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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
RAG2
Full Name:
V(D)J recombination-activating protein 2
Alias:
RAG-2; recombination activating gene 2; V(D)J recombination activating protein 2
Type:
Enzyme, misc.
Mass (Da):
59241
Number AA:
527
UniProt ID:
P55895
International Prot ID:
IPI00299162
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0003677
GO:0004519
PhosphoSite+
KinaseNET
Biological Process:
GO:0016445
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S66
P
T
I
F
S
K
D
S
C
Y
L
P
P
L
R
Site 2
Y68
I
F
S
K
D
S
C
Y
L
P
P
L
R
Y
P
Site 3
Y74
C
Y
L
P
P
L
R
Y
P
A
T
C
T
F
K
Site 4
T77
P
P
L
R
Y
P
A
T
C
T
F
K
G
S
L
Site 5
T79
L
R
Y
P
A
T
C
T
F
K
G
S
L
E
S
Site 6
S83
A
T
C
T
F
K
G
S
L
E
S
E
K
H
Q
Site 7
Y91
L
E
S
E
K
H
Q
Y
I
I
H
G
G
K
T
Site 8
T98
Y
I
I
H
G
G
K
T
P
N
N
E
V
S
D
Site 9
S104
K
T
P
N
N
E
V
S
D
K
I
Y
V
M
S
Site 10
T125
K
K
V
T
F
R
C
T
E
K
D
L
V
G
D
Site 11
Y138
G
D
V
P
E
A
R
Y
G
H
S
I
N
V
V
Site 12
Y146
G
H
S
I
N
V
V
Y
S
R
G
K
S
M
G
Site 13
S147
H
S
I
N
V
V
Y
S
R
G
K
S
M
G
V
Site 14
S160
G
V
L
F
G
G
R
S
Y
M
P
S
T
H
R
Site 15
Y161
V
L
F
G
G
R
S
Y
M
P
S
T
H
R
T
Site 16
S164
G
G
R
S
Y
M
P
S
T
H
R
T
T
E
K
Site 17
T165
G
R
S
Y
M
P
S
T
H
R
T
T
E
K
W
Site 18
T168
Y
M
P
S
T
H
R
T
T
E
K
W
N
S
V
Site 19
T169
M
P
S
T
H
R
T
T
E
K
W
N
S
V
A
Site 20
Y195
E
F
G
C
A
T
S
Y
I
L
P
E
L
Q
D
Site 21
S205
P
E
L
Q
D
G
L
S
F
H
V
S
I
A
K
Site 22
S209
D
G
L
S
F
H
V
S
I
A
K
N
D
T
I
Site 23
Y234
N
I
R
P
A
N
L
Y
R
I
R
V
D
L
P
Site 24
T264
S
V
S
S
A
I
L
T
Q
T
N
N
D
E
F
Site 25
T304
I
E
I
R
E
M
E
T
P
D
W
T
P
D
I
Site 26
T308
E
M
E
T
P
D
W
T
P
D
I
K
H
S
K
Site 27
Y346
V
S
E
G
F
Y
F
Y
M
L
K
C
A
E
D
Site 28
T355
L
K
C
A
E
D
D
T
N
E
E
Q
T
T
F
Site 29
T361
D
T
N
E
E
Q
T
T
F
T
N
S
Q
T
S
Site 30
S365
E
Q
T
T
F
T
N
S
Q
T
S
T
E
D
P
Site 31
T369
F
T
N
S
Q
T
S
T
E
D
P
G
D
S
T
Site 32
S375
S
T
E
D
P
G
D
S
T
P
F
E
D
S
E
Site 33
T376
T
E
D
P
G
D
S
T
P
F
E
D
S
E
E
Site 34
S381
D
S
T
P
F
E
D
S
E
E
F
C
F
S
A
Site 35
S387
D
S
E
E
F
C
F
S
A
E
A
N
S
F
D
Site 36
S392
C
F
S
A
E
A
N
S
F
D
G
D
D
E
F
Site 37
T401
D
G
D
D
E
F
D
T
Y
N
E
D
D
E
E
Site 38
Y402
G
D
D
E
F
D
T
Y
N
E
D
D
E
E
D
Site 39
S411
E
D
D
E
E
D
E
S
E
T
G
Y
W
I
T
Site 40
Y415
E
D
E
S
E
T
G
Y
W
I
T
C
C
P
T
Site 41
Y445
L
N
K
P
A
M
I
Y
C
S
H
G
D
G
H
Site 42
S470
E
R
T
L
I
H
L
S
A
G
S
N
K
Y
Y
Site 43
Y476
L
S
A
G
S
N
K
Y
Y
C
N
E
H
V
E
Site 44
Y477
S
A
G
S
N
K
Y
Y
C
N
E
H
V
E
I
Site 45
T490
E
I
A
R
A
L
H
T
P
Q
R
V
L
P
L
Site 46
S504
L
K
K
P
P
M
K
S
L
R
K
K
G
S
G
Site 47
S510
K
S
L
R
K
K
G
S
G
K
I
L
T
P
A
Site 48
T515
K
G
S
G
K
I
L
T
P
A
K
K
S
F
L
Site 49
S520
I
L
T
P
A
K
K
S
F
L
R
R
L
F
D
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation