KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
GFRA1
Full Name:
GDNF family receptor alpha-1
Alias:
RET ligand 1;TGF-beta-related neurotrophic factor receptor 1
Type:
Mass (Da):
51456
Number AA:
465
UniProt ID:
P56159
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S33
R
L
D
C
V
K
A
S
D
Q
C
L
K
E
Q
Site 2
S43
C
L
K
E
Q
S
C
S
T
K
Y
R
T
L
R
Site 3
T48
S
C
S
T
K
Y
R
T
L
R
Q
C
V
A
G
Site 4
S61
A
G
K
E
T
N
F
S
L
A
S
G
L
E
A
Site 5
Y85
A
L
K
Q
K
S
L
Y
N
C
R
C
K
R
G
Site 6
Y103
E
K
N
C
L
R
I
Y
W
S
M
Y
Q
S
L
Site 7
Y107
L
R
I
Y
W
S
M
Y
Q
S
L
Q
G
N
D
Site 8
S119
G
N
D
L
L
E
D
S
P
Y
E
P
V
N
S
Site 9
Y121
D
L
L
E
D
S
P
Y
E
P
V
N
S
R
L
Site 10
S126
S
P
Y
E
P
V
N
S
R
L
S
D
I
F
R
Site 11
S129
E
P
V
N
S
R
L
S
D
I
F
R
V
V
P
Site 12
Y170
L
D
D
I
C
K
K
Y
R
S
A
Y
I
T
P
Site 13
Y174
C
K
K
Y
R
S
A
Y
I
T
P
C
T
T
S
Site 14
T176
K
Y
R
S
A
Y
I
T
P
C
T
T
S
V
S
Site 15
T179
S
A
Y
I
T
P
C
T
T
S
V
S
N
D
V
Site 16
T222
S
C
R
D
I
A
C
T
E
R
R
R
Q
T
I
Site 17
T228
C
T
E
R
R
R
Q
T
I
V
P
V
C
S
Y
Site 18
Y235
T
I
V
P
V
C
S
Y
E
E
R
E
K
P
N
Site 19
Y254
Q
D
S
C
K
T
N
Y
I
C
R
S
R
L
A
Site 20
T265
S
R
L
A
D
F
F
T
N
C
Q
P
E
S
R
Site 21
S271
F
T
N
C
Q
P
E
S
R
S
V
S
S
C
L
Site 22
S273
N
C
Q
P
E
S
R
S
V
S
S
C
L
K
E
Site 23
S275
Q
P
E
S
R
S
V
S
S
C
L
K
E
N
Y
Site 24
Y282
S
S
C
L
K
E
N
Y
A
D
C
L
L
A
Y
Site 25
Y301
G
T
V
M
T
P
N
Y
I
D
S
S
S
L
S
Site 26
S304
M
T
P
N
Y
I
D
S
S
S
L
S
V
A
P
Site 27
S306
P
N
Y
I
D
S
S
S
L
S
V
A
P
W
C
Site 28
T352
F
G
N
G
S
D
V
T
V
W
Q
P
A
F
P
Site 29
S383
K
P
L
G
P
A
G
S
E
N
E
I
P
T
H
Site 30
S405
L
Q
A
Q
K
L
K
S
N
V
S
G
N
T
H
Site 31
S408
Q
K
L
K
S
N
V
S
G
N
T
H
L
C
I
Site 32
Y420
L
C
I
S
N
G
N
Y
E
K
E
G
L
G
A
Site 33
S429
K
E
G
L
G
A
S
S
H
I
T
T
K
S
M
Site 34
T432
L
G
A
S
S
H
I
T
T
K
S
M
A
A
P
Site 35
T433
G
A
S
S
H
I
T
T
K
S
M
A
A
P
P
Site 36
S435
S
S
H
I
T
T
K
S
M
A
A
P
P
S
C
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation