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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
MARS
Full Name:
Methionyl-tRNA synthetase, cytoplasmic
Alias:
Methionine tRNA ligase 1, cytoplasmic; Methionine-tRNA ligase; Methionyl-tRNA synthetase; Methionyl-tRNA synthetase, cytoplasmic: Methionine--tRNA ligase; MetRS; SYMC
Type:
Other Amino Acids Metabolism - selenoamino acid; EC 6.1.1.10; Ligase
Mass (Da):
101116
Number AA:
900
UniProt ID:
P56192
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005829
GO:0005886
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0004825
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0006431
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S61
D
S
G
N
Y
L
F
S
T
S
A
I
C
R
Y
Site 2
T90
Q
W
L
E
W
E
A
T
E
L
Q
P
A
L
S
Site 3
S116
K
G
E
D
V
L
G
S
V
R
R
A
L
T
H
Site 4
T122
G
S
V
R
R
A
L
T
H
I
D
H
S
L
S
Site 5
S127
A
L
T
H
I
D
H
S
L
S
R
Q
N
C
P
Site 6
Y161
P
L
L
Q
D
P
A
Y
L
P
E
E
L
S
A
Site 7
S167
A
Y
L
P
E
E
L
S
A
L
H
S
W
F
Q
Site 8
S171
E
E
L
S
A
L
H
S
W
F
Q
T
L
S
T
Site 9
T175
A
L
H
S
W
F
Q
T
L
S
T
Q
E
P
C
Site 10
T178
S
W
F
Q
T
L
S
T
Q
E
P
C
Q
R
A
Site 11
Y201
G
V
L
A
L
R
P
Y
L
Q
K
Q
P
Q
P
Site 12
S209
L
Q
K
Q
P
Q
P
S
P
A
E
G
R
A
V
Site 13
T217
P
A
E
G
R
A
V
T
N
E
P
E
E
E
E
Site 14
T227
P
E
E
E
E
L
A
T
L
S
E
E
E
I
A
Site 15
S229
E
E
E
L
A
T
L
S
E
E
E
I
A
M
A
Site 16
S246
A
W
E
K
G
L
E
S
L
P
P
L
R
P
Q
Site 17
Y297
S
A
D
V
F
A
R
Y
S
R
L
R
Q
W
N
Site 18
Y307
L
R
Q
W
N
T
L
Y
L
C
G
T
D
E
Y
Site 19
Y314
Y
L
C
G
T
D
E
Y
G
T
A
T
E
T
K
Site 20
T328
K
A
L
E
E
G
L
T
P
Q
E
I
C
D
K
Site 21
Y336
P
Q
E
I
C
D
K
Y
H
I
I
H
A
D
I
Site 22
Y344
H
I
I
H
A
D
I
Y
R
W
F
N
I
S
F
Site 23
T357
S
F
D
I
F
G
R
T
T
T
P
Q
Q
T
K
Site 24
T358
F
D
I
F
G
R
T
T
T
P
Q
Q
T
K
I
Site 25
T359
D
I
F
G
R
T
T
T
P
Q
Q
T
K
I
T
Site 26
T383
R
G
F
V
L
Q
D
T
V
E
Q
L
R
C
E
Site 27
Y410
G
V
C
P
F
C
G
Y
E
E
A
R
G
D
Q
Site 28
S440
P
Q
C
K
V
C
R
S
C
P
V
V
Q
S
S
Site 29
T468
L
E
E
W
L
G
R
T
L
P
G
S
D
W
T
Site 30
S472
L
G
R
T
L
P
G
S
D
W
T
P
N
A
Q
Site 31
T475
T
L
P
G
S
D
W
T
P
N
A
Q
F
I
T
Site 32
T482
T
P
N
A
Q
F
I
T
R
S
W
L
R
D
G
Site 33
S484
N
A
Q
F
I
T
R
S
W
L
R
D
G
L
K
Site 34
T496
G
L
K
P
R
C
I
T
R
D
L
K
W
G
T
Site 35
T503
T
R
D
L
K
W
G
T
P
V
P
L
E
G
F
Site 36
S527
D
A
T
I
G
Y
L
S
I
T
A
N
Y
T
D
Site 37
T529
T
I
G
Y
L
S
I
T
A
N
Y
T
D
Q
W
Site 38
Y549
N
P
E
Q
V
D
L
Y
Q
F
M
A
K
D
N
Site 39
S579
E
D
N
Y
T
L
V
S
H
L
I
A
T
E
Y
Site 40
Y586
S
H
L
I
A
T
E
Y
L
N
Y
E
D
G
K
Site 41
Y589
I
A
T
E
Y
L
N
Y
E
D
G
K
F
S
K
Site 42
S595
N
Y
E
D
G
K
F
S
K
S
R
G
V
G
V
Site 43
S597
E
D
G
K
F
S
K
S
R
G
V
G
V
F
G
Site 44
T610
F
G
D
M
A
Q
D
T
G
I
P
A
D
I
W
Site 45
Y620
P
A
D
I
W
R
F
Y
L
L
Y
I
R
P
E
Site 46
Y623
I
W
R
F
Y
L
L
Y
I
R
P
E
G
Q
D
Site 47
S631
I
R
P
E
G
Q
D
S
A
F
S
W
T
D
L
Site 48
S634
E
G
Q
D
S
A
F
S
W
T
D
L
L
L
K
Site 49
S662
N
R
A
G
M
F
V
S
K
F
F
G
G
Y
V
Site 50
T675
Y
V
P
E
M
V
L
T
P
D
D
Q
R
L
L
Site 51
T686
Q
R
L
L
A
H
V
T
L
E
L
Q
H
Y
H
Site 52
Y692
V
T
L
E
L
Q
H
Y
H
Q
L
L
E
K
V
Site 53
S707
R
I
R
D
A
L
R
S
I
L
T
I
S
R
H
Site 54
T710
D
A
L
R
S
I
L
T
I
S
R
H
G
N
Q
Site 55
Y718
I
S
R
H
G
N
Q
Y
I
Q
V
N
E
P
W
Site 56
T740
A
D
R
Q
R
A
G
T
V
T
G
L
A
V
N
Site 57
T797
P
A
G
H
Q
I
G
T
V
S
P
L
F
Q
K
Site 58
S799
G
H
Q
I
G
T
V
S
P
L
F
Q
K
L
E
Site 59
S812
L
E
N
D
Q
I
E
S
L
R
Q
R
F
G
G
Site 60
T824
F
G
G
G
Q
A
K
T
S
P
K
P
A
V
V
Site 61
S825
G
G
G
Q
A
K
T
S
P
K
P
A
V
V
E
Site 62
T833
P
K
P
A
V
V
E
T
V
T
T
A
K
P
Q
Site 63
T836
A
V
V
E
T
V
T
T
A
K
P
Q
Q
I
Q
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation