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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ATXN1
Full Name:
Ataxin-1
Alias:
Ataxin 1; ATX1; D6S504E; SCA1; Spinocerebellar ataxia type 1 protein; Spinocerebellar ataxia type 1 protein homolog
Type:
RNA binding protein
Mass (Da):
86923
Number AA:
815
UniProt ID:
P54253
International Prot ID:
IPI00432008
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0042405
GO:0016363
Uniprot
OncoNet
Molecular Function:
GO:0042802
GO:0034046
GO:0008266
PhosphoSite+
KinaseNET
Biological Process:
GO:0006396
GO:0008219
GO:0016481
Phosida
TranscriptoNet
STRING
Kinexus Products
Ataxin-1 pan-specific antibody AB-NN205-1#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-NN205-1#Spinocerebellar ataxia type 1 protein pan-specific antibody AB-NN205-2#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-NN205-2
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T22
K
K
R
E
I
P
A
T
S
R
S
S
E
E
K
Site 2
S23
K
R
E
I
P
A
T
S
R
S
S
E
E
K
A
Site 3
S25
E
I
P
A
T
S
R
S
S
E
E
K
A
P
T
Site 4
S26
I
P
A
T
S
R
S
S
E
E
K
A
P
T
L
Site 5
T32
S
S
E
E
K
A
P
T
L
P
S
D
N
H
R
Site 6
S35
E
K
A
P
T
L
P
S
D
N
H
R
V
E
G
Site 7
S82
I
G
L
H
K
A
L
S
T
G
L
D
Y
S
P
Site 8
Y87
A
L
S
T
G
L
D
Y
S
P
P
S
A
P
R
Site 9
S88
L
S
T
G
L
D
Y
S
P
P
S
A
P
R
S
Site 10
S91
G
L
D
Y
S
P
P
S
A
P
R
S
V
P
V
Site 11
S95
S
P
P
S
A
P
R
S
V
P
V
A
T
T
L
Site 12
Y106
A
T
T
L
P
A
A
Y
A
T
P
Q
P
G
T
Site 13
T108
T
L
P
A
A
Y
A
T
P
Q
P
G
T
P
V
Site 14
T113
Y
A
T
P
Q
P
G
T
P
V
S
P
V
Q
Y
Site 15
S116
P
Q
P
G
T
P
V
S
P
V
Q
Y
A
H
L
Site 16
Y120
T
P
V
S
P
V
Q
Y
A
H
L
P
H
T
F
Site 17
T126
Q
Y
A
H
L
P
H
T
F
Q
F
I
G
S
S
Site 18
S133
T
F
Q
F
I
G
S
S
Q
Y
S
G
T
Y
A
Site 19
T138
G
S
S
Q
Y
S
G
T
Y
A
S
F
I
P
S
Site 20
Y139
S
S
Q
Y
S
G
T
Y
A
S
F
I
P
S
Q
Site 21
S141
Q
Y
S
G
T
Y
A
S
F
I
P
S
Q
L
I
Site 22
T151
P
S
Q
L
I
P
P
T
A
N
P
V
T
S
A
Site 23
T167
A
S
A
A
G
A
T
T
P
S
Q
R
S
Q
L
Site 24
S169
A
A
G
A
T
T
P
S
Q
R
S
Q
L
E
A
Site 25
T179
S
Q
L
E
A
Y
S
T
L
L
A
N
M
G
S
Site 26
S186
T
L
L
A
N
M
G
S
L
S
Q
T
P
G
H
Site 27
S188
L
A
N
M
G
S
L
S
Q
T
P
G
H
K
A
Site 28
T190
N
M
G
S
L
S
Q
T
P
G
H
K
A
E
Q
Site 29
S228
Q
Q
Q
Q
Q
H
L
S
R
A
P
G
L
I
T
Site 30
T235
S
R
A
P
G
L
I
T
P
G
S
P
P
P
A
Site 31
S238
P
G
L
I
T
P
G
S
P
P
P
A
Q
Q
N
Site 32
Y247
P
P
A
Q
Q
N
Q
Y
V
H
I
S
S
S
P
Site 33
S252
N
Q
Y
V
H
I
S
S
S
P
Q
N
T
G
R
Site 34
S253
Q
Y
V
H
I
S
S
S
P
Q
N
T
G
R
T
Site 35
T257
I
S
S
S
P
Q
N
T
G
R
T
A
S
P
P
Site 36
T260
S
P
Q
N
T
G
R
T
A
S
P
P
A
I
P
Site 37
S262
Q
N
T
G
R
T
A
S
P
P
A
I
P
V
H
Site 38
T280
H
Q
T
M
I
P
H
T
L
T
L
G
P
P
S
Site 39
Y293
P
S
Q
V
V
M
Q
Y
A
D
S
G
S
H
F
Site 40
S296
V
V
M
Q
Y
A
D
S
G
S
H
F
V
P
R
Site 41
S298
M
Q
Y
A
D
S
G
S
H
F
V
P
R
E
A
Site 42
T306
H
F
V
P
R
E
A
T
K
K
A
E
S
S
R
Site 43
S311
E
A
T
K
K
A
E
S
S
R
L
Q
Q
A
I
Site 44
S331
L
N
G
E
M
E
K
S
R
R
Y
G
A
P
S
Site 45
Y334
E
M
E
K
S
R
R
Y
G
A
P
S
S
A
D
Site 46
S338
S
R
R
Y
G
A
P
S
S
A
D
L
G
L
G
Site 47
S339
R
R
Y
G
A
P
S
S
A
D
L
G
L
G
K
Site 48
S351
L
G
K
A
G
G
K
S
V
P
H
P
Y
E
S
Site 49
Y356
G
K
S
V
P
H
P
Y
E
S
R
H
V
V
V
Site 50
S358
S
V
P
H
P
Y
E
S
R
H
V
V
V
H
P
Site 51
S366
R
H
V
V
V
H
P
S
P
S
D
Y
S
S
R
Site 52
S368
V
V
V
H
P
S
P
S
D
Y
S
S
R
D
P
Site 53
Y370
V
H
P
S
P
S
D
Y
S
S
R
D
P
S
G
Site 54
S371
H
P
S
P
S
D
Y
S
S
R
D
P
S
G
V
Site 55
S372
P
S
P
S
D
Y
S
S
R
D
P
S
G
V
R
Site 56
S376
D
Y
S
S
R
D
P
S
G
V
R
A
S
V
M
Site 57
S381
D
P
S
G
V
R
A
S
V
M
V
L
P
N
S
Site 58
S406
Q
A
T
H
R
E
A
S
P
S
T
L
N
D
K
Site 59
S408
T
H
R
E
A
S
P
S
T
L
N
D
K
S
G
Site 60
T409
H
R
E
A
S
P
S
T
L
N
D
K
S
G
L
Site 61
S414
P
S
T
L
N
D
K
S
G
L
H
L
G
K
P
Site 62
S425
L
G
K
P
G
H
R
S
Y
A
L
S
P
H
T
Site 63
Y426
G
K
P
G
H
R
S
Y
A
L
S
P
H
T
V
Site 64
S429
G
H
R
S
Y
A
L
S
P
H
T
V
I
Q
T
Site 65
T432
S
Y
A
L
S
P
H
T
V
I
Q
T
T
H
S
Site 66
T437
P
H
T
V
I
Q
T
T
H
S
A
S
E
P
L
Site 67
S439
T
V
I
Q
T
T
H
S
A
S
E
P
L
P
V
Site 68
Y464
T
Q
P
P
V
I
G
Y
L
S
G
Q
Q
Q
A
Site 69
T473
S
G
Q
Q
Q
A
I
T
Y
A
G
S
L
P
Q
Site 70
S530
V
T
T
A
L
P
K
S
E
N
F
N
P
E
A
Site 71
T569
S
P
A
A
A
P
P
T
L
P
P
Y
F
M
K
Site 72
T595
K
K
V
E
D
L
K
T
E
D
F
I
Q
S
A
Site 73
S605
F
I
Q
S
A
E
I
S
N
D
L
K
I
D
S
Site 74
S612
S
N
D
L
K
I
D
S
S
T
V
E
R
I
E
Site 75
S613
N
D
L
K
I
D
S
S
T
V
E
R
I
E
D
Site 76
T614
D
L
K
I
D
S
S
T
V
E
R
I
E
D
S
Site 77
S621
T
V
E
R
I
E
D
S
H
S
P
G
V
A
V
Site 78
S623
E
R
I
E
D
S
H
S
P
G
V
A
V
I
Q
Site 79
S641
G
E
H
R
A
Q
V
S
V
E
V
L
V
E
Y
Site 80
S666
S
C
C
P
E
R
T
S
Q
L
F
D
L
P
C
Site 81
S705
G
Q
P
V
D
P
A
S
V
L
L
K
H
S
K
Site 82
S719
K
A
D
G
L
A
G
S
R
H
R
Y
A
E
Q
Site 83
Y723
L
A
G
S
R
H
R
Y
A
E
Q
E
N
G
I
Site 84
S775
A
T
R
K
R
R
W
S
A
P
E
S
R
K
L
Site 85
S779
R
R
W
S
A
P
E
S
R
K
L
E
K
S
E
Site 86
S785
E
S
R
K
L
E
K
S
E
D
E
P
P
L
T
Site 87
T792
S
E
D
E
P
P
L
T
L
P
K
P
S
L
I
Site 88
S797
P
L
T
L
P
K
P
S
L
I
P
Q
E
V
K
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation