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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
EEFSEC
Full Name:
Selenocysteine-specific elongation factor
Alias:
EFSEC; Elongation factor for selenoprotein translation; Elongation factor sec; Eukaryotic elongation factor, selenocysteine-tRNA-specific; SELB
Type:
Translation
Mass (Da):
65305
Number AA:
596
UniProt ID:
P57772
International Prot ID:
IPI00028050
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0005525
GO:0003924
GO:0003746
PhosphoSite+
KinaseNET
Biological Process:
GO:0006414
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T21
G
H
I
D
S
G
K
T
A
L
A
R
A
L
S
Site 2
S28
T
A
L
A
R
A
L
S
T
T
A
S
T
A
A
Site 3
T29
A
L
A
R
A
L
S
T
T
A
S
T
A
A
F
Site 4
T30
L
A
R
A
L
S
T
T
A
S
T
A
A
F
D
Site 5
S32
R
A
L
S
T
T
A
S
T
A
A
F
D
K
Q
Site 6
S42
A
F
D
K
Q
P
Q
S
R
E
R
G
I
T
L
Site 7
T48
Q
S
R
E
R
G
I
T
L
D
L
G
F
S
C
Site 8
S66
P
L
P
A
R
L
R
S
S
L
P
E
F
Q
A
Site 9
S67
L
P
A
R
L
R
S
S
L
P
E
F
Q
A
A
Site 10
T89
G
E
P
L
L
Q
V
T
L
V
D
C
P
G
H
Site 11
S127
T
K
G
M
Q
T
Q
S
A
E
C
L
V
I
G
Site 12
T170
M
T
K
K
M
Q
K
T
L
E
N
T
K
F
R
Site 13
T196
G
G
P
E
A
P
E
T
E
A
P
Q
G
I
P
Site 14
S214
E
L
L
T
S
Q
I
S
I
P
T
R
D
P
S
Site 15
T217
T
S
Q
I
S
I
P
T
R
D
P
S
G
P
F
Site 16
S221
S
I
P
T
R
D
P
S
G
P
F
L
M
S
V
Site 17
T242
K
G
Q
G
T
V
M
T
G
T
I
L
S
G
S
Site 18
T311
C
A
P
E
S
L
H
T
V
H
A
A
L
I
S
Site 19
Y324
I
S
V
E
K
I
P
Y
F
R
G
P
L
Q
T
Site 20
T331
Y
F
R
G
P
L
Q
T
K
A
K
F
H
I
T
Site 21
T338
T
K
A
K
F
H
I
T
V
G
H
E
T
V
M
Site 22
S352
M
G
R
L
M
F
F
S
P
A
P
D
N
F
D
Site 23
S366
D
Q
E
P
I
L
D
S
F
N
F
S
Q
E
Y
Site 24
S370
I
L
D
S
F
N
F
S
Q
E
Y
L
F
Q
E
Site 25
Y373
S
F
N
F
S
Q
E
Y
L
F
Q
E
Q
Y
L
Site 26
Y379
E
Y
L
F
Q
E
Q
Y
L
S
K
D
L
T
P
Site 27
S381
L
F
Q
E
Q
Y
L
S
K
D
L
T
P
A
V
Site 28
T385
Q
Y
L
S
K
D
L
T
P
A
V
T
D
N
D
Site 29
T439
R
L
D
A
D
I
H
T
N
T
C
R
L
A
F
Site 30
Y459
H
G
L
E
D
R
N
Y
A
D
S
F
L
P
R
Site 31
S462
E
D
R
N
Y
A
D
S
F
L
P
R
L
K
V
Site 32
Y486
V
E
R
A
M
D
D
Y
S
V
I
G
R
S
L
Site 33
S487
E
R
A
M
D
D
Y
S
V
I
G
R
S
L
F
Site 34
S492
D
Y
S
V
I
G
R
S
L
F
K
K
E
T
N
Site 35
T498
R
S
L
F
K
K
E
T
N
I
Q
L
F
V
G
Site 36
S511
V
G
L
K
V
H
L
S
T
G
E
L
G
I
I
Site 37
T512
G
L
K
V
H
L
S
T
G
E
L
G
I
I
D
Site 38
S520
G
E
L
G
I
I
D
S
A
F
G
Q
S
G
K
Site 39
S537
I
H
I
P
G
G
L
S
P
E
S
K
K
I
L
Site 40
S540
P
G
G
L
S
P
E
S
K
K
I
L
T
P
A
Site 41
T545
P
E
S
K
K
I
L
T
P
A
L
K
K
R
A
Site 42
S565
E
A
T
R
Q
E
E
S
A
E
R
S
E
P
S
Site 43
S569
Q
E
E
S
A
E
R
S
E
P
S
Q
H
V
V
Site 44
S572
S
A
E
R
S
E
P
S
Q
H
V
V
L
S
L
Site 45
Y584
L
S
L
T
F
K
R
Y
V
F
D
T
H
K
R
Site 46
T588
F
K
R
Y
V
F
D
T
H
K
R
M
V
Q
S
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation