KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
GEMIN4
Full Name:
Component of gems 4
Alias:
DKFZP434B131; DKFZP434D174; Gem (nuclear organelle) associated protein 4; Gem associated protein 4; GEMI4; Gemin-4; HC56; HCAP1; HCC-associated protein 1; HHRF-1; P97
Type:
RNA binding protein
Mass (Da):
119990
Number AA:
1058
UniProt ID:
P57678
International Prot ID:
IPI00027717
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0015030
GO:0005829
GO:0005730
Uniprot
OncoNet
Molecular Function:
GO:0005515
GO:0006364
PhosphoSite+
KinaseNET
Biological Process:
GO:0006364
GO:0000387
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S37
A
L
A
E
L
T
K
S
D
W
E
R
V
G
R
Site 2
S54
V
E
A
L
R
E
I
S
S
A
A
A
H
S
Q
Site 3
S55
E
A
L
R
E
I
S
S
A
A
A
H
S
Q
P
Site 4
S60
I
S
S
A
A
A
H
S
Q
P
F
A
W
K
K
Site 5
T84
V
L
Q
P
H
P
V
T
P
S
D
T
E
T
R
Site 6
S86
Q
P
H
P
V
T
P
S
D
T
E
T
R
W
Q
Site 7
T88
H
P
V
T
P
S
D
T
E
T
R
W
Q
E
D
Site 8
T90
V
T
P
S
D
T
E
T
R
W
Q
E
D
L
F
Site 9
T149
E
R
F
L
E
H
V
T
V
D
T
S
A
E
D
Site 10
S180
H
P
Q
D
P
L
L
S
Q
F
S
A
M
A
H
Site 11
S183
D
P
L
L
S
Q
F
S
A
M
A
H
K
Y
L
Site 12
S205
H
P
P
K
R
L
R
S
D
P
D
A
C
P
T
Site 13
S228
R
G
L
T
Q
I
Q
S
R
I
L
G
P
G
R
Site 14
S261
E
D
D
P
Q
E
V
S
A
T
V
Y
L
D
K
Site 15
T263
D
P
Q
E
V
S
A
T
V
Y
L
D
K
L
A
Site 16
S274
D
K
L
A
T
V
I
S
V
W
N
S
D
T
Q
Site 17
S301
K
E
A
E
R
D
V
S
L
T
S
L
A
K
L
Site 18
T303
A
E
R
D
V
S
L
T
S
L
A
K
L
P
S
Site 19
S304
E
R
D
V
S
L
T
S
L
A
K
L
P
S
E
Site 20
S337
E
L
Q
A
V
L
R
S
S
Q
G
T
S
Y
D
Site 21
S338
L
Q
A
V
L
R
S
S
Q
G
T
S
Y
D
S
Site 22
T341
V
L
R
S
S
Q
G
T
S
Y
D
S
Y
R
L
Site 23
S342
L
R
S
S
Q
G
T
S
Y
D
S
Y
R
L
C
Site 24
Y343
R
S
S
Q
G
T
S
Y
D
S
Y
R
L
C
D
Site 25
S345
S
Q
G
T
S
Y
D
S
Y
R
L
C
D
S
L
Site 26
Y346
Q
G
T
S
Y
D
S
Y
R
L
C
D
S
L
T
Site 27
S351
D
S
Y
R
L
C
D
S
L
T
S
F
S
Q
N
Site 28
T353
Y
R
L
C
D
S
L
T
S
F
S
Q
N
A
T
Site 29
S354
R
L
C
D
S
L
T
S
F
S
Q
N
A
T
L
Site 30
S356
C
D
S
L
T
S
F
S
Q
N
A
T
L
Y
L
Site 31
T360
T
S
F
S
Q
N
A
T
L
Y
L
N
R
T
S
Site 32
Y362
F
S
Q
N
A
T
L
Y
L
N
R
T
S
L
S
Site 33
S367
T
L
Y
L
N
R
T
S
L
S
K
E
D
R
Q
Site 34
S369
Y
L
N
R
T
S
L
S
K
E
D
R
Q
V
V
Site 35
T390
V
R
D
F
L
R
K
T
S
T
V
L
K
N
R
Site 36
S391
R
D
F
L
R
K
T
S
T
V
L
K
N
R
A
Site 37
T392
D
F
L
R
K
T
S
T
V
L
K
N
R
A
L
Site 38
Y423
D
R
H
M
E
V
C
Y
I
F
A
S
E
K
K
Site 39
S443
E
W
V
A
C
L
G
S
N
R
A
L
F
R
E
Site 40
S474
A
D
R
A
I
P
E
S
Q
I
R
Q
V
I
H
Site 41
S491
L
E
C
Y
A
D
L
S
L
P
G
K
N
K
V
Site 42
S512
S
W
G
R
K
G
L
S
E
K
L
L
A
Y
V
Site 43
Y518
L
S
E
K
L
L
A
Y
V
E
G
F
Q
E
D
Site 44
T528
G
F
Q
E
D
L
N
T
T
F
N
Q
L
T
Q
Site 45
T529
F
Q
E
D
L
N
T
T
F
N
Q
L
T
Q
S
Site 46
T534
N
T
T
F
N
Q
L
T
Q
S
A
S
E
Q
G
Site 47
S536
T
F
N
Q
L
T
Q
S
A
S
E
Q
G
L
A
Site 48
S538
N
Q
L
T
Q
S
A
S
E
Q
G
L
A
K
A
Site 49
S599
E
V
Q
G
P
N
S
S
A
T
F
M
V
S
C
Site 50
T601
Q
G
P
N
S
S
A
T
F
M
V
S
C
L
K
Site 51
T617
T
V
W
M
K
F
S
T
P
K
E
E
K
Q
F
Site 52
Y687
A
N
A
C
R
E
E
Y
W
L
Q
T
C
S
P
Site 53
T691
R
E
E
Y
W
L
Q
T
C
S
P
F
P
L
L
Site 54
Y711
L
L
D
R
F
S
K
Y
W
P
L
P
K
E
K
Site 55
S722
P
K
E
K
R
C
L
S
L
D
R
K
D
L
A
Site 56
S748
S
A
N
A
E
T
F
S
P
D
V
W
I
K
S
Site 57
S755
S
P
D
V
W
I
K
S
L
S
W
L
H
R
K
Site 58
S757
D
V
W
I
K
S
L
S
W
L
H
R
K
L
E
Site 59
T769
K
L
E
Q
L
D
W
T
V
G
L
R
L
K
S
Site 60
S776
T
V
G
L
R
L
K
S
F
F
E
G
H
F
K
Site 61
S797
L
F
E
I
C
K
L
S
E
D
E
W
T
S
Q
Site 62
T802
K
L
S
E
D
E
W
T
S
Q
A
H
P
G
Y
Site 63
S803
L
S
E
D
E
W
T
S
Q
A
H
P
G
Y
G
Site 64
Y809
T
S
Q
A
H
P
G
Y
G
A
G
T
G
L
L
Site 65
T876
W
Q
R
L
H
Q
L
T
R
R
L
L
E
K
Q
Site 66
T972
Q
G
P
E
Q
D
L
T
Q
E
A
L
F
V
Y
Site 67
Y1002
P
E
V
C
E
P
L
Y
V
L
A
L
E
T
L
Site 68
Y1012
A
L
E
T
L
T
C
Y
E
T
L
S
K
T
N
Site 69
T1014
E
T
L
T
C
Y
E
T
L
S
K
T
N
P
S
Site 70
S1016
L
T
C
Y
E
T
L
S
K
T
N
P
S
V
S
Site 71
T1018
C
Y
E
T
L
S
K
T
N
P
S
V
S
S
L
Site 72
S1021
T
L
S
K
T
N
P
S
V
S
S
L
L
Q
R
Site 73
S1023
S
K
T
N
P
S
V
S
S
L
L
Q
R
A
H
Site 74
S1024
K
T
N
P
S
V
S
S
L
L
Q
R
A
H
E
Site 75
S1037
H
E
Q
R
F
L
K
S
I
A
E
G
I
G
P
Site 76
T1050
G
P
E
E
R
R
Q
T
L
L
Q
K
M
S
S
Site 77
S1056
Q
T
L
L
Q
K
M
S
S
F
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation