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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
EIF3B
Full Name:
Eukaryotic translation initiation factor 3 subunit B
Alias:
eIF-3 eta; eIF3 p110; eIF3 p116; eIF3b; EIF3S9; Eukaryotic translation initiation factor 3 subunit 9; eukaryotic translation initiation factor 3, subunit B; IF39; PRT1
Type:
Translation protein, initiation complex
Mass (Da):
92482
Number AA:
814
UniProt ID:
P55884
International Prot ID:
IPI00396370
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005829
GO:0005852
GO:0032991
Uniprot
OncoNet
Molecular Function:
GO:0003723
GO:0000166
GO:0032947
PhosphoSite+
KinaseNET
Biological Process:
GO:0006446
GO:0006413
GO:0008152
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T48
G
A
P
E
A
A
G
T
E
A
S
S
E
E
V
Site 2
S64
I
A
E
A
G
P
E
S
E
V
R
T
E
P
A
Site 3
T68
G
P
E
S
E
V
R
T
E
P
A
A
E
A
E
Site 4
S78
A
A
E
A
E
A
A
S
G
P
S
E
S
P
S
Site 5
S81
A
E
A
A
S
G
P
S
E
S
P
S
P
P
A
Site 6
S83
A
A
S
G
P
S
E
S
P
S
P
P
A
A
E
Site 7
S85
S
G
P
S
E
S
P
S
P
P
A
A
E
E
L
Site 8
S95
A
A
E
E
L
P
G
S
H
A
E
P
P
V
P
Site 9
S117
E
Q
A
R
D
E
R
S
D
S
R
A
Q
A
V
Site 10
S119
A
R
D
E
R
S
D
S
R
A
Q
A
V
S
E
Site 11
S125
D
S
R
A
Q
A
V
S
E
D
A
G
G
N
E
Site 12
S152
N
G
D
A
D
E
P
S
F
S
D
P
E
D
F
Site 13
S154
D
A
D
E
P
S
F
S
D
P
E
D
F
V
D
Site 14
S164
E
D
F
V
D
D
V
S
E
E
E
L
L
G
D
Site 15
Y222
G
K
I
T
N
D
F
Y
P
E
E
D
G
K
T
Site 16
T229
Y
P
E
E
D
G
K
T
K
G
Y
I
F
L
E
Site 17
Y232
E
D
G
K
T
K
G
Y
I
F
L
E
Y
A
S
Site 18
Y237
K
G
Y
I
F
L
E
Y
A
S
P
A
H
A
V
Site 19
S239
Y
I
F
L
E
Y
A
S
P
A
H
A
V
D
A
Site 20
Y253
A
V
K
N
A
D
G
Y
K
L
D
K
Q
H
T
Site 21
T260
Y
K
L
D
K
Q
H
T
F
R
V
N
L
F
T
Site 22
T267
T
F
R
V
N
L
F
T
D
F
D
K
Y
M
T
Site 23
Y272
L
F
T
D
F
D
K
Y
M
T
I
S
D
E
W
Site 24
Y295
K
D
L
G
N
L
R
Y
W
L
E
E
A
E
C
Site 25
Y306
E
A
E
C
R
D
Q
Y
S
V
I
F
E
S
G
Site 26
S307
A
E
C
R
D
Q
Y
S
V
I
F
E
S
G
D
Site 27
S312
Q
Y
S
V
I
F
E
S
G
D
R
T
S
I
F
Site 28
S317
F
E
S
G
D
R
T
S
I
F
W
N
D
V
K
Site 29
S328
N
D
V
K
D
P
V
S
I
E
E
R
A
R
W
Site 30
T336
I
E
E
R
A
R
W
T
E
T
Y
V
R
W
S
Site 31
T338
E
R
A
R
W
T
E
T
Y
V
R
W
S
P
K
Site 32
Y339
R
A
R
W
T
E
T
Y
V
R
W
S
P
K
G
Site 33
S343
T
E
T
Y
V
R
W
S
P
K
G
T
Y
L
A
Site 34
T347
V
R
W
S
P
K
G
T
Y
L
A
T
F
H
Q
Site 35
Y348
R
W
S
P
K
G
T
Y
L
A
T
F
H
Q
R
Site 36
T351
P
K
G
T
Y
L
A
T
F
H
Q
R
G
I
A
Site 37
Y387
D
F
S
P
C
E
R
Y
L
V
T
F
S
P
L
Site 38
T390
P
C
E
R
Y
L
V
T
F
S
P
L
M
D
T
Site 39
S392
E
R
Y
L
V
T
F
S
P
L
M
D
T
Q
D
Site 40
T397
T
F
S
P
L
M
D
T
Q
D
D
P
Q
A
I
Site 41
T445
F
A
R
M
T
L
D
T
L
S
I
Y
E
T
P
Site 42
S447
R
M
T
L
D
T
L
S
I
Y
E
T
P
S
M
Site 43
Y449
T
L
D
T
L
S
I
Y
E
T
P
S
M
G
L
Site 44
T451
D
T
L
S
I
Y
E
T
P
S
M
G
L
L
D
Site 45
S461
M
G
L
L
D
K
K
S
L
K
I
S
G
I
K
Site 46
S465
D
K
K
S
L
K
I
S
G
I
K
D
F
S
W
Site 47
S471
I
S
G
I
K
D
F
S
W
S
P
G
G
N
I
Site 48
S473
G
I
K
D
F
S
W
S
P
G
G
N
I
I
A
Site 49
T494
K
D
I
P
A
R
V
T
L
M
Q
L
P
T
R
Site 50
T500
V
T
L
M
Q
L
P
T
R
Q
E
I
R
V
R
Site 51
Y525
H
W
Q
K
N
G
D
Y
L
C
V
K
V
D
R
Site 52
T533
L
C
V
K
V
D
R
T
P
K
G
T
Q
G
V
Site 53
T537
V
D
R
T
P
K
G
T
Q
G
V
V
T
N
F
Site 54
S588
H
G
E
A
P
R
I
S
V
S
F
Y
H
V
K
Site 55
S590
E
A
P
R
I
S
V
S
F
Y
H
V
K
N
N
Site 56
Y592
P
R
I
S
V
S
F
Y
H
V
K
N
N
G
K
Site 57
T662
S
D
V
E
W
D
P
T
G
R
Y
V
V
T
S
Site 58
Y665
E
W
D
P
T
G
R
Y
V
V
T
S
V
S
W
Site 59
T710
L
W
R
P
R
P
P
T
L
L
S
Q
E
Q
I
Site 60
S713
P
R
P
P
T
L
L
S
Q
E
Q
I
K
Q
I
Site 61
Y727
I
K
K
D
L
K
K
Y
S
K
I
F
E
Q
K
Site 62
S728
K
K
D
L
K
K
Y
S
K
I
F
E
Q
K
D
Site 63
S738
F
E
Q
K
D
R
L
S
Q
S
K
A
S
K
E
Site 64
S740
Q
K
D
R
L
S
Q
S
K
A
S
K
E
L
V
Site 65
T752
E
L
V
E
R
R
R
T
M
M
E
D
F
R
K
Site 66
Y760
M
M
E
D
F
R
K
Y
R
K
M
A
Q
E
L
Site 67
Y768
R
K
M
A
Q
E
L
Y
M
E
Q
K
N
E
R
Site 68
T784
E
L
R
G
G
V
D
T
D
E
L
D
S
N
V
Site 69
S789
V
D
T
D
E
L
D
S
N
V
D
D
W
E
E
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation