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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
HAP1
Full Name:
Huntingtin-associated protein 1
Alias:
HAP-1; HAP2; HIP5; HLP; HLP1; Huntingtin-associated 1; Neuroan 1
Type:
Cytoskeletal protein
Mass (Da):
75514
Number AA:
671
UniProt ID:
P54257
International Prot ID:
IPI00302434
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0015629
Uniprot
OncoNet
Molecular Function:
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0007420
GO:0007268
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S13
L
G
R
C
C
A
G
S
R
L
G
P
G
D
P
Site 2
T24
P
G
D
P
A
A
L
T
C
A
P
S
P
S
A
Site 3
S30
L
T
C
A
P
S
P
S
A
S
P
A
P
E
P
Site 4
S32
C
A
P
S
P
S
A
S
P
A
P
E
P
S
A
Site 5
S38
A
S
P
A
P
E
P
S
A
Q
P
Q
A
R
G
Site 6
T46
A
Q
P
Q
A
R
G
T
G
Q
R
V
G
S
R
Site 7
S52
G
T
G
Q
R
V
G
S
R
A
T
S
G
T
Q
Site 8
T55
Q
R
V
G
S
R
A
T
S
G
T
Q
F
L
S
Site 9
S56
R
V
G
S
R
A
T
S
G
T
Q
F
L
S
E
Site 10
T58
G
S
R
A
T
S
G
T
Q
F
L
S
E
A
R
Site 11
S62
T
S
G
T
Q
F
L
S
E
A
R
T
G
A
R
Site 12
T66
Q
F
L
S
E
A
R
T
G
A
R
P
A
S
E
Site 13
S72
R
T
G
A
R
P
A
S
E
A
G
A
K
A
G
Site 14
S84
K
A
G
A
R
R
P
S
A
F
S
A
I
Q
G
Site 15
S87
A
R
R
P
S
A
F
S
A
I
Q
G
D
V
R
Site 16
S95
A
I
Q
G
D
V
R
S
M
P
D
N
S
D
A
Site 17
S100
V
R
S
M
P
D
N
S
D
A
P
W
T
R
F
Site 18
T118
G
P
F
G
S
R
A
T
G
R
G
T
G
K
A
Site 19
T122
S
R
A
T
G
R
G
T
G
K
A
A
G
I
W
Site 20
T131
K
A
A
G
I
W
K
T
P
A
A
Y
V
G
R
Site 21
Y135
I
W
K
T
P
A
A
Y
V
G
R
R
P
G
V
Site 22
S143
V
G
R
R
P
G
V
S
G
P
E
R
A
A
F
Site 23
Y194
P
V
W
E
S
V
T
Y
G
M
V
L
Q
R
E
Site 24
T206
Q
R
E
R
D
L
N
T
A
A
R
I
G
Q
S
Site 25
S219
Q
S
L
V
K
Q
N
S
V
L
M
E
E
N
S
Site 26
Y241
S
A
K
E
E
I
L
Y
L
R
H
Q
V
N
L
Site 27
Y256
R
D
E
L
L
Q
L
Y
S
D
S
D
E
E
D
Site 28
S257
D
E
L
L
Q
L
Y
S
D
S
D
E
E
D
E
Site 29
S259
L
L
Q
L
Y
S
D
S
D
E
E
D
E
D
E
Site 30
S301
C
D
A
P
K
L
I
S
Q
E
A
L
L
H
Q
Site 31
S336
H
Q
L
R
E
E
A
S
Q
L
D
T
L
E
D
Site 32
T340
E
E
A
S
Q
L
D
T
L
E
D
E
E
Q
M
Site 33
Y377
L
V
L
R
L
E
N
Y
E
R
Q
Q
Q
E
V
Site 34
Y401
L
Q
Q
R
C
R
M
Y
G
A
E
T
E
K
L
Site 35
S426
Q
M
Q
L
Q
E
E
S
V
W
V
G
S
Q
L
Site 36
Y440
L
Q
D
L
R
E
K
Y
M
D
C
G
G
M
L
Site 37
T456
E
M
Q
E
E
V
K
T
L
R
Q
Q
P
P
V
Site 38
S464
L
R
Q
Q
P
P
V
S
T
G
S
A
T
H
Y
Site 39
S467
Q
P
P
V
S
T
G
S
A
T
H
Y
P
Y
S
Site 40
T469
P
V
S
T
G
S
A
T
H
Y
P
Y
S
V
P
Site 41
Y471
S
T
G
S
A
T
H
Y
P
Y
S
V
P
L
E
Site 42
Y473
G
S
A
T
H
Y
P
Y
S
V
P
L
E
T
L
Site 43
S474
S
A
T
H
Y
P
Y
S
V
P
L
E
T
L
P
Site 44
T479
P
Y
S
V
P
L
E
T
L
P
G
F
Q
E
T
Site 45
T493
T
L
A
E
E
L
R
T
S
L
R
R
M
I
S
Site 46
S494
L
A
E
E
L
R
T
S
L
R
R
M
I
S
D
Site 47
S500
T
S
L
R
R
M
I
S
D
P
V
Y
F
M
E
Site 48
Y504
R
M
I
S
D
P
V
Y
F
M
E
R
N
Y
E
Site 49
Y510
V
Y
F
M
E
R
N
Y
E
M
P
R
G
D
T
Site 50
T517
Y
E
M
P
R
G
D
T
S
S
L
R
Y
D
F
Site 51
S519
M
P
R
G
D
T
S
S
L
R
Y
D
F
R
Y
Site 52
Y522
G
D
T
S
S
L
R
Y
D
F
R
Y
S
E
D
Site 53
Y526
S
L
R
Y
D
F
R
Y
S
E
D
R
E
Q
V
Site 54
S527
L
R
Y
D
F
R
Y
S
E
D
R
E
Q
V
R
Site 55
T555
I
M
R
G
E
D
F
T
P
A
E
E
L
V
P
Site 56
Y626
P
S
H
L
D
M
N
Y
V
L
Q
Q
L
A
N
Site 57
Y639
A
N
W
Q
D
A
H
Y
R
R
Q
L
R
W
K
Site 58
S662
H
G
A
L
P
A
A
S
R
T
S
C
R
S
S
Site 59
T664
A
L
P
A
A
S
R
T
S
C
R
S
S
C
R
Site 60
S665
L
P
A
A
S
R
T
S
C
R
S
S
C
R
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation