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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
STEP
Full Name:
Tyrosine-protein phosphatase non-receptor type 5
Alias:
EC 3.1.3.48; PTN5; PTPN5; STEP(46)
Type:
Protein-tyrosine phosphatase
Mass (Da):
61092
Number AA:
537
UniProt ID:
P54829
International Prot ID:
IPI00008837
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0016021
Uniprot
OncoNet
Molecular Function:
GO:0004725
PhosphoSite+
KinaseNET
Biological Process:
GO:0006470
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S8
M
N
Y
E
G
A
R
S
E
R
E
N
H
A
A
Site 2
S18
E
N
H
A
A
D
D
S
E
G
G
A
L
D
M
Site 3
S52
E
A
E
G
L
Q
D
S
Q
R
E
M
P
P
P
Site 4
S63
M
P
P
P
P
P
P
S
P
P
S
D
P
A
Q
Site 5
S66
P
P
P
P
S
P
P
S
D
P
A
Q
K
P
P
Site 6
S79
P
P
P
R
G
A
G
S
H
S
L
T
V
R
S
Site 7
S81
P
R
G
A
G
S
H
S
L
T
V
R
S
S
L
Site 8
S138
E
P
T
A
W
L
D
S
G
T
W
G
V
P
S
Site 9
T168
L
V
W
H
L
L
R
T
P
A
E
P
P
T
P
Site 10
T174
R
T
P
A
E
P
P
T
P
L
P
P
E
D
R
Site 11
S184
P
P
E
D
R
R
Q
S
V
S
R
Q
P
S
F
Site 12
S186
E
D
R
R
Q
S
V
S
R
Q
P
S
F
T
Y
Site 13
S190
Q
S
V
S
R
Q
P
S
F
T
Y
S
E
W
M
Site 14
T192
V
S
R
Q
P
S
F
T
Y
S
E
W
M
E
E
Site 15
T230
I
K
P
E
A
D
P
T
S
L
T
V
K
S
M
Site 16
S231
K
P
E
A
D
P
T
S
L
T
V
K
S
M
G
Site 17
T233
E
A
D
P
T
S
L
T
V
K
S
M
G
L
Q
Site 18
S245
G
L
Q
E
R
R
G
S
N
V
S
L
T
L
D
Site 19
S248
E
R
R
G
S
N
V
S
L
T
L
D
M
C
T
Site 20
T250
R
G
S
N
V
S
L
T
L
D
M
C
T
P
G
Site 21
T255
S
L
T
L
D
M
C
T
P
G
C
N
E
E
G
Site 22
Y265
C
N
E
E
G
F
G
Y
L
M
S
P
R
E
E
Site 23
S268
E
G
F
G
Y
L
M
S
P
R
E
E
S
A
R
Site 24
S273
L
M
S
P
R
E
E
S
A
R
E
Y
L
L
S
Site 25
Y277
R
E
E
S
A
R
E
Y
L
L
S
A
S
R
V
Site 26
S280
S
A
R
E
Y
L
L
S
A
S
R
V
L
Q
A
Site 27
Y317
N
F
V
D
P
K
E
Y
D
I
P
G
L
V
R
Site 28
T330
V
R
K
N
R
Y
K
T
I
L
P
N
P
H
S
Site 29
S337
T
I
L
P
N
P
H
S
R
V
C
L
T
S
P
Site 30
S343
H
S
R
V
C
L
T
S
P
D
P
D
D
P
L
Site 31
S351
P
D
P
D
D
P
L
S
S
Y
I
N
A
N
Y
Site 32
S352
D
P
D
D
P
L
S
S
Y
I
N
A
N
Y
I
Site 33
Y353
P
D
D
P
L
S
S
Y
I
N
A
N
Y
I
R
Site 34
Y358
S
S
Y
I
N
A
N
Y
I
R
G
Y
G
G
E
Site 35
Y362
N
A
N
Y
I
R
G
Y
G
G
E
E
K
V
Y
Site 36
Y369
Y
G
G
E
E
K
V
Y
I
A
T
Q
G
P
I
Site 37
Y419
W
P
E
E
Q
V
A
Y
D
G
V
E
I
T
V
Site 38
Y435
K
V
I
H
T
E
D
Y
R
L
R
L
I
S
L
Site 39
S441
D
Y
R
L
R
L
I
S
L
K
S
G
T
E
E
Site 40
S444
L
R
L
I
S
L
K
S
G
T
E
E
R
G
L
Site 41
T446
L
I
S
L
K
S
G
T
E
E
R
G
L
K
H
Site 42
Y454
E
E
R
G
L
K
H
Y
W
F
T
S
W
P
D
Site 43
T464
T
S
W
P
D
Q
K
T
P
D
R
A
P
P
L
Site 44
T527
G
V
V
D
I
L
K
T
T
C
Q
L
R
Q
D
Site 45
S553
Q
F
V
H
H
V
M
S
L
Y
E
K
Q
L
S
Site 46
Y555
V
H
H
V
M
S
L
Y
E
K
Q
L
S
H
Q
Site 47
S560
S
L
Y
E
K
Q
L
S
H
Q
S
P
E
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation