
Site 32
S345
A
G
A
S
T
S
A
S
E
D
I
D
F
D
D
Site 33
S354
D
I
D
F
D
D
L
S
R
R
F
E
E
L
K
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation