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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
HIRA
Full Name:
Protein HIRA
Alias:
DGCR1; DiGeorge critical region gene 1; HIR histone cell cycle regulation defective A; TUP1; TUP1 like enhancer of split protein 1; TUP1-like enhancer of split protein 1; TUPLE1
Type:
Cell cycle regulation
Mass (Da):
111835
Number AA:
1017
UniProt ID:
P54198
International Prot ID:
IPI00217560
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
GO:0043226
GO:0043227
Uniprot
OncoNet
Molecular Function:
GO:0003682
GO:0003714
GO:0003700
PhosphoSite+
KinaseNET
Biological Process:
GO:0016568
GO:0006357
GO:0006350
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T26
V
D
I
H
P
D
G
T
K
F
A
T
G
G
Q
Site 2
S37
T
G
G
Q
G
Q
D
S
G
K
V
V
I
W
N
Site 3
S46
K
V
V
I
W
N
M
S
P
V
L
Q
E
D
D
Site 4
Y84
R
W
S
N
S
G
M
Y
L
A
S
G
G
D
D
Site 5
S106
R
A
T
Y
I
G
P
S
T
V
F
G
S
S
G
Site 6
T107
A
T
Y
I
G
P
S
T
V
F
G
S
S
G
K
Site 7
T181
S
G
L
V
K
G
L
T
W
D
P
V
G
K
Y
Site 8
Y188
T
W
D
P
V
G
K
Y
I
A
S
Q
A
D
D
Site 9
S191
P
V
G
K
Y
I
A
S
Q
A
D
D
R
S
L
Site 10
S197
A
S
Q
A
D
D
R
S
L
K
V
W
R
T
L
Site 11
T203
R
S
L
K
V
W
R
T
L
D
W
Q
L
E
T
Site 12
T213
W
Q
L
E
T
S
I
T
K
P
F
D
E
C
G
Site 13
T222
P
F
D
E
C
G
G
T
T
H
V
L
R
L
S
Site 14
S229
T
T
H
V
L
R
L
S
W
S
P
D
G
H
Y
Site 15
S231
H
V
L
R
L
S
W
S
P
D
G
H
Y
L
V
Site 16
Y236
S
W
S
P
D
G
H
Y
L
V
S
A
H
A
M
Site 17
T272
V
G
H
R
K
A
V
T
V
V
K
F
N
P
K
Site 18
S289
K
K
K
Q
K
N
G
S
S
A
K
P
S
C
P
Site 19
S290
K
K
Q
K
N
G
S
S
A
K
P
S
C
P
Y
Site 20
S310
G
S
K
D
R
S
L
S
V
W
L
T
C
L
K
Site 21
S335
D
K
S
I
M
D
I
S
W
T
L
N
G
L
G
Site 22
S358
S
V
A
F
L
D
F
S
Q
D
E
L
G
D
P
Site 23
S367
D
E
L
G
D
P
L
S
E
E
E
K
S
R
I
Site 24
S372
P
L
S
E
E
E
K
S
R
I
H
Q
S
T
Y
Site 25
S377
E
K
S
R
I
H
Q
S
T
Y
G
K
S
L
A
Site 26
T378
K
S
R
I
H
Q
S
T
Y
G
K
S
L
A
I
Site 27
Y379
S
R
I
H
Q
S
T
Y
G
K
S
L
A
I
M
Site 28
S382
H
Q
S
T
Y
G
K
S
L
A
I
M
T
E
A
Site 29
T393
M
T
E
A
Q
L
S
T
A
V
I
E
N
P
E
Site 30
Y404
E
N
P
E
M
L
K
Y
Q
R
R
Q
Q
Q
Q
Site 31
S417
Q
Q
Q
L
D
Q
K
S
A
A
T
R
E
M
G
Site 32
S437
A
G
V
V
N
G
E
S
L
E
D
I
R
K
N
Site 33
T462
A
D
G
R
R
R
I
T
P
L
C
I
A
Q
L
Site 34
S475
Q
L
D
T
G
D
F
S
T
A
F
F
N
S
I
Site 35
S494
S
L
A
G
T
M
L
S
S
H
S
S
P
Q
L
Site 36
S497
G
T
M
L
S
S
H
S
S
P
Q
L
L
P
L
Site 37
S498
T
M
L
S
S
H
S
S
P
Q
L
L
P
L
D
Site 38
S506
P
Q
L
L
P
L
D
S
S
T
P
N
S
F
G
Site 39
S507
Q
L
L
P
L
D
S
S
T
P
N
S
F
G
A
Site 40
T508
L
L
P
L
D
S
S
T
P
N
S
F
G
A
S
Site 41
S511
L
D
S
S
T
P
N
S
F
G
A
S
K
P
C
Site 42
S515
T
P
N
S
F
G
A
S
K
P
C
T
E
P
V
Site 43
S526
T
E
P
V
V
A
A
S
A
R
P
A
G
D
S
Site 44
S533
S
A
R
P
A
G
D
S
V
N
K
D
S
M
N
Site 45
S538
G
D
S
V
N
K
D
S
M
N
A
T
S
T
P
Site 46
T542
N
K
D
S
M
N
A
T
S
T
P
A
A
L
S
Site 47
S543
K
D
S
M
N
A
T
S
T
P
A
A
L
S
P
Site 48
T544
D
S
M
N
A
T
S
T
P
A
A
L
S
P
S
Site 49
S549
T
S
T
P
A
A
L
S
P
S
V
L
T
T
P
Site 50
S551
T
P
A
A
L
S
P
S
V
L
T
T
P
S
K
Site 51
T554
A
L
S
P
S
V
L
T
T
P
S
K
I
E
P
Site 52
T555
L
S
P
S
V
L
T
T
P
S
K
I
E
P
M
Site 53
S557
P
S
V
L
T
T
P
S
K
I
E
P
M
K
A
Site 54
S567
E
P
M
K
A
F
D
S
R
F
T
E
R
S
K
Site 55
T570
K
A
F
D
S
R
F
T
E
R
S
K
A
T
P
Site 56
S573
D
S
R
F
T
E
R
S
K
A
T
P
G
A
P
Site 57
T576
F
T
E
R
S
K
A
T
P
G
A
P
A
L
T
Site 58
T583
T
P
G
A
P
A
L
T
S
M
T
P
T
A
V
Site 59
S584
P
G
A
P
A
L
T
T
M
T
P
T
A
V
E
Site 60
T586
A
P
A
L
T
S
M
T
P
T
A
V
E
R
L
Site 61
T588
A
L
T
S
M
T
P
T
A
V
E
R
L
K
E
Site 62
S610
R
P
R
D
L
L
E
S
S
S
D
S
D
E
K
Site 63
S611
P
R
D
L
L
E
S
S
S
D
S
D
E
K
V
Site 64
S612
R
D
L
L
E
S
S
S
D
S
D
E
K
V
P
Site 65
S614
L
L
E
S
S
S
D
S
D
E
K
V
P
L
A
Site 66
S625
V
P
L
A
K
A
S
S
L
S
K
R
K
L
E
Site 67
S627
L
A
K
A
S
S
L
S
K
R
K
L
E
L
E
Site 68
S650
K
G
R
P
R
K
D
S
R
L
M
P
V
S
L
Site 69
S656
D
S
R
L
M
P
V
S
L
S
V
Q
S
P
A
Site 70
S661
P
V
S
L
S
V
Q
T
P
A
A
L
T
A
E
Site 71
S687
A
L
K
L
P
I
P
S
P
Q
R
A
F
T
L
Site 72
T693
P
S
P
Q
R
A
F
T
L
Q
V
S
S
D
P
Site 73
S697
R
A
F
T
L
Q
V
S
S
D
P
S
M
Y
I
Site 74
S698
A
F
T
L
Q
V
S
S
D
P
S
M
Y
I
E
Site 75
S701
L
Q
V
S
S
D
P
S
M
Y
I
E
V
E
N
Site 76
Y703
V
S
S
D
P
S
M
Y
I
E
V
E
N
E
V
Site 77
T711
I
E
V
E
N
E
V
T
V
V
G
G
V
K
L
Site 78
T732
R
E
G
K
E
W
E
T
V
L
T
S
R
I
L
Site 79
T735
K
E
W
E
T
V
L
T
S
R
I
L
T
A
A
Site 80
S758
A
C
E
K
R
M
L
S
V
F
S
T
C
G
R
Site 81
S815
V
K
E
E
S
L
H
S
I
L
A
G
S
D
M
Site 82
S863
L
V
S
D
K
Q
D
S
L
A
Q
C
A
D
F
Site 83
S872
A
Q
C
A
D
F
R
S
S
L
P
S
Q
D
A
Site 84
S873
Q
C
A
D
F
R
S
S
L
P
S
Q
D
A
M
Site 85
S876
D
F
R
S
S
L
P
S
Q
D
A
M
L
C
S
Site 86
S894
A
I
I
Q
G
R
T
S
N
S
G
R
Q
A
A
Site 87
S896
I
Q
G
R
T
S
N
S
G
R
Q
A
A
R
L
Site 88
S905
R
Q
A
A
R
L
F
S
V
P
H
V
V
Q
Q
Site 89
T928
N
Q
V
A
A
A
L
T
L
Q
S
S
H
E
Y
Site 90
S932
A
A
L
T
L
Q
S
S
H
E
Y
R
H
W
L
Site 91
Y935
T
L
Q
S
S
H
E
Y
R
H
W
L
L
V
Y
Site 92
Y942
Y
R
H
W
L
L
V
Y
A
R
Y
L
V
N
E
Site 93
Y945
W
L
L
V
Y
A
R
Y
L
V
N
E
G
F
E
Site 94
Y953
L
V
N
E
G
F
E
Y
R
L
R
E
I
C
K
Site 95
Y968
D
L
L
G
P
V
H
Y
S
T
G
S
Q
W
E
Site 96
S969
L
L
G
P
V
H
Y
S
T
G
S
Q
W
E
S
Site 97
T970
L
G
P
V
H
Y
S
T
G
S
Q
W
E
S
T
Site 98
S972
P
V
H
Y
S
T
G
S
Q
W
E
S
T
V
V
Site 99
S976
S
T
G
S
Q
W
E
S
T
V
V
G
L
R
K
Site 100
T977
T
G
S
Q
W
E
S
T
V
V
G
L
R
K
R
Site 101
T1005
L
R
F
Q
R
L
F
T
E
C
Q
E
Q
L
D
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation