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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
HUNK
Full Name:
Hormonally up-regulated neu tumor-associated kinase
Alias:
B19; EC 2.7.11.1; MAK-V
Type:
Protein-serine kinase, CAMK group, CAMKL family, HUNK subfamily
Mass (Da):
79686
Number AA:
714
UniProt ID:
P57058
International Prot ID:
IPI00219553
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0004674
PhosphoSite+
KinaseNET
Biological Process:
GO:0007275
GO:0006468
GO:0007165
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S42
S
F
L
P
A
W
V
S
G
V
P
R
E
R
L
Site 2
Y61
H
H
K
R
V
G
N
Y
L
I
G
S
R
K
L
Site 3
S65
V
G
N
Y
L
I
G
S
R
K
L
G
E
G
S
Site 4
S72
S
R
K
L
G
E
G
S
F
A
K
V
R
E
G
Site 5
T102
K
K
R
A
K
K
D
T
Y
V
T
K
N
L
R
Site 6
Y103
K
R
A
K
K
D
T
Y
V
T
K
N
L
R
R
Site 7
S135
D
I
L
E
T
E
N
S
Y
Y
L
V
M
E
L
Site 8
Y137
L
E
T
E
N
S
Y
Y
L
V
M
E
L
C
P
Site 9
Y153
G
N
L
M
H
K
I
Y
E
K
K
R
L
E
E
Site 10
S161
E
K
K
R
L
E
E
S
E
A
R
R
Y
I
R
Site 11
Y166
E
E
S
E
A
R
R
Y
I
R
Q
L
I
S
A
Site 12
S172
R
Y
I
R
Q
L
I
S
A
V
E
H
L
H
R
Site 13
Y216
N
C
A
G
I
L
G
Y
S
D
P
F
S
T
Q
Site 14
S221
L
G
Y
S
D
P
F
S
T
Q
C
G
S
P
A
Site 15
T222
G
Y
S
D
P
F
S
T
Q
C
G
S
P
A
Y
Site 16
S226
P
F
S
T
Q
C
G
S
P
A
Y
A
A
P
E
Site 17
Y240
E
L
L
A
R
K
K
Y
G
P
K
I
D
V
W
Site 18
S269
P
F
T
V
E
P
F
S
L
R
A
L
Y
Q
K
Site 19
Y274
P
F
S
L
R
A
L
Y
Q
K
M
V
D
K
E
Site 20
Y324
N
R
W
L
N
E
N
Y
T
G
K
V
P
C
N
Site 21
Y334
K
V
P
C
N
V
T
Y
P
N
R
I
S
L
E
Site 22
S339
V
T
Y
P
N
R
I
S
L
E
D
L
S
P
S
Site 23
Y357
H
M
T
E
K
L
G
Y
K
N
S
D
V
I
N
Site 24
S360
E
K
L
G
Y
K
N
S
D
V
I
N
T
V
L
Site 25
S368
D
V
I
N
T
V
L
S
N
R
A
C
H
I
L
Site 26
Y378
A
C
H
I
L
A
I
Y
F
L
L
N
K
K
L
Site 27
Y388
L
N
K
K
L
E
R
Y
L
S
G
K
S
D
I
Site 28
S390
K
K
L
E
R
Y
L
S
G
K
S
D
I
Q
D
Site 29
S393
E
R
Y
L
S
G
K
S
D
I
Q
D
S
L
C
Site 30
S398
G
K
S
D
I
Q
D
S
L
C
Y
K
T
R
L
Site 31
Y406
L
C
Y
K
T
R
L
Y
Q
I
E
K
Y
R
A
Site 32
Y411
R
L
Y
Q
I
E
K
Y
R
A
P
K
E
S
Y
Site 33
S417
K
Y
R
A
P
K
E
S
Y
E
A
S
L
D
T
Site 34
S421
P
K
E
S
Y
E
A
S
L
D
T
W
T
R
D
Site 35
T424
S
Y
E
A
S
L
D
T
W
T
R
D
L
E
F
Site 36
S454
D
F
L
H
R
P
F
S
K
K
L
D
K
N
L
Site 37
S463
K
L
D
K
N
L
P
S
H
K
Q
P
S
G
S
Site 38
S470
S
H
K
Q
P
S
G
S
L
M
T
Q
I
Q
N
Site 39
S488
L
L
K
D
R
K
A
S
K
S
S
F
P
D
K
Site 40
S490
K
D
R
K
A
S
K
S
S
F
P
D
K
D
S
Site 41
S491
D
R
K
A
S
K
S
S
F
P
D
K
D
S
F
Site 42
S497
S
S
F
P
D
K
D
S
F
G
C
R
N
I
F
Site 43
S508
R
N
I
F
R
K
T
S
D
S
N
C
V
A
S
Site 44
S510
I
F
R
K
T
S
D
S
N
C
V
A
S
S
S
Site 45
T528
I
P
V
P
P
P
R
T
P
R
I
V
K
K
P
Site 46
S544
P
H
Q
P
G
P
G
S
T
G
I
P
H
K
E
Site 47
S561
L
M
L
D
M
V
R
S
F
E
S
V
D
R
D
Site 48
S564
D
M
V
R
S
F
E
S
V
D
R
D
D
H
V
Site 49
S575
D
D
H
V
E
V
L
S
P
S
H
H
Y
R
I
Site 50
S577
H
V
E
V
L
S
P
S
H
H
Y
R
I
L
N
Site 51
S585
H
H
Y
R
I
L
N
S
P
V
S
L
A
R
R
Site 52
S588
R
I
L
N
S
P
V
S
L
A
R
R
N
S
S
Site 53
S594
V
S
L
A
R
R
N
S
S
E
R
T
L
S
P
Site 54
S595
S
L
A
R
R
N
S
S
E
R
T
L
S
P
G
Site 55
T598
R
R
N
S
S
E
R
T
L
S
P
G
L
P
S
Site 56
S600
N
S
S
E
R
T
L
S
P
G
L
P
S
G
S
Site 57
S605
T
L
S
P
G
L
P
S
G
S
M
S
P
L
H
Site 58
S607
S
P
G
L
P
S
G
S
M
S
P
L
H
T
P
Site 59
S609
G
L
P
S
G
S
M
S
P
L
H
T
P
L
H
Site 60
S621
P
L
H
P
T
L
V
S
F
A
H
E
D
K
N
Site 61
S629
F
A
H
E
D
K
N
S
P
P
K
E
E
G
L
Site 62
S644
C
C
P
P
P
V
P
S
N
G
P
M
Q
P
L
Site 63
S653
G
P
M
Q
P
L
G
S
P
N
C
V
K
S
R
Site 64
S659
G
S
P
N
C
V
K
S
R
G
R
F
P
M
M
Site 65
S678
M
L
R
K
R
H
Q
S
L
Q
P
S
A
D
R
Site 66
S682
R
H
Q
S
L
Q
P
S
A
D
R
P
L
E
A
Site 67
S690
A
D
R
P
L
E
A
S
L
P
P
L
Q
P
L
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation