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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
FKSG10
Full Name:
Gasdermin-D
Alias:
DF5L; DFN5-like protein FLJ12150; FLJ12150; gasdermin D; GSDC1; GSDMDC1
Type:
Unknown function
Mass (Da):
52801
Number AA:
484
UniProt ID:
P57764
International Prot ID:
IPI00028027
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T26
G
G
E
F
I
P
V
T
S
L
Q
S
S
T
G
Site 2
S30
I
P
V
T
S
L
Q
S
S
T
G
F
Q
P
Y
Site 3
S31
P
V
T
S
L
Q
S
S
T
G
F
Q
P
Y
C
Site 4
Y37
S
S
T
G
F
Q
P
Y
C
L
V
V
R
K
P
Site 5
S45
C
L
V
V
R
K
P
S
S
S
W
F
W
K
P
Site 6
S46
L
V
V
R
K
P
S
S
S
W
F
W
K
P
R
Site 7
S47
V
V
R
K
P
S
S
S
W
F
W
K
P
R
Y
Site 8
S60
R
Y
K
C
V
N
L
S
I
K
D
I
L
E
P
Site 9
S79
P
D
V
Q
R
G
R
S
F
H
F
Y
D
A
M
Site 10
Y83
R
G
R
S
F
H
F
Y
D
A
M
D
G
Q
I
Site 11
S93
M
D
G
Q
I
Q
G
S
V
E
L
A
A
P
G
Site 12
S113
G
G
A
A
V
S
D
S
S
S
T
S
M
N
V
Site 13
S114
G
A
A
V
S
D
S
S
S
T
S
M
N
V
Y
Site 14
S115
A
A
V
S
D
S
S
S
T
S
M
N
V
Y
S
Site 15
S117
V
S
D
S
S
S
T
S
M
N
V
Y
S
L
S
Site 16
Y121
S
S
T
S
M
N
V
Y
S
L
S
V
D
P
N
Site 17
S122
S
T
S
M
N
V
Y
S
L
S
V
D
P
N
T
Site 18
S124
S
M
N
V
Y
S
L
S
V
D
P
N
T
W
Q
Site 19
T129
S
L
S
V
D
P
N
T
W
Q
T
L
L
H
E
Site 20
S152
K
V
L
Q
Q
L
R
S
R
G
D
N
V
Y
V
Site 21
Y158
R
S
R
G
D
N
V
Y
V
V
T
E
V
L
Q
Site 22
T161
G
D
N
V
Y
V
V
T
E
V
L
Q
T
Q
K
Site 23
T175
K
E
V
E
V
T
R
T
H
K
R
E
G
S
G
Site 24
S181
R
T
H
K
R
E
G
S
G
R
F
S
L
P
G
Site 25
S185
R
E
G
S
G
R
F
S
L
P
G
A
T
C
L
Site 26
S201
G
E
G
Q
G
H
L
S
Q
K
K
T
V
T
I
Site 27
T205
G
H
L
S
Q
K
K
T
V
T
I
P
S
G
S
Site 28
T239
F
P
D
K
K
Q
R
T
F
Q
P
P
A
T
G
Site 29
T245
R
T
F
Q
P
P
A
T
G
H
K
R
S
T
S
Site 30
S250
P
A
T
G
H
K
R
S
T
S
E
G
A
W
P
Site 31
T251
A
T
G
H
K
R
S
T
S
E
G
A
W
P
Q
Site 32
S252
T
G
H
K
R
S
T
S
E
G
A
W
P
Q
L
Site 33
S261
G
A
W
P
Q
L
P
S
G
L
S
M
M
R
C
Site 34
S264
P
Q
L
P
S
G
L
S
M
M
R
C
L
H
N
Site 35
T274
R
C
L
H
N
F
L
T
D
G
V
P
A
E
G
Site 36
T284
V
P
A
E
G
A
F
T
E
D
F
Q
G
L
R
Site 37
T296
G
L
R
A
E
V
E
T
I
S
K
E
L
E
L
Site 38
S298
R
A
E
V
E
T
I
S
K
E
L
E
L
L
D
Site 39
S338
E
A
L
E
Q
G
Q
S
L
G
P
V
E
P
L
Site 40
S419
S
A
P
W
Q
E
R
S
T
M
S
L
P
P
G
Site 41
T420
A
P
W
Q
E
R
S
T
M
S
L
P
P
G
L
Site 42
S422
W
Q
E
R
S
T
M
S
L
P
P
G
L
L
G
Site 43
S431
P
P
G
L
L
G
N
S
W
G
E
G
A
P
A
Site 44
T453
G
L
E
L
G
E
D
T
P
H
V
C
W
E
P
Site 45
S477
Y
A
S
L
A
L
L
S
G
L
S
Q
E
P
H
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation