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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
SESN3
Full Name:
Sestrin-3
Alias:
Type:
Mass (Da):
57291
Number AA:
492
UniProt ID:
P58005
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S7
_
M
N
R
G
G
G
S
P
S
A
A
A
N
Y
Site 2
Y14
S
P
S
A
A
A
N
Y
L
L
C
T
N
C
R
Site 3
S33
K
D
K
R
I
R
V
S
Q
P
L
T
R
G
P
Site 4
S41
Q
P
L
T
R
G
P
S
A
F
I
P
E
K
E
Site 5
T54
K
E
V
V
Q
A
N
T
V
D
E
R
T
N
F
Site 6
S67
N
F
L
V
E
E
Y
S
T
S
G
R
L
D
N
Site 7
S69
L
V
E
E
Y
S
T
S
G
R
L
D
N
I
T
Site 8
T76
S
G
R
L
D
N
I
T
Q
V
M
S
L
H
T
Site 9
Y85
V
M
S
L
H
T
Q
Y
L
E
S
F
L
R
S
Site 10
S88
L
H
T
Q
Y
L
E
S
F
L
R
S
Q
F
Y
Site 11
Y95
S
F
L
R
S
Q
F
Y
M
L
R
M
D
G
P
Site 12
Y147
E
W
L
N
G
L
E
Y
V
P
Q
R
L
K
N
Site 13
T170
A
H
R
P
W
L
I
T
K
E
H
I
Q
K
L
Site 14
T180
H
I
Q
K
L
V
K
T
G
E
N
N
W
S
L
Site 15
S186
K
T
G
E
N
N
W
S
L
P
E
L
V
H
A
Site 16
S221
P
E
R
D
P
E
I
S
N
G
F
R
L
I
S
Site 17
S247
D
N
N
I
E
N
A
S
L
S
G
S
N
F
G
Site 18
S251
E
N
A
S
L
S
G
S
N
F
G
I
V
D
S
Site 19
S282
E
R
E
D
E
E
A
S
Q
E
E
M
S
T
R
Site 20
S287
E
A
S
Q
E
E
M
S
T
R
F
E
K
E
K
Site 21
T288
A
S
Q
E
E
M
S
T
R
F
E
K
E
K
K
Site 22
S297
F
E
K
E
K
K
E
S
L
F
V
V
S
G
D
Site 23
S308
V
S
G
D
T
F
H
S
F
P
H
S
D
F
E
Site 24
S322
E
D
D
M
I
I
T
S
D
V
S
R
Y
I
E
Site 25
Y327
I
T
S
D
V
S
R
Y
I
E
D
P
G
F
G
Site 26
T348
R
G
E
E
H
L
P
T
F
R
A
Q
D
Y
T
Site 27
Y354
P
T
F
R
A
Q
D
Y
T
W
E
N
H
G
F
Site 28
Y383
D
E
K
F
R
M
V
Y
N
L
T
Y
N
T
M
Site 29
Y387
R
M
V
Y
N
L
T
Y
N
T
M
A
T
H
E
Site 30
T398
A
T
H
E
D
V
D
T
T
M
L
R
R
A
L
Site 31
T399
T
H
E
D
V
D
T
T
M
L
R
R
A
L
F
Site 32
Y417
H
C
M
F
G
I
R
Y
D
D
Y
D
Y
G
E
Site 33
Y420
F
G
I
R
Y
D
D
Y
D
Y
G
E
V
N
Q
Site 34
Y422
I
R
Y
D
D
Y
D
Y
G
E
V
N
Q
L
L
Site 35
T439
S
L
K
V
Y
I
K
T
V
T
C
Y
P
E
R
Site 36
Y443
Y
I
K
T
V
T
C
Y
P
E
R
T
T
K
R
Site 37
T447
V
T
C
Y
P
E
R
T
T
K
R
M
Y
D
S
Site 38
Y452
E
R
T
T
K
R
M
Y
D
S
Y
W
R
Q
F
Site 39
Y455
T
K
R
M
Y
D
S
Y
W
R
Q
F
K
H
S
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation