KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
AK2
Full Name:
Adenylate kinase 2, mitochondrial
Alias:
Adenylate kinase 2; ADK2; ATP-AMP transphosphorylase; KAD4
Type:
Kinase (non-protein); Nucleotide Metabolism - purine; EC 2.7.4.3
Mass (Da):
26478
Number AA:
239
UniProt ID:
P54819
International Prot ID:
IPI00215901
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005758
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0004017
GO:0019206
PhosphoSite+
KinaseNET
Biological Process:
GO:0006139
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y12
V
P
A
A
E
P
E
Y
P
K
G
I
R
A
V
Site 2
T30
P
P
G
A
G
K
G
T
Q
A
P
R
L
A
E
Site 3
S56
M
L
R
A
M
V
A
S
G
S
E
L
G
K
K
Site 4
S58
R
A
M
V
A
S
G
S
E
L
G
K
K
L
K
Site 5
T89
L
I
E
K
N
L
E
T
P
L
C
K
N
G
F
Site 6
T104
L
L
D
G
F
P
R
T
V
R
Q
A
E
M
L
Site 7
S124
K
R
K
E
K
L
D
S
V
I
E
F
S
I
P
Site 8
T140
S
L
L
I
R
R
I
T
G
R
L
I
H
P
K
Site 9
S148
G
R
L
I
H
P
K
S
G
R
S
Y
H
E
E
Site 10
Y152
H
P
K
S
G
R
S
Y
H
E
E
F
N
P
P
Site 11
T168
E
P
M
K
D
D
I
T
G
E
P
L
I
R
R
Site 12
S176
G
E
P
L
I
R
R
S
D
D
N
E
K
A
L
Site 13
Y190
L
K
I
R
L
Q
A
Y
H
T
Q
T
T
P
L
Site 14
T195
Q
A
Y
H
T
Q
T
T
P
L
I
E
Y
Y
R
Site 15
Y200
Q
T
T
P
L
I
E
Y
Y
R
K
R
G
I
H
Site 16
Y201
T
T
P
L
I
E
Y
Y
R
K
R
G
I
H
S
Site 17
S208
Y
R
K
R
G
I
H
S
A
I
D
A
S
Q
T
Site 18
T215
S
A
I
D
A
S
Q
T
P
D
V
V
F
A
S
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation