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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
HEM1
Full Name:
Nck-associated protein 1-like
Alias:
Hematopoietic protein 1; Membrane-associated protein HEM-1; NckAP1L; NCKPL
Type:
Unknown function
Mass (Da):
128215
Number AA:
1127
UniProt ID:
P55160
International Prot ID:
IPI00023407
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005887
GO:0005624
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y30
Q
G
V
L
I
R
M
Y
N
I
K
K
T
C
S
Site 2
T35
R
M
Y
N
I
K
K
T
C
S
D
P
K
S
K
Site 3
S37
Y
N
I
K
K
T
C
S
D
P
K
S
K
P
P
Site 4
S41
K
T
C
S
D
P
K
S
K
P
P
F
L
L
E
Site 5
S50
P
P
F
L
L
E
K
S
M
E
P
S
L
K
Y
Site 6
S54
L
E
K
S
M
E
P
S
L
K
Y
I
N
K
K
Site 7
Y57
S
M
E
P
S
L
K
Y
I
N
K
K
F
P
N
Site 8
S70
P
N
I
D
V
R
N
S
T
Q
H
L
G
P
V
Site 9
T71
N
I
D
V
R
N
S
T
Q
H
L
G
P
V
H
Site 10
Y106
M
E
F
R
D
H
V
Y
E
L
L
N
T
I
D
Site 11
S172
L
H
G
H
G
D
P
S
F
A
R
L
G
Q
M
Site 12
Y183
L
G
Q
M
V
L
E
Y
D
H
P
L
K
K
L
Site 13
T191
D
H
P
L
K
K
L
T
E
E
F
G
P
H
T
Site 14
T198
T
E
E
F
G
P
H
T
K
A
V
S
G
A
L
Site 15
S224
Q
G
A
E
Q
W
R
S
A
Q
L
L
S
L
I
Site 16
S229
W
R
S
A
Q
L
L
S
L
I
S
N
P
P
A
Site 17
S310
K
V
T
E
D
L
F
S
S
L
K
G
Y
G
K
Site 18
S311
V
T
E
D
L
F
S
S
L
K
G
Y
G
K
R
Site 19
Y315
L
F
S
S
L
K
G
Y
G
K
R
V
A
D
I
Site 20
T381
S
F
I
R
D
E
V
T
W
L
V
R
H
T
E
Site 21
T387
V
T
W
L
V
R
H
T
E
N
V
T
K
T
K
Site 22
T393
H
T
E
N
V
T
K
T
K
T
P
E
D
Y
A
Site 23
T395
E
N
V
T
K
T
K
T
P
E
D
Y
A
D
S
Site 24
Y399
K
T
K
T
P
E
D
Y
A
D
S
S
I
A
E
Site 25
S402
T
P
E
D
Y
A
D
S
S
I
A
E
L
L
F
Site 26
Y432
I
Q
Q
Y
H
L
Q
Y
L
A
R
F
D
A
L
Site 27
S449
S
D
I
I
Q
N
L
S
V
C
P
E
E
E
S
Site 28
S483
N
G
E
K
F
E
F
S
G
L
R
L
D
W
F
Site 29
Y495
D
W
F
R
L
Q
A
Y
T
S
V
A
K
A
P
Site 30
S497
F
R
L
Q
A
Y
T
S
V
A
K
A
P
L
H
Site 31
S527
F
H
S
R
M
L
D
S
V
E
K
L
L
V
E
Site 32
Y587
H
E
M
C
P
E
E
Y
P
H
L
K
N
H
G
Site 33
S600
H
G
L
H
H
C
N
S
F
L
E
E
L
A
K
Site 34
S610
E
E
L
A
K
Q
T
S
N
C
V
L
E
I
C
Site 35
S624
C
A
E
Q
R
N
L
S
E
Q
L
L
P
K
H
Site 36
T650
K
T
R
K
Q
R
Q
T
P
R
K
G
E
P
E
Site 37
S665
R
D
K
P
G
A
E
S
H
R
K
N
R
S
I
Site 38
T684
D
K
L
H
L
N
L
T
E
L
A
L
T
M
N
Site 39
S706
F
E
H
T
I
F
P
S
E
Y
L
S
S
H
L
Site 40
Y708
H
T
I
F
P
S
E
Y
L
S
S
H
L
E
A
Site 41
S710
I
F
P
S
E
Y
L
S
S
H
L
E
A
R
L
Site 42
S711
F
P
S
E
Y
L
S
S
H
L
E
A
R
L
N
Site 43
S738
T
Q
E
I
V
R
P
S
E
L
L
A
G
V
K
Site 44
Y789
E
Q
T
I
T
T
L
Y
T
N
W
Y
L
E
S
Site 45
Y793
T
T
L
Y
T
N
W
Y
L
E
S
L
L
R
Q
Site 46
S796
Y
T
N
W
Y
L
E
S
L
L
R
Q
A
S
S
Site 47
S817
P
A
M
Q
A
F
V
S
L
P
R
E
G
E
Q
Site 48
S827
R
E
G
E
Q
N
F
S
A
E
E
F
S
D
I
Site 49
S835
A
E
E
F
S
D
I
S
E
M
R
A
L
A
E
Site 50
S883
D
I
L
V
Q
I
R
S
N
F
S
K
P
D
L
Site 51
S893
S
K
P
D
L
M
A
S
L
L
P
Q
L
T
G
Site 52
T909
E
N
V
L
K
R
M
T
I
I
G
V
I
L
S
Site 53
T948
E
C
L
K
E
F
V
T
P
D
T
D
I
K
V
Site 54
T951
K
E
F
V
T
P
D
T
D
I
K
V
T
L
S
Site 55
T987
I
A
N
L
K
A
D
T
S
S
P
E
E
E
Y
Site 56
S988
A
N
L
K
A
D
T
S
S
P
E
E
E
Y
K
Site 57
S989
N
L
K
A
D
T
S
S
P
E
E
E
Y
K
V
Site 58
S1016
P
L
L
A
T
D
P
S
S
F
Y
S
I
E
K
Site 59
S1017
L
L
A
T
D
P
S
S
F
Y
S
I
E
K
D
Site 60
S1020
T
D
P
S
S
F
Y
S
I
E
K
D
G
Y
N
Site 61
Y1026
Y
S
I
E
K
D
G
Y
N
N
N
I
H
C
L
Site 62
Y1048
S
A
A
L
F
T
L
Y
N
K
N
I
E
T
H
Site 63
T1079
Q
E
T
D
K
L
K
T
R
N
R
E
S
I
S
Site 64
S1084
L
K
T
R
N
R
E
S
I
S
L
L
M
R
L
Site 65
Y1117
Y
V
L
L
R
N
A
Y
R
E
V
S
R
A
F
Site 66
S1121
R
N
A
Y
R
E
V
S
R
A
F
H
L
N
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation