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Updated November 2019
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Protein Info
Short Name:
MLLT10
Full Name:
Protein AF-10
Alias:
AF10; ALL-1 fused gene from chromosome 10; Myeloid/lymphoid or mixed-lineage leukemia (trithorax) translocated to, 10; Protein AF-10
Type:
Transcription factor
Mass (Da):
109026
Number AA:
1027
UniProt ID:
P55197
International Prot ID:
IPI00023464
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0005515
GO:0003700
GO:0008270
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S9
V
S
S
D
R
P
V
S
L
E
D
E
V
S
H
Site 2
S15
V
S
L
E
D
E
V
S
H
S
M
K
E
M
I
Site 3
S17
L
E
D
E
V
S
H
S
M
K
E
M
I
G
G
Site 4
Y41
W
A
E
N
P
L
V
Y
C
D
G
H
G
C
S
Site 5
Y138
D
R
Y
N
K
T
C
Y
I
C
D
E
Q
G
R
Site 6
S147
C
D
E
Q
G
R
E
S
K
A
A
T
G
A
C
Site 7
T151
G
R
E
S
K
A
A
T
G
A
C
M
T
C
N
Site 8
Y196
Q
Y
C
G
Y
C
K
Y
H
F
S
K
L
K
K
Site 9
S199
G
Y
C
K
Y
H
F
S
K
L
K
K
S
K
R
Site 10
S204
H
F
S
K
L
K
K
S
K
R
G
S
N
R
S
Site 11
S208
L
K
K
S
K
R
G
S
N
R
S
Y
D
Q
S
Site 12
S211
S
K
R
G
S
N
R
S
Y
D
Q
S
L
S
D
Site 13
Y212
K
R
G
S
N
R
S
Y
D
Q
S
L
S
D
S
Site 14
S215
S
N
R
S
Y
D
Q
S
L
S
D
S
S
S
H
Site 15
S217
R
S
Y
D
Q
S
L
S
D
S
S
S
H
S
Q
Site 16
S219
Y
D
Q
S
L
S
D
S
S
S
H
S
Q
D
K
Site 17
S220
D
Q
S
L
S
D
S
S
S
H
S
Q
D
K
H
Site 18
S221
Q
S
L
S
D
S
S
S
H
S
Q
D
K
H
H
Site 19
S223
L
S
D
S
S
S
H
S
Q
D
K
H
H
E
K
Site 20
Y235
H
E
K
E
K
K
K
Y
K
E
K
D
K
H
K
Site 21
S252
H
K
K
Q
P
E
P
S
P
A
L
V
P
S
L
Site 22
S258
P
S
P
A
L
V
P
S
L
T
V
T
T
E
K
Site 23
T262
L
V
P
S
L
T
V
T
T
E
K
T
Y
T
S
Site 24
T266
L
T
V
T
T
E
K
T
Y
T
S
T
S
N
N
Site 25
T268
V
T
T
E
K
T
Y
T
S
T
S
N
N
S
I
Site 26
S269
T
T
E
K
T
Y
T
S
T
S
N
N
S
I
S
Site 27
S271
E
K
T
Y
T
S
T
S
N
N
S
I
S
G
S
Site 28
S274
Y
T
S
T
S
N
N
S
I
S
G
S
L
K
R
Site 29
S276
S
T
S
N
N
S
I
S
G
S
L
K
R
L
E
Site 30
S278
S
N
N
S
I
S
G
S
L
K
R
L
E
D
T
Site 31
T285
S
L
K
R
L
E
D
T
T
A
R
F
T
N
A
Site 32
T286
L
K
R
L
E
D
T
T
A
R
F
T
N
A
N
Site 33
T290
E
D
T
T
A
R
F
T
N
A
N
F
Q
E
V
Site 34
S298
N
A
N
F
Q
E
V
S
A
H
T
S
S
G
K
Site 35
S302
Q
E
V
S
A
H
T
S
S
G
K
D
V
S
E
Site 36
S308
T
S
S
G
K
D
V
S
E
T
R
G
S
E
G
Site 37
T310
S
G
K
D
V
S
E
T
R
G
S
E
G
K
G
Site 38
S313
D
V
S
E
T
R
G
S
E
G
K
G
K
K
S
Site 39
S320
S
E
G
K
G
K
K
S
S
A
H
S
S
G
Q
Site 40
S321
E
G
K
G
K
K
S
S
A
H
S
S
G
Q
R
Site 41
S324
G
K
K
S
S
A
H
S
S
G
Q
R
G
R
K
Site 42
S325
K
K
S
S
A
H
S
S
G
Q
R
G
R
K
P
Site 43
T340
G
G
G
R
N
P
G
T
T
V
S
A
A
S
P
Site 44
T341
G
G
R
N
P
G
T
T
V
S
A
A
S
P
F
Site 45
S343
R
N
P
G
T
T
V
S
A
A
S
P
F
P
Q
Site 46
S346
G
T
T
V
S
A
A
S
P
F
P
Q
G
S
F
Site 47
S352
A
S
P
F
P
Q
G
S
F
S
G
T
P
G
S
Site 48
S354
P
F
P
Q
G
S
F
S
G
T
P
G
S
V
K
Site 49
T356
P
Q
G
S
F
S
G
T
P
G
S
V
K
S
S
Site 50
S359
S
F
S
G
T
P
G
S
V
K
S
S
S
G
S
Site 51
S362
G
T
P
G
S
V
K
S
S
S
G
S
S
V
Q
Site 52
S363
T
P
G
S
V
K
S
S
S
G
S
S
V
Q
S
Site 53
S364
P
G
S
V
K
S
S
S
G
S
S
V
Q
S
P
Site 54
S366
S
V
K
S
S
S
G
S
S
V
Q
S
P
Q
D
Site 55
S367
V
K
S
S
S
G
S
S
V
Q
S
P
Q
D
F
Site 56
S370
S
S
G
S
S
V
Q
S
P
Q
D
F
L
S
F
Site 57
S376
Q
S
P
Q
D
F
L
S
F
T
D
S
D
L
R
Site 58
T378
P
Q
D
F
L
S
F
T
D
S
D
L
R
N
D
Site 59
S380
D
F
L
S
F
T
D
S
D
L
R
N
D
S
Y
Site 60
S386
D
S
D
L
R
N
D
S
Y
S
H
S
Q
Q
S
Site 61
Y387
S
D
L
R
N
D
S
Y
S
H
S
Q
Q
S
S
Site 62
S388
D
L
R
N
D
S
Y
S
H
S
Q
Q
S
S
A
Site 63
S390
R
N
D
S
Y
S
H
S
Q
Q
S
S
A
T
K
Site 64
S394
Y
S
H
S
Q
Q
S
S
A
T
K
D
V
H
K
Site 65
S404
K
D
V
H
K
G
E
S
G
S
Q
E
G
G
V
Site 66
S406
V
H
K
G
E
S
G
S
Q
E
G
G
V
N
S
Site 67
S428
P
S
T
S
A
V
T
S
Q
P
K
S
F
E
N
Site 68
S432
A
V
T
S
Q
P
K
S
F
E
N
S
P
G
D
Site 69
S436
Q
P
K
S
F
E
N
S
P
G
D
L
G
N
S
Site 70
S443
S
P
G
D
L
G
N
S
S
L
P
T
A
G
Y
Site 71
S444
P
G
D
L
G
N
S
S
L
P
T
A
G
Y
K
Site 72
T447
L
G
N
S
S
L
P
T
A
G
Y
K
R
A
Q
Site 73
Y450
S
S
L
P
T
A
G
Y
K
R
A
Q
T
S
G
Site 74
T455
A
G
Y
K
R
A
Q
T
S
G
I
E
E
E
T
Site 75
S474
K
R
K
G
N
K
Q
S
K
H
G
P
G
R
P
Site 76
S491
N
K
N
Q
E
N
V
S
H
L
S
V
S
S
A
Site 77
S494
Q
E
N
V
S
H
L
S
V
S
S
A
S
P
T
Site 78
S496
N
V
S
H
L
S
V
S
S
A
S
P
T
S
S
Site 79
S499
H
L
S
V
S
S
A
S
P
T
S
S
V
A
S
Site 80
S503
S
S
A
S
P
T
S
S
V
A
S
A
A
G
S
Site 81
S514
A
A
G
S
I
T
S
S
S
L
Q
K
S
P
T
Site 82
S515
A
G
S
I
T
S
S
S
L
Q
K
S
P
T
L
Site 83
S519
T
S
S
S
L
Q
K
S
P
T
L
L
R
N
G
Site 84
T521
S
S
L
Q
K
S
P
T
L
L
R
N
G
S
L
Site 85
S527
P
T
L
L
R
N
G
S
L
Q
S
L
S
V
G
Site 86
S530
L
R
N
G
S
L
Q
S
L
S
V
G
S
S
P
Site 87
S532
N
G
S
L
Q
S
L
S
V
G
S
S
P
V
G
Site 88
S536
Q
S
L
S
V
G
S
S
P
V
G
S
E
I
S
Site 89
S540
V
G
S
S
P
V
G
S
E
I
S
M
Q
Y
R
Site 90
S543
S
P
V
G
S
E
I
S
M
Q
Y
R
H
D
G
Site 91
T554
R
H
D
G
A
C
P
T
T
T
F
S
E
L
L
Site 92
T555
H
D
G
A
C
P
T
T
T
F
S
E
L
L
N
Site 93
T556
D
G
A
C
P
T
T
T
F
S
E
L
L
N
A
Site 94
S571
I
H
N
D
R
G
D
S
S
T
L
T
K
Q
E
Site 95
S572
H
N
D
R
G
D
S
S
T
L
T
K
Q
E
L
Site 96
T573
N
D
R
G
D
S
S
T
L
T
K
Q
E
L
K
Site 97
T575
R
G
D
S
S
T
L
T
K
Q
E
L
K
F
I
Site 98
S599
V
S
F
P
N
V
V
S
G
S
G
S
S
T
P
Site 99
S601
F
P
N
V
V
S
G
S
G
S
S
T
P
V
S
Site 100
S603
N
V
V
S
G
S
G
S
S
T
P
V
S
S
S
Site 101
S604
V
V
S
G
S
G
S
S
T
P
V
S
S
S
H
Site 102
T605
V
S
G
S
G
S
S
T
P
V
S
S
S
H
L
Site 103
S608
S
G
S
S
T
P
V
S
S
S
H
L
P
Q
Q
Site 104
S610
S
S
T
P
V
S
S
S
H
L
P
Q
Q
S
S
Site 105
S616
S
S
H
L
P
Q
Q
S
S
G
H
L
Q
Q
V
Site 106
S617
S
H
L
P
Q
Q
S
S
G
H
L
Q
Q
V
G
Site 107
T645
V
A
T
T
Q
A
N
T
L
S
G
S
S
L
S
Site 108
S647
T
T
Q
A
N
T
L
S
G
S
S
L
S
Q
A
Site 109
S650
A
N
T
L
S
G
S
S
L
S
Q
A
P
S
H
Site 110
S652
T
L
S
G
S
S
L
S
Q
A
P
S
H
M
Y
Site 111
S656
S
S
L
S
Q
A
P
S
H
M
Y
G
N
R
S
Site 112
Y659
S
Q
A
P
S
H
M
Y
G
N
R
S
N
S
S
Site 113
S663
S
H
M
Y
G
N
R
S
N
S
S
M
A
A
L
Site 114
S665
M
Y
G
N
R
S
N
S
S
M
A
A
L
I
A
Site 115
T679
A
Q
S
E
N
N
Q
T
D
Q
D
L
G
D
N
Site 116
S687
D
Q
D
L
G
D
N
S
R
N
L
V
G
R
G
Site 117
S695
R
N
L
V
G
R
G
S
S
P
R
G
S
L
S
Site 118
S696
N
L
V
G
R
G
S
S
P
R
G
S
L
S
P
Site 119
S700
R
G
S
S
P
R
G
S
L
S
P
R
S
P
V
Site 120
S702
S
S
P
R
G
S
L
S
P
R
S
P
V
S
S
Site 121
S705
R
G
S
L
S
P
R
S
P
V
S
S
L
Q
I
Site 122
S708
L
S
P
R
S
P
V
S
S
L
Q
I
R
Y
D
Site 123
S709
S
P
R
S
P
V
S
S
L
Q
I
R
Y
D
Q
Site 124
Y714
V
S
S
L
Q
I
R
Y
D
Q
P
G
N
S
S
Site 125
S721
Y
D
Q
P
G
N
S
S
L
E
N
L
P
P
V
Site 126
S731
N
L
P
P
V
A
A
S
I
E
Q
L
L
E
R
Site 127
S741
Q
L
L
E
R
Q
W
S
E
G
Q
Q
F
L
L
Site 128
T802
S
V
P
F
P
T
I
T
A
N
P
S
P
S
H
Site 129
S806
P
T
I
T
A
N
P
S
P
S
H
Q
I
H
T
Site 130
S808
I
T
A
N
P
S
P
S
H
Q
I
H
T
F
S
Site 131
T813
S
P
S
H
Q
I
H
T
F
S
A
Q
T
A
P
Site 132
T822
S
A
Q
T
A
P
T
T
D
S
L
N
S
S
K
Site 133
S824
Q
T
A
P
T
T
D
S
L
N
S
S
K
S
P
Site 134
S828
T
T
D
S
L
N
S
S
K
S
P
H
I
G
N
Site 135
S830
D
S
L
N
S
S
K
S
P
H
I
G
N
S
F
Site 136
S836
K
S
P
H
I
G
N
S
F
L
P
D
N
S
L
Site 137
S842
N
S
F
L
P
D
N
S
L
P
V
L
N
Q
D
Site 138
T851
P
V
L
N
Q
D
L
T
S
S
G
Q
S
T
S
Site 139
S852
V
L
N
Q
D
L
T
S
S
G
Q
S
T
S
S
Site 140
S853
L
N
Q
D
L
T
S
S
G
Q
S
T
S
S
S
Site 141
S856
D
L
T
S
S
G
Q
S
T
S
S
S
S
A
L
Site 142
T857
L
T
S
S
G
Q
S
T
S
S
S
S
A
L
S
Site 143
S858
T
S
S
G
Q
S
T
S
S
S
S
A
L
S
T
Site 144
S859
S
S
G
Q
S
T
S
S
S
S
A
L
S
T
P
Site 145
S860
S
G
Q
S
T
S
S
S
S
A
L
S
T
P
P
Site 146
S861
G
Q
S
T
S
S
S
S
A
L
S
T
P
P
P
Site 147
S864
T
S
S
S
S
A
L
S
T
P
P
P
A
G
Q
Site 148
T865
S
S
S
S
A
L
S
T
P
P
P
A
G
Q
S
Site 149
S872
T
P
P
P
A
G
Q
S
P
A
Q
Q
G
S
G
Site 150
S878
Q
S
P
A
Q
Q
G
S
G
V
S
G
V
Q
Q
Site 151
T938
A
L
N
G
V
M
Q
T
P
V
T
M
S
Q
N
Site 152
T941
G
V
M
Q
T
P
V
T
M
S
Q
N
P
T
P
Site 153
S943
M
Q
T
P
V
T
M
S
Q
N
P
T
P
L
T
Site 154
T947
V
T
M
S
Q
N
P
T
P
L
T
H
T
T
V
Site 155
T950
S
Q
N
P
T
P
L
T
H
T
T
V
P
P
N
Site 156
T953
P
T
P
L
T
H
T
T
V
P
P
N
A
T
H
Site 157
T965
A
T
H
P
M
P
A
T
L
T
N
S
A
S
G
Site 158
T967
H
P
M
P
A
T
L
T
N
S
A
S
G
L
G
Site 159
S977
A
S
G
L
G
L
L
S
D
Q
Q
R
Q
I
L
Site 160
S996
Q
F
Q
Q
L
L
N
S
Q
Q
L
T
P
V
H
Site 161
T1000
L
L
N
S
Q
Q
L
T
P
V
H
R
H
P
H
Site 162
T1014
H
F
T
Q
L
P
P
T
H
F
S
P
S
M
E
Site 163
S1017
Q
L
P
P
T
H
F
S
P
S
M
E
I
M
Q
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation