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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
TREK-2
Full Name:
Potassium channel subfamily K member 10
Alias:
KCNK10; KCNKA; Outward rectifying potassium channel protein TREK-2; TREK2; TREK-2 K( ) channel subunit
Type:
Membrane, Integral membrane protein
Mass (Da):
59765
Number AA:
538
UniProt ID:
P57789
International Prot ID:
IPI00028078
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0016021
Uniprot
OncoNet
Molecular Function:
GO:0005267
GO:0030955
GO:0005244
PhosphoSite+
KinaseNET
Biological Process:
GO:0006813
GO:0007165
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S26
A
P
V
C
Q
P
K
S
A
T
N
G
Q
P
P
Site 2
T38
Q
P
P
A
P
A
P
T
P
T
P
R
L
S
I
Site 3
T40
P
A
P
A
P
T
P
T
P
R
L
S
I
S
S
Site 4
S44
P
T
P
T
P
R
L
S
I
S
S
R
A
T
V
Site 5
S47
T
P
R
L
S
I
S
S
R
A
T
V
V
A
R
Site 6
S59
V
A
R
M
E
G
T
S
Q
G
G
L
Q
T
V
Site 7
T65
T
S
Q
G
G
L
Q
T
V
M
K
W
K
T
V
Site 8
S100
L
E
Q
P
F
E
S
S
Q
K
N
T
I
A
L
Site 9
S120
L
R
D
H
V
C
V
S
P
Q
E
L
E
T
L
Site 10
S140
D
A
D
N
A
G
V
S
P
I
G
N
S
S
N
Site 11
S145
G
V
S
P
I
G
N
S
S
N
N
S
S
H
W
Site 12
S146
V
S
P
I
G
N
S
S
N
N
S
S
H
W
D
Site 13
S149
I
G
N
S
S
N
N
S
S
H
W
D
L
G
S
Site 14
S150
G
N
S
S
N
N
S
S
H
W
D
L
G
S
A
Site 15
S176
G
Y
G
N
I
A
P
S
T
E
G
G
K
I
F
Site 16
T177
Y
G
N
I
A
P
S
T
E
G
G
K
I
F
C
Site 17
S227
V
F
R
K
K
Q
V
S
Q
T
K
I
R
V
I
Site 18
Y292
G
G
N
A
G
I
N
Y
R
E
W
Y
K
P
L
Site 19
S326
G
D
W
L
R
V
L
S
K
K
T
K
E
E
V
Site 20
T354
V
T
A
E
F
R
E
T
R
R
R
L
S
V
E
Site 21
S359
R
E
T
R
R
R
L
S
V
E
I
H
D
K
L
Site 22
T371
D
K
L
Q
R
A
A
T
I
R
S
M
E
R
R
Site 23
S374
Q
R
A
A
T
I
R
S
M
E
R
R
R
L
G
Site 24
S388
G
L
D
Q
R
A
H
S
L
D
M
L
S
P
E
Site 25
S393
A
H
S
L
D
M
L
S
P
E
K
R
S
V
F
Site 26
S398
M
L
S
P
E
K
R
S
V
F
A
A
L
D
T
Site 27
S412
T
G
R
F
K
A
S
S
Q
E
S
I
N
N
R
Site 28
S415
F
K
A
S
S
Q
E
S
I
N
N
R
P
N
N
Site 29
S439
N
K
H
G
Q
G
A
S
E
D
N
I
I
N
K
Site 30
S449
N
I
I
N
K
F
G
S
T
S
R
L
T
K
R
Site 31
T454
F
G
S
T
S
R
L
T
K
R
K
N
K
D
L
Site 32
T464
K
N
K
D
L
K
K
T
L
P
E
D
V
Q
K
Site 33
Y473
P
E
D
V
Q
K
I
Y
K
T
F
R
N
Y
S
Site 34
T475
D
V
Q
K
I
Y
K
T
F
R
N
Y
S
L
D
Site 35
Y479
I
Y
K
T
F
R
N
Y
S
L
D
E
E
K
K
Site 36
S480
Y
K
T
F
R
N
Y
S
L
D
E
E
K
K
E
Site 37
S496
E
T
E
K
M
C
N
S
D
N
S
S
T
A
M
Site 38
S499
K
M
C
N
S
D
N
S
S
T
A
M
L
T
D
Site 39
T505
N
S
S
T
A
M
L
T
D
C
I
Q
Q
H
A
Site 40
T523
N
G
M
I
P
T
D
T
K
D
R
E
P
E
N
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation