KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
YARS
Full Name:
Tyrosyl-tRNA synthetase, cytoplasmic
Alias:
CMTDIC; SYYC; Tyrosine tRNA ligase 1, cytoplasmic; Tyrosyl-tRNA ligase; Tyrosyl-tRNA synthetase; TyrRS; YRS; YTS
Type:
Ligase; Apoptosis; Cytokine; EC 6.1.1.1
Mass (Da):
59012
Number AA:
527
UniProt ID:
P54577
International Prot ID:
IPI00007074
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005615
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0005153
GO:0004871
PhosphoSite+
KinaseNET
Biological Process:
GO:0006915
GO:0006437
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S6
_
_
M
G
D
A
P
S
P
E
E
K
L
H
L
Site 2
Y39
K
E
R
E
L
K
I
Y
W
G
T
A
T
T
G
Site 3
S95
E
L
L
E
L
R
V
S
Y
Y
E
N
V
I
K
Site 4
Y123
K
F
I
K
G
T
D
Y
Q
L
S
K
E
Y
T
Site 5
S126
K
G
T
D
Y
Q
L
S
K
E
Y
T
L
D
V
Site 6
T130
Y
Q
L
S
K
E
Y
T
L
D
V
Y
R
L
S
Site 7
Y134
K
E
Y
T
L
D
V
Y
R
L
S
S
V
V
T
Site 8
S137
T
L
D
V
Y
R
L
S
S
V
V
T
Q
H
D
Site 9
S138
L
D
V
Y
R
L
S
S
V
V
T
Q
H
D
S
Site 10
T141
Y
R
L
S
S
V
V
T
Q
H
D
S
K
K
A
Site 11
S145
S
V
V
T
Q
H
D
S
K
K
A
G
A
E
V
Site 12
Y176
L
Q
A
L
D
E
E
Y
L
K
V
D
A
Q
F
Site 13
T193
I
D
Q
R
K
I
F
T
F
A
E
K
Y
L
P
Site 14
Y204
K
Y
L
P
A
L
G
Y
S
K
R
V
H
L
M
Site 15
T219
N
P
M
V
P
G
L
T
G
S
K
M
S
S
S
Site 16
S221
M
V
P
G
L
T
G
S
K
M
S
S
S
E
E
Site 17
S225
L
T
G
S
K
M
S
S
S
E
E
E
S
K
I
Site 18
S226
T
G
S
K
M
S
S
S
E
E
E
S
K
I
D
Site 19
S230
M
S
S
S
E
E
E
S
K
I
D
L
L
D
R
Site 20
T290
W
G
G
N
K
T
Y
T
A
Y
V
D
L
E
K
Site 21
Y292
G
N
K
T
Y
T
A
Y
V
D
L
E
K
D
F
Site 22
S312
H
P
G
D
L
K
N
S
V
E
V
A
L
N
K
Site 23
T330
P
I
R
E
K
F
N
T
P
A
L
K
K
L
A
Site 24
S338
P
A
L
K
K
L
A
S
A
A
Y
P
D
P
S
Site 25
Y341
K
K
L
A
S
A
A
Y
P
D
P
S
K
Q
K
Site 26
S345
S
A
A
Y
P
D
P
S
K
Q
K
P
M
A
K
Site 27
S358
A
K
G
P
A
K
N
S
E
P
E
E
V
I
P
Site 28
S366
E
P
E
E
V
I
P
S
R
L
D
I
R
V
G
Site 29
T377
I
R
V
G
K
I
I
T
V
E
K
H
P
D
A
Site 30
S386
E
K
H
P
D
A
D
S
L
Y
V
E
K
I
D
Site 31
Y388
H
P
D
A
D
S
L
Y
V
E
K
I
D
V
G
Site 32
S436
Q
K
M
R
G
V
E
S
Q
G
M
L
L
C
A
Site 33
S461
P
L
D
P
P
A
G
S
A
P
G
E
H
V
F
Site 34
T512
W
K
Q
T
N
F
M
T
K
L
G
S
I
S
C
Site 35
S516
N
F
M
T
K
L
G
S
I
S
C
K
S
L
K
Site 36
S518
M
T
K
L
G
S
I
S
C
K
S
L
K
G
G
Site 37
S521
L
G
S
I
S
C
K
S
L
K
G
G
N
I
S
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation