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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
NPEPPS
Full Name:
Puromycin-sensitive aminopeptidase
Alias:
Aminopeptidase puromycin sensitive; Metalloproteinase MP100; MP100; Puromycin-sensitive aminopeptidase-like protein
Type:
EC 3.4.11.-; Protease
Mass (Da):
103258
Number AA:
919
UniProt ID:
P55786
International Prot ID:
IPI00026216
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
GO:0005737
GO:0005829
Uniprot
OncoNet
Molecular Function:
GO:0003824
GO:0004177
GO:0005488
PhosphoSite+
KinaseNET
Biological Process:
GO:0006508
GO:0008152
GO:0009987
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S30
P
L
L
L
L
V
F
S
R
S
S
R
R
R
L
Site 2
S32
L
L
L
V
F
S
R
S
S
R
R
R
L
H
S
Site 3
S33
L
L
V
F
S
R
S
S
R
R
R
L
H
S
L
Site 4
S39
S
S
R
R
R
L
H
S
L
G
L
A
A
M
P
Site 5
S59
E
R
L
P
A
D
V
S
P
I
N
Y
S
L
C
Site 6
S64
D
V
S
P
I
N
Y
S
L
C
L
K
P
D
L
Site 7
T75
K
P
D
L
L
D
F
T
F
E
G
K
L
E
A
Site 8
T90
A
A
Q
V
R
Q
A
T
N
Q
I
V
M
N
C
Site 9
T118
G
D
E
E
I
H
A
T
G
F
N
Y
Q
N
E
Site 10
S132
E
D
E
K
V
T
L
S
F
P
S
T
L
Q
T
Site 11
T139
S
F
P
S
T
L
Q
T
G
T
G
T
L
K
I
Site 12
S162
K
M
K
G
F
Y
R
S
K
Y
T
T
P
S
G
Site 13
Y164
K
G
F
Y
R
S
K
Y
T
T
P
S
G
E
V
Site 14
T166
F
Y
R
S
K
Y
T
T
P
S
G
E
V
R
Y
Site 15
T177
E
V
R
Y
A
A
V
T
Q
F
E
A
T
D
A
Site 16
T199
D
E
P
A
I
K
A
T
F
D
I
S
L
V
V
Site 17
Y224
N
V
I
D
R
K
P
Y
P
D
D
E
N
L
V
Site 18
Y292
A
A
K
T
L
P
F
Y
K
D
Y
F
N
V
P
Site 19
Y295
T
L
P
F
Y
K
D
Y
F
N
V
P
Y
P
L
Site 20
Y300
K
D
Y
F
N
V
P
Y
P
L
P
K
I
D
L
Site 21
S338
L
L
I
D
P
K
N
S
C
S
S
S
R
Q
W
Site 22
S340
I
D
P
K
N
S
C
S
S
S
R
Q
W
V
A
Site 23
S341
D
P
K
N
S
C
S
S
S
R
Q
W
V
A
L
Site 24
S342
P
K
N
S
C
S
S
S
R
Q
W
V
A
L
V
Site 25
Y404
T
Q
F
V
S
A
D
Y
T
R
A
Q
E
L
D
Site 26
T405
Q
F
V
S
A
D
Y
T
R
A
Q
E
L
D
A
Site 27
S416
E
L
D
A
L
D
N
S
H
P
I
E
V
S
V
Site 28
S422
N
S
H
P
I
E
V
S
V
G
H
P
S
E
V
Site 29
S437
D
E
I
F
D
A
I
S
Y
S
K
G
A
S
V
Site 30
S443
I
S
Y
S
K
G
A
S
V
I
R
M
L
H
D
Site 31
Y451
V
I
R
M
L
H
D
Y
I
G
D
K
D
F
K
Site 32
Y464
F
K
K
G
M
N
M
Y
L
T
K
F
Q
Q
K
Site 33
S481
A
T
E
D
L
W
E
S
L
E
N
A
S
G
K
Site 34
S522
D
D
R
L
L
R
L
S
Q
K
K
F
C
A
G
Site 35
S531
K
K
F
C
A
G
G
S
Y
V
G
E
D
C
P
Site 36
Y532
K
F
C
A
G
G
S
Y
V
G
E
D
C
P
Q
Site 37
T545
P
Q
W
M
V
P
I
T
I
S
T
S
E
D
P
Site 38
S549
V
P
I
T
I
S
T
S
E
D
P
N
Q
A
K
Site 39
T591
G
T
V
G
F
Y
R
T
Q
Y
S
S
A
M
L
Site 40
Y593
V
G
F
Y
R
T
Q
Y
S
S
A
M
L
E
S
Site 41
S594
G
F
Y
R
T
Q
Y
S
S
A
M
L
E
S
L
Site 42
S595
F
Y
R
T
Q
Y
S
S
A
M
L
E
S
L
L
Site 43
S600
Y
S
S
A
M
L
E
S
L
L
P
G
I
R
D
Site 44
Y649
A
F
V
N
E
P
N
Y
T
V
W
S
D
L
S
Site 45
T650
F
V
N
E
P
N
Y
T
V
W
S
D
L
S
C
Site 46
S667
G
I
L
S
T
L
L
S
H
T
D
F
Y
E
E
Site 47
Y672
L
L
S
H
T
D
F
Y
E
E
I
Q
E
F
V
Site 48
S684
E
F
V
K
D
V
F
S
P
I
G
E
R
L
G
Site 49
S740
V
E
G
K
Q
I
L
S
A
D
L
R
S
P
V
Site 50
T750
L
R
S
P
V
Y
L
T
V
L
K
H
G
D
G
Site 51
S801
K
V
L
T
F
A
L
S
E
E
V
R
P
Q
D
Site 52
T809
E
E
V
R
P
Q
D
T
V
S
V
I
G
G
V
Site 53
S820
I
G
G
V
A
G
G
S
K
H
G
R
K
A
A
Site 54
Y839
K
D
N
W
E
E
L
Y
N
R
Y
Q
G
G
F
Site 55
Y842
W
E
E
L
Y
N
R
Y
Q
G
G
F
L
I
S
Site 56
S874
E
V
K
A
F
F
E
S
H
P
A
P
S
A
E
Site 57
T883
P
A
P
S
A
E
R
T
I
Q
Q
C
C
E
N
Site 58
Y908
D
A
E
S
I
H
Q
Y
L
L
Q
R
K
A
S
Site 59
S915
Y
L
L
Q
R
K
A
S
P
P
T
V
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation