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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
Casp7
Full Name:
Caspase-7
Alias:
Apoptotic protease Mch-3; CASP-7; Caspase 7, apoptosis-related cysteine peptidase; Caspase 7, apoptosis-related cysteine protease; CMH-1; EC 3.4.22.60; ICE-LAP3; ICE-like apoptotic protease 3; Lice2 alpha/beta/gamma; MCH3
Type:
Mitochondrial membrane, Cytoplasm, Endoplasmic reticulum membrane protein
Mass (Da):
34277
Number AA:
303
UniProt ID:
P55210
International Prot ID:
IPI00216675
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005829
GO:0005789
GO:0031966
Uniprot
OncoNet
Molecular Function:
GO:0004197
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0006508
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S16
E
E
Q
G
V
E
D
S
A
N
E
D
S
V
D
Site 2
S21
E
D
S
A
N
E
D
S
V
D
A
K
P
D
R
Site 3
S29
V
D
A
K
P
D
R
S
S
F
V
P
S
L
F
Site 4
S30
D
A
K
P
D
R
S
S
F
V
P
S
L
F
S
Site 5
S34
D
R
S
S
F
V
P
S
L
F
S
K
K
K
K
Site 6
S37
S
F
V
P
S
L
F
S
K
K
K
K
N
V
T
Site 7
T44
S
K
K
K
K
N
V
T
M
R
S
I
K
T
T
Site 8
S47
K
K
N
V
T
M
R
S
I
K
T
T
R
D
R
Site 9
T50
V
T
M
R
S
I
K
T
T
R
D
R
V
P
T
Site 10
T51
T
M
R
S
I
K
T
T
R
D
R
V
P
T
Y
Site 11
Y58
T
R
D
R
V
P
T
Y
Q
Y
N
M
N
F
E
Site 12
Y60
D
R
V
P
T
Y
Q
Y
N
M
N
F
E
K
L
Site 13
T90
G
M
G
V
R
N
G
T
D
K
D
A
E
A
L
Site 14
S127
Q
D
L
L
K
K
A
S
E
E
D
H
T
N
A
Site 15
T132
K
A
S
E
E
D
H
T
N
A
A
C
F
A
C
Site 16
Y151
H
G
E
E
N
V
I
Y
G
K
D
G
V
T
P
Site 17
T157
I
Y
G
K
D
G
V
T
P
I
K
D
L
T
A
Site 18
T163
V
T
P
I
K
D
L
T
A
H
F
R
G
D
R
Site 19
T173
F
R
G
D
R
C
K
T
L
L
E
K
P
K
L
Site 20
T189
F
I
Q
A
C
R
G
T
E
L
D
D
G
I
Q
Site 21
S199
D
D
G
I
Q
A
D
S
G
P
I
N
D
T
D
Site 22
T205
D
S
G
P
I
N
D
T
D
A
N
P
R
Y
K
Site 23
Y211
D
T
D
A
N
P
R
Y
K
I
P
V
E
A
D
Site 24
Y229
A
Y
S
T
V
P
G
Y
Y
S
W
R
S
P
G
Site 25
Y230
Y
S
T
V
P
G
Y
Y
S
W
R
S
P
G
R
Site 26
S231
S
T
V
P
G
Y
Y
S
W
R
S
P
G
R
G
Site 27
S234
P
G
Y
Y
S
W
R
S
P
G
R
G
S
W
F
Site 28
S239
W
R
S
P
G
R
G
S
W
F
V
Q
A
L
C
Site 29
S275
R
V
A
R
H
F
E
S
Q
S
D
D
P
H
F
Site 30
S277
A
R
H
F
E
S
Q
S
D
D
P
H
F
H
E
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation