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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
POLG
Full Name:
DNA polymerase subunit gamma-1
Alias:
Mitochondrial DNA polymerase catalytic subunit;PolG-alpha
Type:
Mass (Da):
139562
Number AA:
1239
UniProt ID:
P54098
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T13
W
R
K
V
A
G
A
T
V
G
P
G
P
V
P
Site 2
S27
P
A
P
G
R
W
V
S
S
S
V
P
A
S
D
Site 3
S29
P
G
R
W
V
S
S
S
V
P
A
S
D
P
S
Site 4
S33
V
S
S
S
V
P
A
S
D
P
S
D
G
Q
R
Site 5
S36
S
V
P
A
S
D
P
S
D
G
Q
R
R
R
Q
Site 6
S64
Q
Q
P
Q
V
L
S
S
E
G
G
Q
L
R
H
Site 7
S103
G
E
A
A
V
R
R
S
V
E
H
L
Q
K
H
Site 8
Y131
E
L
R
L
P
P
L
Y
G
D
N
L
D
Q
H
Site 9
S147
R
L
L
A
Q
K
Q
S
L
P
Y
L
E
A
A
Site 10
Y233
Q
R
L
V
E
E
R
Y
S
W
T
S
Q
L
S
Site 11
S234
R
L
V
E
E
R
Y
S
W
T
S
Q
L
S
P
Site 12
T236
V
E
E
R
Y
S
W
T
S
Q
L
S
P
A
D
Site 13
S237
E
E
R
Y
S
W
T
S
Q
L
S
P
A
D
L
Site 14
S240
Y
S
W
T
S
Q
L
S
P
A
D
L
I
P
L
Site 15
S255
E
V
P
T
G
A
S
S
P
T
Q
R
D
W
Q
Site 16
T257
P
T
G
A
S
S
P
T
Q
R
D
W
Q
E
Q
Site 17
Y282
R
A
H
I
R
E
Q
Y
L
I
Q
G
S
R
M
Site 18
S287
E
Q
Y
L
I
Q
G
S
R
M
R
F
L
D
T
Site 19
S310
G
L
S
S
F
Q
R
S
L
W
I
A
A
K
Q
Site 20
S332
P
T
K
Q
G
Q
K
S
Q
R
K
A
R
R
G
Site 21
S343
A
R
R
G
P
A
I
S
S
W
D
W
L
D
I
Site 22
S351
S
W
D
W
L
D
I
S
S
V
N
S
L
A
E
Site 23
S433
G
M
L
E
M
G
V
S
Y
L
P
V
N
Q
N
Site 24
Y434
M
L
E
M
G
V
S
Y
L
P
V
N
Q
N
W
Site 25
S462
L
Q
R
E
M
K
K
S
L
M
D
L
A
N
D
Site 26
Y479
Q
L
L
S
G
E
R
Y
K
E
D
P
W
L
W
Site 27
T509
K
V
K
K
E
P
A
T
A
S
K
L
P
I
E
Site 28
S534
Q
E
D
L
G
P
C
S
E
E
E
E
F
Q
Q
Site 29
T586
R
L
D
D
P
A
W
T
P
G
P
S
L
L
S
Site 30
S590
P
A
W
T
P
G
P
S
L
L
S
L
Q
M
R
Site 31
S593
T
P
G
P
S
L
L
S
L
Q
M
R
V
T
P
Site 32
Y614
W
D
G
F
P
L
H
Y
S
E
R
H
G
W
G
Site 33
Y622
S
E
R
H
G
W
G
Y
L
V
P
G
R
R
D
Site 34
S685
E
F
L
L
T
D
N
S
A
I
W
Q
T
V
E
Site 35
T690
D
N
S
A
I
W
Q
T
V
E
E
L
D
Y
L
Site 36
Y696
Q
T
V
E
E
L
D
Y
L
E
V
E
A
E
A
Site 37
T720
P
G
Q
P
L
A
L
T
A
R
G
G
P
K
D
Site 38
T728
A
R
G
G
P
K
D
T
Q
P
S
Y
H
H
G
Site 39
S731
G
P
K
D
T
Q
P
S
Y
H
H
G
N
G
P
Site 40
Y732
P
K
D
T
Q
P
S
Y
H
H
G
N
G
P
Y
Site 41
S759
L
P
H
K
D
G
N
S
C
N
V
G
S
P
F
Site 42
S764
G
N
S
C
N
V
G
S
P
F
A
K
D
F
L
Site 43
T778
L
P
K
M
E
D
G
T
L
Q
A
G
P
G
G
Site 44
S809
R
N
A
H
K
R
I
S
S
Q
M
V
V
W
L
Site 45
S810
N
A
H
K
R
I
S
S
Q
M
V
V
W
L
P
Site 46
Y831
A
V
I
R
H
P
D
Y
D
E
E
G
L
Y
G
Site 47
Y837
D
Y
D
E
E
G
L
Y
G
A
I
L
P
Q
V
Site 48
T858
T
R
R
A
V
E
P
T
W
L
T
A
S
N
A
Site 49
S863
E
P
T
W
L
T
A
S
N
A
R
P
D
R
V
Site 50
S872
A
R
P
D
R
V
G
S
E
L
K
A
M
V
Q
Site 51
S926
M
T
L
Q
G
R
K
S
R
G
T
D
L
H
S
Site 52
T929
Q
G
R
K
S
R
G
T
D
L
H
S
K
T
A
Site 53
S933
S
R
G
T
D
L
H
S
K
T
A
T
T
V
G
Site 54
T935
G
T
D
L
H
S
K
T
A
T
T
V
G
I
S
Site 55
T937
D
L
H
S
K
T
A
T
T
V
G
I
S
R
E
Site 56
Y951
E
H
A
K
I
F
N
Y
G
R
I
Y
G
A
G
Site 57
Y955
I
F
N
Y
G
R
I
Y
G
A
G
Q
P
F
A
Site 58
T974
M
Q
F
N
H
R
L
T
Q
Q
E
A
A
E
K
Site 59
Y986
A
E
K
A
Q
Q
M
Y
A
A
T
K
G
L
R
Site 60
Y995
A
T
K
G
L
R
W
Y
R
L
S
D
E
G
E
Site 61
S998
G
L
R
W
Y
R
L
S
D
E
G
E
W
L
V
Site 62
T1015
L
N
L
P
V
D
R
T
E
G
G
W
I
S
L
Site 63
S1021
R
T
E
G
G
W
I
S
L
Q
D
L
R
K
V
Site 64
T1032
L
R
K
V
Q
R
E
T
A
R
K
S
Q
W
K
Site 65
S1036
Q
R
E
T
A
R
K
S
Q
W
K
K
W
E
V
Site 66
S1055
A
W
K
G
G
T
E
S
E
M
F
N
K
L
E
Site 67
S1063
E
M
F
N
K
L
E
S
I
A
T
S
D
I
P
Site 68
S1067
K
L
E
S
I
A
T
S
D
I
P
R
T
P
V
Site 69
S1086
I
S
R
A
L
E
P
S
A
V
Q
E
E
F
M
Site 70
Y1139
S
I
H
D
E
V
R
Y
L
V
R
E
E
D
R
Site 71
Y1147
L
V
R
E
E
D
R
Y
R
A
A
L
A
L
Q
Site 72
T1194
R
C
L
R
K
E
V
T
M
D
C
K
T
P
S
Site 73
T1199
E
V
T
M
D
C
K
T
P
S
N
P
T
G
M
Site 74
S1201
T
M
D
C
K
T
P
S
N
P
T
G
M
E
R
Site 75
Y1210
P
T
G
M
E
R
R
Y
G
I
P
Q
G
E
A
Site 76
Y1221
Q
G
E
A
L
D
I
Y
Q
I
I
E
L
T
K
Site 77
S1230
I
I
E
L
T
K
G
S
L
E
K
R
S
Q
P
Site 78
S1235
K
G
S
L
E
K
R
S
Q
P
G
P
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation