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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
POLE2
Full Name:
DNA polymerase epsilon subunit 2
Alias:
DNA polymerase epsilon subunit B; DNA polymerase II subunit 2; DPE2; DPOE2; EC 2.7.7.7
Type:
DNA repair, DNA replication, Transferase, Nucleotide Metabolism group, Pyrimidine metabolism family, Purine metabolism family
Mass (Da):
59537
Number AA:
527
UniProt ID:
P56282
International Prot ID:
IPI00008829
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005654
Uniprot
OncoNet
Molecular Function:
GO:0003677
GO:0003887
PhosphoSite+
KinaseNET
Biological Process:
GO:0006261
GO:0006297
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S8
M
A
P
E
R
L
R
S
R
A
L
S
A
F
K
Site 2
S12
R
L
R
S
R
A
L
S
A
F
K
L
R
G
L
Site 3
Y28
L
R
G
E
A
I
K
Y
L
T
E
A
L
Q
S
Site 4
T30
G
E
A
I
K
Y
L
T
E
A
L
Q
S
I
S
Site 5
S35
Y
L
T
E
A
L
Q
S
I
S
E
L
E
L
E
Site 6
S58
A
V
E
K
Q
P
L
S
S
N
M
I
E
R
S
Site 7
S59
V
E
K
Q
P
L
S
S
N
M
I
E
R
S
V
Site 8
S65
S
S
N
M
I
E
R
S
V
V
E
A
A
V
Q
Site 9
S75
E
A
A
V
Q
E
C
S
Q
S
V
D
E
T
I
Site 10
S77
A
V
Q
E
C
S
Q
S
V
D
E
T
I
E
H
Site 11
T81
C
S
Q
S
V
D
E
T
I
E
H
V
F
N
I
Site 12
Y99
F
D
I
P
R
F
V
Y
N
S
E
R
K
K
F
Site 13
S101
I
P
R
F
V
Y
N
S
E
R
K
K
F
L
P
Site 14
T112
K
F
L
P
L
L
M
T
N
H
P
A
P
N
L
Site 15
T122
P
A
P
N
L
F
G
T
P
R
D
K
A
E
M
Site 16
Y134
A
E
M
F
R
E
R
Y
T
I
L
H
Q
R
T
Site 17
T141
Y
T
I
L
H
Q
R
T
H
R
H
E
L
F
T
Site 18
T148
T
H
R
H
E
L
F
T
P
P
V
I
G
S
H
Site 19
S154
F
T
P
P
V
I
G
S
H
P
D
E
S
G
S
Site 20
S159
I
G
S
H
P
D
E
S
G
S
K
F
Q
L
K
Site 21
T167
G
S
K
F
Q
L
K
T
I
E
T
L
L
G
S
Site 22
T170
F
Q
L
K
T
I
E
T
L
L
G
S
T
T
K
Site 23
T201
K
F
F
L
E
D
P
T
G
T
V
Q
L
D
L
Site 24
S209
G
T
V
Q
L
D
L
S
K
A
Q
F
H
S
G
Site 25
T245
N
A
F
G
F
P
P
T
E
P
S
S
T
T
R
Site 26
S248
G
F
P
P
T
E
P
S
S
T
T
R
A
Y
Y
Site 27
S249
F
P
P
T
E
P
S
S
T
T
R
A
Y
Y
G
Site 28
T250
P
P
T
E
P
S
S
T
T
R
A
Y
Y
G
N
Site 29
Y254
P
S
S
T
T
R
A
Y
Y
G
N
I
N
F
F
Site 30
Y255
S
S
T
T
R
A
Y
Y
G
N
I
N
F
F
G
Site 31
S268
F
G
G
P
S
N
T
S
V
K
T
S
A
K
L
Site 32
S272
S
N
T
S
V
K
T
S
A
K
L
K
Q
L
E
Site 33
S326
F
I
L
C
G
N
F
S
S
A
P
Y
G
K
N
Site 34
S327
I
L
C
G
N
F
S
S
A
P
Y
G
K
N
Q
Site 35
Y352
L
A
D
I
I
C
E
Y
P
D
I
H
Q
S
S
Site 36
S358
E
Y
P
D
I
H
Q
S
S
R
F
V
F
V
P
Site 37
S374
P
E
D
P
G
F
G
S
I
L
P
R
P
P
L
Site 38
Y407
T
N
P
C
R
I
Q
Y
C
T
Q
E
I
T
V
Site 39
S432
R
N
C
V
R
F
P
S
S
N
L
A
I
P
N
Site 40
S433
N
C
V
R
F
P
S
S
N
L
A
I
P
N
H
Site 41
Y465
V
C
P
V
Y
W
A
Y
D
Y
A
L
R
V
Y
Site 42
Y467
P
V
Y
W
A
Y
D
Y
A
L
R
V
Y
P
V
Site 43
T488
A
D
K
Y
D
P
F
T
T
T
N
T
E
C
L
Site 44
S505
N
P
G
S
F
P
R
S
G
F
S
F
K
V
F
Site 45
S508
S
F
P
R
S
G
F
S
F
K
V
F
Y
P
S
Site 46
Y513
G
F
S
F
K
V
F
Y
P
S
N
K
T
V
E
Site 47
S515
S
F
K
V
F
Y
P
S
N
K
T
V
E
D
S
Site 48
T518
V
F
Y
P
S
N
K
T
V
E
D
S
K
L
Q
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation