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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
KCNQ4
Full Name:
Potassium voltage-gated channel subfamily KQT member 4
Alias:
DFNA2; KQT-like 4; KV7.4; Potassium channel subunit alpha KvLQT4; Voltage-gated potassium channel Kv7.4
Type:
Voltage-gated potassium channel complex, plasma membrane, basal plasma membrane, integral to membrane
Mass (Da):
77092
Number AA:
695
UniProt ID:
P56696
International Prot ID:
IPI00293679
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0008076
Uniprot
OncoNet
Molecular Function:
GO:0030955
GO:0005249
PhosphoSite+
KinaseNET
Biological Process:
GO:0006813
GO:0007605
GO:0055085
Phosida
TranscriptoNet
STRING
Kinexus Products
Potassium voltage-gated channel subfamily KQT member 4 pan-specific antibody AB-NN276-1#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-NN276-1
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T27
R
A
E
L
V
A
L
T
A
V
Q
S
E
Q
G
Site 2
S31
V
A
L
T
A
V
Q
S
E
Q
G
E
A
G
G
Site 3
S41
G
E
A
G
G
G
G
S
P
R
R
L
G
L
L
Site 4
S50
R
R
L
G
L
L
G
S
P
L
P
P
G
A
P
Site 5
S63
A
P
L
P
G
P
G
S
G
S
G
S
A
C
G
Site 6
S65
L
P
G
P
G
S
G
S
G
S
A
C
G
Q
R
Site 7
S67
G
P
G
S
G
S
G
S
A
C
G
Q
R
S
S
Site 8
S74
S
A
C
G
Q
R
S
S
A
A
H
K
R
Y
R
Site 9
Y80
S
S
A
A
H
K
R
Y
R
R
L
Q
N
W
V
Site 10
Y88
R
R
L
Q
N
W
V
Y
N
V
L
E
R
P
R
Site 11
S201
Q
G
N
I
F
A
T
S
A
L
R
S
M
R
F
Site 12
T223
R
M
D
R
R
G
G
T
W
K
L
L
G
S
V
Site 13
S229
G
T
W
K
L
L
G
S
V
V
Y
A
H
S
K
Site 14
S235
G
S
V
V
Y
A
H
S
K
E
L
I
T
A
W
Site 15
S265
L
A
E
K
D
A
N
S
D
F
S
S
Y
A
D
Site 16
S268
K
D
A
N
S
D
F
S
S
Y
A
D
S
L
W
Site 17
S269
D
A
N
S
D
F
S
S
Y
A
D
S
L
W
W
Site 18
Y286
I
T
L
T
T
I
G
Y
G
D
K
T
P
H
T
Site 19
T290
T
I
G
Y
G
D
K
T
P
H
T
W
L
G
R
Site 20
T293
Y
G
D
K
T
P
H
T
W
L
G
R
V
L
A
Site 21
Y353
I
Q
A
A
W
R
L
Y
S
T
D
M
S
R
A
Site 22
S354
Q
A
A
W
R
L
Y
S
T
D
M
S
R
A
Y
Site 23
S358
R
L
Y
S
T
D
M
S
R
A
Y
L
T
A
T
Site 24
Y361
S
T
D
M
S
R
A
Y
L
T
A
T
W
Y
Y
Site 25
S410
P
V
P
D
G
A
P
S
R
Y
P
P
V
A
T
Site 26
Y412
P
D
G
A
P
S
R
Y
P
P
V
A
T
C
H
Site 27
T417
S
R
Y
P
P
V
A
T
C
H
R
P
G
S
T
Site 28
S423
A
T
C
H
R
P
G
S
T
S
F
C
P
G
E
Site 29
S425
C
H
R
P
G
S
T
S
F
C
P
G
E
S
S
Site 30
S431
T
S
F
C
P
G
E
S
S
R
M
G
I
K
D
Site 31
S432
S
F
C
P
G
E
S
S
R
M
G
I
K
D
R
Site 32
S444
K
D
R
I
R
M
G
S
S
Q
R
R
T
G
P
Site 33
S445
D
R
I
R
M
G
S
S
Q
R
R
T
G
P
S
Site 34
T449
M
G
S
S
Q
R
R
T
G
P
S
K
Q
H
L
Site 35
S452
S
Q
R
R
T
G
P
S
K
Q
H
L
A
P
P
Site 36
T460
K
Q
H
L
A
P
P
T
M
P
T
S
P
S
S
Site 37
T463
L
A
P
P
T
M
P
T
S
P
S
S
E
Q
V
Site 38
S464
A
P
P
T
M
P
T
S
P
S
S
E
Q
V
G
Site 39
S466
P
T
M
P
T
S
P
S
S
E
Q
V
G
E
A
Site 40
S467
T
M
P
T
S
P
S
S
E
Q
V
G
E
A
T
Site 41
S475
E
Q
V
G
E
A
T
S
P
T
K
V
Q
K
S
Site 42
T477
V
G
E
A
T
S
P
T
K
V
Q
K
S
W
S
Site 43
S482
S
P
T
K
V
Q
K
S
W
S
F
N
D
R
T
Site 44
S484
T
K
V
Q
K
S
W
S
F
N
D
R
T
R
F
Site 45
T489
S
W
S
F
N
D
R
T
R
F
R
A
S
L
R
Site 46
S494
D
R
T
R
F
R
A
S
L
R
L
K
P
R
T
Site 47
T501
S
L
R
L
K
P
R
T
S
A
E
D
A
P
S
Site 48
S502
L
R
L
K
P
R
T
S
A
E
D
A
P
S
E
Site 49
S508
T
S
A
E
D
A
P
S
E
E
V
A
E
E
K
Site 50
S516
E
E
V
A
E
E
K
S
Y
Q
C
E
L
T
V
Site 51
Y517
E
V
A
E
E
K
S
Y
Q
C
E
L
T
V
D
Site 52
T522
K
S
Y
Q
C
E
L
T
V
D
D
I
M
P
A
Site 53
T552
A
K
R
K
F
K
E
T
L
R
P
Y
D
V
K
Site 54
Y556
F
K
E
T
L
R
P
Y
D
V
K
D
V
I
E
Site 55
S578
D
M
L
G
R
I
K
S
L
Q
T
R
V
D
Q
Site 56
S646
F
Y
S
R
C
L
R
S
G
T
S
A
S
L
G
Site 57
T665
P
L
F
D
P
D
I
T
S
D
Y
H
S
P
V
Site 58
S666
L
F
D
P
D
I
T
S
D
Y
H
S
P
V
D
Site 59
Y668
D
P
D
I
T
S
D
Y
H
S
P
V
D
H
E
Site 60
S670
D
I
T
S
D
Y
H
S
P
V
D
H
E
D
I
Site 61
S678
P
V
D
H
E
D
I
S
V
S
A
Q
T
L
S
Site 62
S685
S
V
S
A
Q
T
L
S
I
S
R
S
V
S
T
Site 63
S687
S
A
Q
T
L
S
I
S
R
S
V
S
T
N
M
Site 64
S689
Q
T
L
S
I
S
R
S
V
S
T
N
M
D
_
Site 65
S691
L
S
I
S
R
S
V
S
T
N
M
D
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation