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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
P130Cas
Full Name:
Breast cancer anti-estrogen resistance protein 1
Alias:
BCA1; BCAR1; Breast cancer anti-estrogen resistance 1; Breast cancer anti-estrogen resistance 1 protein; CAS; Cas scaffolding protein family member 1; CASS1; CRKAS; CRK-associated substrate; P130cas
Type:
Adapter/scaffold protein
Mass (Da):
93372
Number AA:
870
UniProt ID:
P56945
International Prot ID:
IPI00011998
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005829
GO:0005925
GO:0005624
Uniprot
OncoNet
Molecular Function:
GO:0017124
GO:0019901
GO:0019903
PhosphoSite+
KinaseNET
Biological Process:
GO:0050853
GO:0007186
GO:0050852
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y12
N
V
L
A
K
A
L
Y
D
N
V
A
E
S
P
Site 2
S18
L
Y
D
N
V
A
E
S
P
D
E
L
S
F
R
Site 3
S23
A
E
S
P
D
E
L
S
F
R
K
G
D
I
M
Site 4
T31
F
R
K
G
D
I
M
T
V
L
E
Q
D
T
Q
Site 5
Y67
L
K
I
L
V
G
M
Y
D
K
K
P
A
G
P
Site 6
S76
K
K
P
A
G
P
G
S
G
P
P
A
T
P
A
Site 7
T81
P
G
S
G
P
P
A
T
P
A
Q
P
Q
P
G
Site 8
S97
H
A
P
A
P
P
A
S
Q
Y
T
P
M
L
P
Site 9
Y99
P
A
P
P
A
S
Q
Y
T
P
M
L
P
N
T
Site 10
T100
A
P
P
A
S
Q
Y
T
P
M
L
P
N
T
Y
Site 11
T106
Y
T
P
M
L
P
N
T
Y
Q
P
Q
P
D
S
Site 12
S113
T
Y
Q
P
Q
P
D
S
V
Y
L
V
P
T
P
Site 13
Y115
Q
P
Q
P
D
S
V
Y
L
V
P
T
P
S
K
Site 14
T119
D
S
V
Y
L
V
P
T
P
S
K
A
Q
Q
G
Site 15
S121
V
Y
L
V
P
T
P
S
K
A
Q
Q
G
L
Y
Site 16
Y128
S
K
A
Q
Q
G
L
Y
Q
V
P
G
P
S
P
Site 17
S134
L
Y
Q
V
P
G
P
S
P
Q
F
Q
S
P
P
Site 18
S139
G
P
S
P
Q
F
Q
S
P
P
A
K
Q
T
S
Site 19
S146
S
P
P
A
K
Q
T
S
T
F
S
K
Q
T
P
Site 20
T147
P
P
A
K
Q
T
S
T
F
S
K
Q
T
P
H
Site 21
S149
A
K
Q
T
S
T
F
S
K
Q
T
P
H
H
P
Site 22
T152
T
S
T
F
S
K
Q
T
P
H
H
P
F
P
S
Site 23
S159
T
P
H
H
P
F
P
S
P
A
T
D
L
Y
Q
Site 24
Y165
P
S
P
A
T
D
L
Y
Q
V
P
P
G
P
G
Site 25
Y179
G
G
P
A
Q
D
I
Y
Q
V
P
P
S
A
G
Site 26
S184
D
I
Y
Q
V
P
P
S
A
G
M
G
H
D
I
Site 27
Y192
A
G
M
G
H
D
I
Y
Q
V
P
P
S
M
D
Site 28
S197
D
I
Y
Q
V
P
P
S
M
D
T
R
S
W
E
Site 29
T200
Q
V
P
P
S
M
D
T
R
S
W
E
G
T
K
Site 30
S202
P
P
S
M
D
T
R
S
W
E
G
T
K
P
P
Site 31
T206
D
T
R
S
W
E
G
T
K
P
P
A
K
V
V
Site 32
Y222
P
T
R
V
G
Q
G
Y
V
Y
E
A
A
Q
P
Site 33
Y224
R
V
G
Q
G
Y
V
Y
E
A
A
Q
P
E
Q
Site 34
Y234
A
Q
P
E
Q
D
E
Y
D
I
P
R
H
L
L
Site 35
Y249
A
P
G
P
Q
D
I
Y
D
V
P
P
V
R
G
Site 36
S260
P
V
R
G
L
L
P
S
Q
Y
G
Q
E
V
Y
Site 37
Y262
R
G
L
L
P
S
Q
Y
G
Q
E
V
Y
D
T
Site 38
Y267
S
Q
Y
G
Q
E
V
Y
D
T
P
P
M
A
V
Site 39
T269
Y
G
Q
E
V
Y
D
T
P
P
M
A
V
K
G
Site 40
Y287
R
D
P
L
L
E
V
Y
D
V
P
P
S
V
E
Site 41
S292
E
V
Y
D
V
P
P
S
V
E
K
G
L
P
P
Site 42
S300
V
E
K
G
L
P
P
S
N
H
H
A
V
Y
D
Site 43
Y306
P
S
N
H
H
A
V
Y
D
V
P
P
S
V
S
Site 44
S311
A
V
Y
D
V
P
P
S
V
S
K
D
V
P
D
Site 45
S313
Y
D
V
P
P
S
V
S
K
D
V
P
D
G
P
Site 46
T326
G
P
L
L
R
E
E
T
Y
D
V
P
P
A
F
Site 47
Y327
P
L
L
R
E
E
T
Y
D
V
P
P
A
F
A
Site 48
S355
L
A
A
P
P
P
D
S
P
P
A
E
D
V
Y
Site 49
Y362
S
P
P
A
E
D
V
Y
D
V
P
P
P
A
P
Site 50
Y372
P
P
P
A
P
D
L
Y
D
V
P
P
G
L
R
Site 51
T385
L
R
R
P
G
P
G
T
L
Y
D
V
P
R
E
Site 52
Y387
R
P
G
P
G
T
L
Y
D
V
P
R
E
R
V
Site 53
Y410
G
V
V
D
S
G
V
Y
A
V
P
P
P
A
E
Site 54
S428
P
A
E
G
K
R
L
S
A
S
S
T
G
S
T
Site 55
S430
E
G
K
R
L
S
A
S
S
T
G
S
T
R
S
Site 56
S431
G
K
R
L
S
A
S
S
T
G
S
T
R
S
S
Site 57
T432
K
R
L
S
A
S
S
T
G
S
T
R
S
S
Q
Site 58
S434
L
S
A
S
S
T
G
S
T
R
S
S
Q
S
A
Site 59
T435
S
A
S
S
T
G
S
T
R
S
S
Q
S
A
S
Site 60
S437
S
S
T
G
S
T
R
S
S
Q
S
A
S
S
L
Site 61
S438
S
T
G
S
T
R
S
S
Q
S
A
S
S
L
E
Site 62
S440
G
S
T
R
S
S
Q
S
A
S
S
L
E
V
A
Site 63
S442
T
R
S
S
Q
S
A
S
S
L
E
V
A
G
P
Site 64
S443
R
S
S
Q
S
A
S
S
L
E
V
A
G
P
G
Site 65
T487
L
A
G
S
A
G
A
T
G
S
W
R
S
P
S
Site 66
S489
G
S
A
G
A
T
G
S
W
R
S
P
S
E
P
Site 67
S492
G
A
T
G
S
W
R
S
P
S
E
P
Q
E
P
Site 68
S494
T
G
S
W
R
S
P
S
E
P
Q
E
P
L
V
Site 69
S533
V
G
N
A
A
H
T
S
D
R
A
L
H
A
K
Site 70
S542
R
A
L
H
A
K
L
S
R
Q
L
Q
K
M
E
Site 71
T554
K
M
E
D
V
H
Q
T
L
V
A
H
G
Q
A
Site 72
S569
L
D
A
G
R
G
G
S
G
A
T
L
E
D
L
Site 73
S595
E
D
A
K
Q
L
A
S
F
L
H
G
N
A
S
Site 74
S602
S
F
L
H
G
N
A
S
L
L
F
R
R
T
K
Site 75
T608
A
S
L
L
F
R
R
T
K
A
T
A
P
G
P
Site 76
T611
L
F
R
R
T
K
A
T
A
P
G
P
E
G
G
Site 77
T620
P
G
P
E
G
G
G
T
L
H
P
N
P
T
D
Site 78
T626
G
T
L
H
P
N
P
T
D
K
T
S
S
I
Q
Site 79
T629
H
P
N
P
T
D
K
T
S
S
I
Q
S
R
P
Site 80
S630
P
N
P
T
D
K
T
S
S
I
Q
S
R
P
L
Site 81
S631
N
P
T
D
K
T
S
S
I
Q
S
R
P
L
P
Site 82
S634
D
K
T
S
S
I
Q
S
R
P
L
P
S
P
P
Site 83
S639
I
Q
S
R
P
L
P
S
P
P
K
F
T
S
Q
Site 84
S645
P
S
P
P
K
F
T
S
Q
D
S
P
D
G
Q
Site 85
S648
P
K
F
T
S
Q
D
S
P
D
G
Q
Y
E
N
Site 86
Y653
Q
D
S
P
D
G
Q
Y
E
N
S
E
G
G
W
Site 87
S656
P
D
G
Q
Y
E
N
S
E
G
G
W
M
E
D
Site 88
Y664
E
G
G
W
M
E
D
Y
D
Y
V
H
L
Q
G
Site 89
Y666
G
W
M
E
D
Y
D
Y
V
H
L
Q
G
K
E
Site 90
T678
G
K
E
E
F
E
K
T
Q
K
E
L
L
E
K
Site 91
S687
K
E
L
L
E
K
G
S
I
T
R
Q
G
K
S
Site 92
S694
S
I
T
R
Q
G
K
S
Q
L
E
L
Q
Q
L
Site 93
S712
E
R
L
E
Q
E
V
S
R
P
I
D
H
D
L
Site 94
T723
D
H
D
L
A
N
W
T
P
A
Q
P
L
A
P
Site 95
S739
R
T
G
G
L
G
P
S
D
R
Q
L
L
L
F
Site 96
Y747
D
R
Q
L
L
L
F
Y
L
E
Q
C
E
A
N
Site 97
T756
E
Q
C
E
A
N
L
T
T
L
T
N
A
V
D
Site 98
S800
V
F
I
G
D
T
L
S
R
Q
A
K
A
A
D
Site 99
S810
A
K
A
A
D
V
R
S
Q
V
T
H
Y
S
N
Site 100
Y837
T
K
A
A
A
L
Q
Y
P
S
P
S
A
A
Q
Site 101
S839
A
A
A
L
Q
Y
P
S
P
S
A
A
Q
D
M
Site 102
S856
R
V
K
E
L
G
H
S
T
Q
Q
F
R
R
V
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation