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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ATP12A
Full Name:
Potassium-transporting ATPase alpha chain 2
Alias:
AT12A; ATP1AL1; ATPase, H+/K+ transporting, nongastric, alpha polypeptide; ATPase, Na+K+ transporting, alpha-1 polypeptide-like; Non-gastric H(+)/K(+) ATPase alpha subunit; Non-gastric H(+)/K(+) ATPase subunit alpha; Proton pump; Sodium/potassium ATPase, alpha polypeptide-like
Type:
Membrane protein, integral; Energy Metabolism - oxidative phosphorylation; Hydrolase; Transporter; EC 3.6.3.10
Mass (Da):
115511
Number AA:
1039
UniProt ID:
P54707
International Prot ID:
IPI00008161
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005889
GO:0016020
GO:0016021
Uniprot
OncoNet
Molecular Function:
GO:0000166
GO:0000287
GO:0003824
PhosphoSite+
KinaseNET
Biological Process:
GO:0006810
GO:0006811
GO:0006812
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T5
_
_
_
M
H
Q
K
T
P
E
I
Y
S
V
E
Site 2
S10
Q
K
T
P
E
I
Y
S
V
E
L
S
G
T
K
Site 3
S14
E
I
Y
S
V
E
L
S
G
T
K
D
I
V
K
Site 4
Y31
K
G
D
G
K
E
K
Y
R
G
L
K
N
N
C
Site 5
S62
H
L
D
D
H
K
L
S
N
R
E
L
E
E
K
Site 6
Y70
N
R
E
L
E
E
K
Y
G
T
D
I
I
M
G
Site 7
T72
E
L
E
E
K
Y
G
T
D
I
I
M
G
L
S
Site 8
S94
L
A
R
D
G
P
N
S
L
T
P
P
K
Q
T
Site 9
T96
R
D
G
P
N
S
L
T
P
P
K
Q
T
P
E
Site 10
T101
S
L
T
P
P
K
Q
T
P
E
I
V
K
F
L
Site 11
Y134
W
I
A
Y
G
I
Q
Y
S
S
D
K
S
A
S
Site 12
S135
I
A
Y
G
I
Q
Y
S
S
D
K
S
A
S
L
Site 13
S139
I
Q
Y
S
S
D
K
S
A
S
L
N
N
V
Y
Site 14
S141
Y
S
S
D
K
S
A
S
L
N
N
V
Y
L
G
Site 15
Y164
L
T
G
I
F
A
Y
Y
Q
E
A
K
S
T
N
Site 16
S169
A
Y
Y
Q
E
A
K
S
T
N
I
M
S
S
F
Site 17
T170
Y
Y
Q
E
A
K
S
T
N
I
M
S
S
F
N
Site 18
S175
K
S
T
N
I
M
S
S
F
N
K
M
I
P
Q
Site 19
S190
Q
A
L
V
I
R
D
S
E
K
K
T
I
P
S
Site 20
T194
I
R
D
S
E
K
K
T
I
P
S
E
Q
L
V
Site 21
S222
P
A
D
I
R
V
L
S
S
Q
G
C
R
V
D
Site 22
S223
A
D
I
R
V
L
S
S
Q
G
C
R
V
D
N
Site 23
S231
Q
G
C
R
V
D
N
S
S
L
T
G
E
S
E
Site 24
S232
G
C
R
V
D
N
S
S
L
T
G
E
S
E
P
Site 25
T234
R
V
D
N
S
S
L
T
G
E
S
E
P
Q
P
Site 26
S243
E
S
E
P
Q
P
R
S
S
E
F
T
H
E
N
Site 27
S244
S
E
P
Q
P
R
S
S
E
F
T
H
E
N
P
Site 28
T247
Q
P
R
S
S
E
F
T
H
E
N
P
L
E
T
Site 29
T297
S
G
V
G
N
E
K
T
P
I
A
I
E
I
E
Site 30
T362
V
T
V
T
L
S
L
T
A
K
R
M
A
K
K
Site 31
S390
G
S
T
S
I
I
C
S
D
K
T
G
T
L
T
Site 32
T393
S
I
I
C
S
D
K
T
G
T
L
T
Q
N
R
Site 33
T397
S
D
K
T
G
T
L
T
Q
N
R
M
T
V
A
Site 34
T417
N
Q
I
F
V
A
D
T
S
E
D
H
S
N
Q
Site 35
S418
Q
I
F
V
A
D
T
S
E
D
H
S
N
Q
V
Site 36
S422
A
D
T
S
E
D
H
S
N
Q
V
F
D
Q
S
Site 37
S429
S
N
Q
V
F
D
Q
S
S
R
T
W
A
S
L
Site 38
S430
N
Q
V
F
D
Q
S
S
R
T
W
A
S
L
S
Site 39
S435
Q
S
S
R
T
W
A
S
L
S
K
I
I
T
L
Site 40
S499
V
A
E
I
P
F
N
S
T
N
K
F
Q
L
S
Site 41
T500
A
E
I
P
F
N
S
T
N
K
F
Q
L
S
I
Site 42
S506
S
T
N
K
F
Q
L
S
I
H
E
M
D
D
P
Site 43
T535
R
I
L
E
K
C
S
T
I
M
I
N
G
E
E
Site 44
S548
E
E
H
P
L
D
K
S
T
A
K
T
F
H
T
Site 45
T552
L
D
K
S
T
A
K
T
F
H
T
A
Y
M
E
Site 46
T555
S
T
A
K
T
F
H
T
A
Y
M
E
L
G
G
Site 47
T583
P
A
D
E
F
P
E
T
Y
S
F
D
I
D
A
Site 48
S612
S
M
I
D
P
P
R
S
T
V
P
D
A
V
T
Site 49
T613
M
I
D
P
P
R
S
T
V
P
D
A
V
T
K
Site 50
T619
S
T
V
P
D
A
V
T
K
C
R
S
A
G
I
Site 51
S690
M
E
L
K
D
M
S
S
E
Q
L
D
E
I
L
Site 52
S737
T
G
D
G
V
N
D
S
P
A
L
K
K
A
D
Site 53
T790
I
F
D
N
L
K
K
T
I
A
Y
S
L
T
K
Site 54
S794
L
K
K
T
I
A
Y
S
L
T
K
N
I
A
E
Site 55
S844
L
A
Y
E
K
A
E
S
D
I
M
N
R
K
P
Site 56
T897
Q
E
G
F
L
P
R
T
L
I
N
L
R
V
E
Site 57
Y909
R
V
E
W
E
K
D
Y
V
N
D
L
K
D
S
Site 58
Y917
V
N
D
L
K
D
S
Y
G
Q
E
W
T
R
Y
Site 59
Y924
Y
G
Q
E
W
T
R
Y
Q
R
E
Y
L
E
W
Site 60
Y928
W
T
R
Y
Q
R
E
Y
L
E
W
T
G
Y
T
Site 61
T954
A
D
L
I
I
R
K
T
R
R
N
S
I
F
Q
Site 62
S958
I
R
K
T
R
R
N
S
I
F
Q
Q
G
L
F
Site 63
S985
I
I
I
G
L
I
L
S
Y
G
L
G
S
V
T
Site 64
Y1028
R
K
L
F
I
R
L
Y
P
G
S
W
W
D
K
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation