KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
ADAR
Full Name:
Double-stranded RNA-specific adenosine deaminase
Alias:
136 kDa double-stranded RNA binding protein; 136 kDa double-stranded RNA-binding protein; ADAR1; Adenosine deaminase, RNA-specific; Double-stranded RNA-specific adenosine deaminase; DRADA; DSH; DSRAD; G1P1; IFI4; IFI-4 protein; Interferon-inducible protein 4; P136
Type:
EC 3.5.4.-; Hydrolase; RNA processing
Mass (Da):
135967
Number AA:
1226
UniProt ID:
P55265
International Prot ID:
IPI00025057
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005730
Uniprot
OncoNet
Molecular Function:
GO:0003677
GO:0003726
GO:0003725
PhosphoSite+
KinaseNET
Biological Process:
GO:0016553
GO:0031047
GO:0006397
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y7
_
M
N
P
R
Q
G
Y
S
L
S
G
Y
Y
T
Site 2
S8
M
N
P
R
Q
G
Y
S
L
S
G
Y
Y
T
H
Site 3
S10
P
R
Q
G
Y
S
L
S
G
Y
Y
T
H
P
F
Site 4
Y12
Q
G
Y
S
L
S
G
Y
Y
T
H
P
F
Q
G
Site 5
Y13
G
Y
S
L
S
G
Y
Y
T
H
P
F
Q
G
Y
Site 6
T14
Y
S
L
S
G
Y
Y
T
H
P
F
Q
G
Y
E
Site 7
Y20
Y
T
H
P
F
Q
G
Y
E
H
R
Q
L
R
Y
Site 8
Y27
Y
E
H
R
Q
L
R
Y
Q
Q
P
G
P
G
S
Site 9
S34
Y
Q
Q
P
G
P
G
S
S
P
S
S
F
L
L
Site 10
S35
Q
Q
P
G
P
G
S
S
P
S
S
F
L
L
K
Site 11
S37
P
G
P
G
S
S
P
S
S
F
L
L
K
Q
I
Site 12
S38
G
P
G
S
S
P
S
S
F
L
L
K
Q
I
E
Site 13
T61
A
P
V
I
G
K
Q
T
P
S
L
P
P
S
L
Site 14
S63
V
I
G
K
Q
T
P
S
L
P
P
S
L
P
G
Site 15
S67
Q
T
P
S
L
P
P
S
L
P
G
L
R
P
R
Site 16
S81
R
F
P
V
L
L
A
S
S
T
R
G
R
Q
V
Site 17
S82
F
P
V
L
L
A
S
S
T
R
G
R
Q
V
D
Site 18
S101
P
R
G
V
H
L
G
S
Q
G
L
Q
R
G
F
Site 19
S112
Q
R
G
F
Q
H
P
S
P
R
G
R
S
L
P
Site 20
S117
H
P
S
P
R
G
R
S
L
P
Q
R
G
V
D
Site 21
S127
Q
R
G
V
D
C
L
S
S
H
F
Q
E
L
S
Site 22
S128
R
G
V
D
C
L
S
S
H
F
Q
E
L
S
I
Site 23
S134
S
S
H
F
Q
E
L
S
I
Y
Q
D
Q
E
Q
Site 24
Y136
H
F
Q
E
L
S
I
Y
Q
D
Q
E
Q
R
I
Site 25
T156
E
L
G
E
G
K
A
T
T
A
H
D
L
S
G
Site 26
T167
D
L
S
G
K
L
G
T
P
K
K
E
I
N
R
Site 27
Y177
K
E
I
N
R
V
L
Y
S
L
A
K
K
G
K
Site 28
S178
E
I
N
R
V
L
Y
S
L
A
K
K
G
K
L
Site 29
T191
K
L
Q
K
E
A
G
T
P
P
L
W
K
I
A
Site 30
S217
V
V
R
P
D
G
H
S
Q
G
A
P
N
S
D
Site 31
S223
H
S
Q
G
A
P
N
S
D
P
S
L
E
P
E
Site 32
S226
G
A
P
N
S
D
P
S
L
E
P
E
D
R
N
Site 33
S234
L
E
P
E
D
R
N
S
T
S
V
S
E
D
L
Site 34
T235
E
P
E
D
R
N
S
T
S
V
S
E
D
L
L
Site 35
S236
P
E
D
R
N
S
T
S
V
S
E
D
L
L
E
Site 36
S238
D
R
N
S
T
S
V
S
E
D
L
L
E
P
F
Site 37
S264
S
G
V
V
R
P
D
S
H
S
Q
G
S
P
N
Site 38
S266
V
V
R
P
D
S
H
S
Q
G
S
P
N
S
D
Site 39
S269
P
D
S
H
S
Q
G
S
P
N
S
D
P
G
L
Site 40
S272
H
S
Q
G
S
P
N
S
D
P
G
L
E
P
E
Site 41
S281
P
G
L
E
P
E
D
S
N
S
T
S
A
L
E
Site 42
S283
L
E
P
E
D
S
N
S
T
S
A
L
E
D
P
Site 43
S285
P
E
D
S
N
S
T
S
A
L
E
D
P
L
E
Site 44
Y306
I
K
E
K
I
C
D
Y
L
F
N
V
S
D
S
Site 45
Y344
M
E
R
Q
G
D
V
Y
R
Q
G
T
T
P
P
Site 46
T348
G
D
V
Y
R
Q
G
T
T
P
P
I
W
H
L
Site 47
T349
D
V
Y
R
Q
G
T
T
P
P
I
W
H
L
T
Site 48
T356
T
P
P
I
W
H
L
T
D
K
K
R
E
R
M
Site 49
T369
R
M
Q
I
K
R
N
T
N
S
V
P
E
T
A
Site 50
T375
N
T
N
S
V
P
E
T
A
P
A
A
I
P
E
Site 51
T383
A
P
A
A
I
P
E
T
K
R
N
A
E
F
L
Site 52
T391
K
R
N
A
E
F
L
T
C
N
I
P
T
S
N
Site 53
Y438
R
L
K
P
P
V
H
Y
N
G
P
S
K
A
G
Site 54
Y446
N
G
P
S
K
A
G
Y
V
D
F
E
N
G
Q
Site 55
S465
D
I
P
D
D
L
N
S
I
R
A
A
P
G
E
Site 56
S481
R
A
I
M
E
M
P
S
F
Y
S
H
G
L
P
Site 57
Y483
I
M
E
M
P
S
F
Y
S
H
G
L
P
R
C
Site 58
S484
M
E
M
P
S
F
Y
S
H
G
L
P
R
C
S
Site 59
S491
S
H
G
L
P
R
C
S
P
Y
K
K
L
T
E
Site 60
T497
C
S
P
Y
K
K
L
T
E
C
Q
L
K
N
P
Site 61
S506
C
Q
L
K
N
P
I
S
G
L
L
E
Y
A
Q
Site 62
S527
E
F
N
M
I
E
Q
S
G
P
P
H
E
P
R
Site 63
T567
D
A
A
M
K
A
M
T
I
L
L
E
E
A
K
Site 64
S578
E
E
A
K
A
K
D
S
G
K
S
E
E
S
S
Site 65
S581
K
A
K
D
S
G
K
S
E
E
S
S
H
Y
S
Site 66
S584
D
S
G
K
S
E
E
S
S
H
Y
S
T
E
K
Site 67
S585
S
G
K
S
E
E
S
S
H
Y
S
T
E
K
E
Site 68
Y587
K
S
E
E
S
S
H
Y
S
T
E
K
E
S
E
Site 69
S588
S
E
E
S
S
H
Y
S
T
E
K
E
S
E
K
Site 70
T589
E
E
S
S
H
Y
S
T
E
K
E
S
E
K
T
Site 71
T596
T
E
K
E
S
E
K
T
A
E
S
Q
T
P
T
Site 72
S599
E
S
E
K
T
A
E
S
Q
T
P
T
P
S
A
Site 73
T601
E
K
T
A
E
S
Q
T
P
T
P
S
A
T
S
Site 74
T603
T
A
E
S
Q
T
P
T
P
S
A
T
S
F
F
Site 75
S605
E
S
Q
T
P
T
P
S
A
T
S
F
F
S
G
Site 76
T607
Q
T
P
T
P
S
A
T
S
F
F
S
G
K
S
Site 77
S608
T
P
T
P
S
A
T
S
F
F
S
G
K
S
P
Site 78
S611
P
S
A
T
S
F
F
S
G
K
S
P
V
T
T
Site 79
S614
T
S
F
F
S
G
K
S
P
V
T
T
L
L
E
Site 80
T618
S
G
K
S
P
V
T
T
L
L
E
C
M
H
K
Site 81
S629
C
M
H
K
L
G
N
S
C
E
F
R
L
L
S
Site 82
S636
S
C
E
F
R
L
L
S
K
E
G
P
A
H
E
Site 83
Y648
A
H
E
P
K
F
Q
Y
C
V
A
V
G
A
Q
Site 84
S659
V
G
A
Q
T
F
P
S
V
S
A
P
S
K
K
Site 85
S661
A
Q
T
F
P
S
V
S
A
P
S
K
K
V
A
Site 86
T685
K
A
L
H
G
E
A
T
N
S
M
A
S
D
N
Site 87
S687
L
H
G
E
A
T
N
S
M
A
S
D
N
Q
P
Site 88
S699
N
Q
P
E
G
M
I
S
E
S
L
D
N
L
E
Site 89
S701
P
E
G
M
I
S
E
S
L
D
N
L
E
S
M
Site 90
S707
E
S
L
D
N
L
E
S
M
M
P
N
K
V
R
Site 91
Y722
K
I
G
E
L
V
R
Y
L
N
T
N
P
V
G
Site 92
Y734
P
V
G
G
L
L
E
Y
A
R
S
H
G
F
A
Site 93
S737
G
L
L
E
Y
A
R
S
H
G
F
A
A
E
F
Site 94
S750
E
F
K
L
V
D
Q
S
G
P
P
H
E
P
K
Site 95
Y760
P
H
E
P
K
F
V
Y
Q
A
K
V
G
G
R
Site 96
T808
R
M
G
F
T
E
V
T
P
V
T
G
A
S
L
Site 97
S814
V
T
P
V
T
G
A
S
L
R
R
T
M
L
L
Site 98
T818
T
G
A
S
L
R
R
T
M
L
L
L
S
R
S
Site 99
S823
R
R
T
M
L
L
L
S
R
S
P
E
A
Q
P
Site 100
S825
T
M
L
L
L
S
R
S
P
E
A
Q
P
K
T
Site 101
T832
S
P
E
A
Q
P
K
T
L
P
L
T
G
S
T
Site 102
T836
Q
P
K
T
L
P
L
T
G
S
T
F
H
D
Q
Site 103
T854
L
S
H
R
C
F
N
T
L
T
N
S
F
Q
P
Site 104
T856
H
R
C
F
N
T
L
T
N
S
F
Q
P
S
L
Site 105
S898
N
R
C
V
K
G
D
S
L
S
L
K
G
E
T
Site 106
S900
C
V
K
G
D
S
L
S
L
K
G
E
T
V
N
Site 107
T905
S
L
S
L
K
G
E
T
V
N
D
C
H
A
E
Site 108
Y924
R
G
F
I
R
F
L
Y
S
E
L
M
K
Y
N
Site 109
Y930
L
Y
S
E
L
M
K
Y
N
S
Q
T
A
K
D
Site 110
S932
S
E
L
M
K
Y
N
S
Q
T
A
K
D
S
I
Site 111
T954
E
K
L
Q
I
K
K
T
V
S
F
H
L
Y
I
Site 112
S975
D
G
A
L
F
D
K
S
C
S
D
R
A
M
E
Site 113
S977
A
L
F
D
K
S
C
S
D
R
A
M
E
S
T
Site 114
S983
C
S
D
R
A
M
E
S
T
E
S
R
H
Y
P
Site 115
T984
S
D
R
A
M
E
S
T
E
S
R
H
Y
P
V
Site 116
S986
R
A
M
E
S
T
E
S
R
H
Y
P
V
F
E
Site 117
Y989
E
S
T
E
S
R
H
Y
P
V
F
E
N
P
K
Site 118
T1010
K
V
E
N
G
E
G
T
I
P
V
E
S
S
D
Site 119
S1016
G
T
I
P
V
E
S
S
D
I
V
P
T
W
D
Site 120
T1033
R
L
G
E
R
L
R
T
M
S
C
S
D
K
I
Site 121
S1035
G
E
R
L
R
T
M
S
C
S
D
K
I
L
R
Site 122
S1037
R
L
R
T
M
S
C
S
D
K
I
L
R
W
N
Site 123
T1085
R
A
I
C
C
R
V
T
R
D
G
S
A
F
E
Site 124
S1089
C
R
V
T
R
D
G
S
A
F
E
D
G
L
R
Site 125
S1110
H
P
K
V
G
R
V
S
I
Y
D
S
K
R
Q
Site 126
Y1112
K
V
G
R
V
S
I
Y
D
S
K
R
Q
S
G
Site 127
S1114
G
R
V
S
I
Y
D
S
K
R
Q
S
G
K
T
Site 128
S1118
I
Y
D
S
K
R
Q
S
G
K
T
K
E
T
S
Site 129
T1121
S
K
R
Q
S
G
K
T
K
E
T
S
V
N
W
Site 130
S1125
S
G
K
T
K
E
T
S
V
N
W
C
L
A
D
Site 131
Y1134
N
W
C
L
A
D
G
Y
D
L
E
I
L
D
G
Site 132
T1145
I
L
D
G
T
R
G
T
V
D
G
P
R
N
E
Site 133
S1154
D
G
P
R
N
E
L
S
R
V
S
K
K
N
I
Site 134
S1157
R
N
E
L
S
R
V
S
K
K
N
I
F
L
L
Site 135
S1170
L
L
F
K
K
L
C
S
F
R
Y
R
R
D
L
Site 136
Y1173
K
K
L
C
S
F
R
Y
R
R
D
L
L
R
L
Site 137
S1181
R
R
D
L
L
R
L
S
Y
G
E
A
K
K
A
Site 138
Y1182
R
D
L
L
R
L
S
Y
G
E
A
K
K
A
A
Site 139
Y1192
A
K
K
A
A
R
D
Y
E
T
A
K
N
Y
F
Site 140
Y1198
D
Y
E
T
A
K
N
Y
F
K
K
G
L
K
D
Site 141
Y1208
K
G
L
K
D
M
G
Y
G
N
W
I
S
K
P
Site 142
Y1222
P
Q
E
E
K
N
F
Y
L
C
P
V
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation