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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ICLN
Full Name:
Methylosome subunit pICln
Alias:
Chloride channel, nucleotide sensitive 1A; Chloride channel, nucleotide-sensitive, 1A; Chloride conductance regulatory protein ICln; Chloride ion current inducer protein; ClCI; CLCNI; CLNS1A; I(Cln); Methylosome subunit pICln: Chloride conductance regulatory protein ICln: Chloride channel, nucleotide sensitive 1A: Chloride ion current inducer protein: Reticulocyte pICln; RCL1; Reticulocyte pICln
Type:
Channel, chloride
Mass (Da):
26215
Number AA:
237
UniProt ID:
P54105
International Prot ID:
IPI00004795
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005856
GO:0005634
GO:0005886
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
GO:0008015
GO:0006884
GO:0006821
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S2
_
_
_
_
_
_
M
S
F
L
K
S
F
P
P
Site 2
S6
_
_
M
S
F
L
K
S
F
P
P
P
G
P
A
Site 3
T23
L
L
R
Q
Q
P
D
T
E
A
V
L
N
G
K
Site 4
T36
G
K
G
L
G
T
G
T
L
Y
I
A
E
S
R
Site 5
S42
G
T
L
Y
I
A
E
S
R
L
S
W
L
D
G
Site 6
S45
Y
I
A
E
S
R
L
S
W
L
D
G
S
G
L
Site 7
S50
R
L
S
W
L
D
G
S
G
L
G
F
S
L
E
Site 8
S55
D
G
S
G
L
G
F
S
L
E
Y
P
T
I
S
Site 9
S62
S
L
E
Y
P
T
I
S
L
H
A
L
S
R
D
Site 10
S67
T
I
S
L
H
A
L
S
R
D
R
S
D
C
L
Site 11
S71
H
A
L
S
R
D
R
S
D
C
L
G
E
H
L
Site 12
S90
N
A
K
F
E
E
E
S
K
E
P
V
A
D
E
Site 13
S102
A
D
E
E
E
E
D
S
D
D
D
V
E
P
I
Site 14
T110
D
D
D
V
E
P
I
T
E
F
R
F
V
P
S
Site 15
S117
T
E
F
R
F
V
P
S
D
K
S
A
L
E
A
Site 16
S120
R
F
V
P
S
D
K
S
A
L
E
A
M
F
T
Site 17
S144
P
D
P
E
D
E
D
S
D
D
Y
D
G
E
E
Site 18
Y147
E
D
E
D
S
D
D
Y
D
G
E
E
Y
D
V
Site 19
Y152
D
D
Y
D
G
E
E
Y
D
V
E
A
H
E
Q
Site 20
T166
Q
G
Q
G
D
I
P
T
F
Y
T
Y
E
E
G
Site 21
Y168
Q
G
D
I
P
T
F
Y
T
Y
E
E
G
L
S
Site 22
T169
G
D
I
P
T
F
Y
T
Y
E
E
G
L
S
H
Site 23
Y170
D
I
P
T
F
Y
T
Y
E
E
G
L
S
H
L
Site 24
S175
Y
T
Y
E
E
G
L
S
H
L
T
A
E
G
Q
Site 25
T184
L
T
A
E
G
Q
A
T
L
E
R
L
E
G
M
Site 26
S193
E
R
L
E
G
M
L
S
Q
S
V
S
S
Q
Y
Site 27
S195
L
E
G
M
L
S
Q
S
V
S
S
Q
Y
N
M
Site 28
S197
G
M
L
S
Q
S
V
S
S
Q
Y
N
M
A
G
Site 29
S198
M
L
S
Q
S
V
S
S
Q
Y
N
M
A
G
V
Site 30
Y200
S
Q
S
V
S
S
Q
Y
N
M
A
G
V
R
T
Site 31
T207
Y
N
M
A
G
V
R
T
E
D
S
I
R
D
Y
Site 32
S210
A
G
V
R
T
E
D
S
I
R
D
Y
E
D
G
Site 33
Y214
T
E
D
S
I
R
D
Y
E
D
G
M
E
V
D
Site 34
T223
D
G
M
E
V
D
T
T
P
T
V
A
G
Q
F
Site 35
T225
M
E
V
D
T
T
P
T
V
A
G
Q
F
E
D
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation