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Updated November 2019
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Protein Info
Short Name:
ADAMTS12
Full Name:
A disintegrin and metalloproteinase with thrombospondin motifs 12
Alias:
ADAM metallopeptidase with thrombospondin type 1 motif, 12; ATS12; EC 3.4.24
Type:
EC 3.4.24.-; Protease
Mass (Da):
177546
Number AA:
1593
UniProt ID:
P58397
International Prot ID:
IPI00036578
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005578
Uniprot
OncoNet
Molecular Function:
GO:0004222
GO:0008270
PhosphoSite+
KinaseNET
Biological Process:
GO:0006508
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y26
L
N
F
G
A
L
C
Y
G
R
Q
P
Q
P
G
Site 2
S63
G
P
V
R
V
D
A
S
G
H
F
L
S
Y
G
Site 3
S68
D
A
S
G
H
F
L
S
Y
G
L
H
Y
P
I
Site 4
Y73
F
L
S
Y
G
L
H
Y
P
I
T
S
S
R
R
Site 5
T76
Y
G
L
H
Y
P
I
T
S
S
R
R
K
R
D
Site 6
S77
G
L
H
Y
P
I
T
S
S
R
R
K
R
D
L
Site 7
S78
L
H
Y
P
I
T
S
S
R
R
K
R
D
L
D
Site 8
S87
R
K
R
D
L
D
G
S
E
D
W
V
Y
Y
R
Site 9
Y92
D
G
S
E
D
W
V
Y
Y
R
I
S
H
E
E
Site 10
Y93
G
S
E
D
W
V
Y
Y
R
I
S
H
E
E
K
Site 11
S114
T
V
N
Q
G
F
L
S
N
S
Y
I
M
E
K
Site 12
Y117
Q
G
F
L
S
N
S
Y
I
M
E
K
R
Y
G
Site 13
Y123
S
Y
I
M
E
K
R
Y
G
N
L
S
H
V
K
Site 14
S127
E
K
R
Y
G
N
L
S
H
V
K
M
M
A
S
Site 15
T144
P
L
C
H
L
S
G
T
V
L
Q
Q
G
T
R
Site 16
T154
Q
Q
G
T
R
V
G
T
A
A
L
S
A
C
H
Site 17
Y189
H
P
L
V
E
G
G
Y
H
P
H
I
V
Y
R
Site 18
Y195
G
Y
H
P
H
I
V
Y
R
R
Q
K
V
P
E
Site 19
T203
R
R
Q
K
V
P
E
T
K
E
P
T
C
G
L
Site 20
S213
P
T
C
G
L
K
D
S
V
N
I
S
Q
K
Q
Site 21
S217
L
K
D
S
V
N
I
S
Q
K
Q
E
L
W
R
Site 22
S234
W
E
R
H
N
L
P
S
R
S
L
S
R
R
S
Site 23
S236
R
H
N
L
P
S
R
S
L
S
R
R
S
I
S
Site 24
S238
N
L
P
S
R
S
L
S
R
R
S
I
S
K
E
Site 25
S241
S
R
S
L
S
R
R
S
I
S
K
E
R
W
V
Site 26
S243
S
L
S
R
R
S
I
S
K
E
R
W
V
E
T
Site 27
T256
E
T
L
V
V
A
D
T
K
M
I
E
Y
H
G
Site 28
T317
I
V
H
H
A
E
K
T
L
S
S
F
C
K
W
Site 29
S320
H
A
E
K
T
L
S
S
F
C
K
W
Q
K
S
Site 30
S332
Q
K
S
I
N
P
K
S
D
L
N
P
V
H
H
Site 31
T360
G
F
N
R
P
C
E
T
L
G
L
S
H
L
S
Site 32
S367
T
L
G
L
S
H
L
S
G
M
C
Q
P
H
R
Site 33
S382
S
C
N
I
N
E
D
S
G
L
P
L
A
F
T
Site 34
S397
I
A
H
E
L
G
H
S
F
G
I
Q
H
D
G
Site 35
Y417
E
P
V
G
R
H
P
Y
I
M
S
R
Q
L
Q
Site 36
T428
R
Q
L
Q
Y
D
P
T
P
L
T
W
S
K
C
Site 37
T431
Q
Y
D
P
T
P
L
T
W
S
K
C
S
E
E
Site 38
S433
D
P
T
P
L
T
W
S
K
C
S
E
E
Y
I
Site 39
Y439
W
S
K
C
S
E
E
Y
I
T
R
F
L
D
R
Site 40
S463
P
K
K
K
G
L
K
S
K
V
I
A
P
G
V
Site 41
T487
L
Q
Y
G
P
N
A
T
F
C
Q
E
V
E
N
Site 42
S509
S
V
K
G
F
C
R
S
K
L
D
A
A
A
D
Site 43
T518
L
D
A
A
A
D
G
T
Q
C
G
E
K
K
W
Site 44
T533
C
M
A
G
K
C
I
T
V
G
K
K
P
E
S
Site 45
S540
T
V
G
K
K
P
E
S
I
P
G
G
W
G
R
Site 46
S549
P
G
G
W
G
R
W
S
P
W
S
H
C
S
R
Site 47
S552
W
G
R
W
S
P
W
S
H
C
S
R
T
C
G
Site 48
S555
W
S
P
W
S
H
C
S
R
T
C
G
A
G
V
Site 49
Y580
E
P
K
F
G
G
K
Y
C
T
G
E
R
K
R
Site 50
T582
K
F
G
G
K
Y
C
T
G
E
R
K
R
Y
R
Site 51
Y588
C
T
G
E
R
K
R
Y
R
L
C
N
V
H
P
Site 52
T602
P
C
R
S
E
A
P
T
F
R
Q
M
Q
C
S
Site 53
T613
M
Q
C
S
E
F
D
T
V
P
Y
K
N
E
L
Site 54
Y616
S
E
F
D
T
V
P
Y
K
N
E
L
Y
H
W
Site 55
Y636
P
A
H
P
C
E
L
Y
C
R
P
I
D
G
Q
Site 56
Y680
C
K
M
V
G
C
D
Y
E
I
D
S
N
A
T
Site 57
S699
G
V
C
L
G
D
G
S
S
C
Q
T
V
R
K
Site 58
S700
V
C
L
G
D
G
S
S
C
Q
T
V
R
K
M
Site 59
T703
G
D
G
S
S
C
Q
T
V
R
K
M
F
K
Q
Site 60
Y716
K
Q
K
E
G
S
G
Y
V
D
I
G
L
I
P
Site 61
S745
G
N
F
L
A
I
R
S
E
D
P
E
K
Y
Y
Site 62
Y751
R
S
E
D
P
E
K
Y
Y
L
N
G
G
F
I
Site 63
Y752
S
E
D
P
E
K
Y
Y
L
N
G
G
F
I
I
Site 64
T770
G
N
Y
K
L
A
G
T
V
F
Q
Y
D
R
K
Site 65
Y774
L
A
G
T
V
F
Q
Y
D
R
K
G
D
L
E
Site 66
Y808
V
T
N
P
G
I
K
Y
E
Y
T
I
Q
K
D
Site 67
T811
P
G
I
K
Y
E
Y
T
I
Q
K
D
G
L
D
Site 68
T848
G
T
G
I
R
R
Q
T
A
H
C
I
K
K
G
Site 69
T862
G
R
G
M
V
K
A
T
F
C
D
P
E
T
Q
Site 70
T868
A
T
F
C
D
P
E
T
Q
P
N
G
R
Q
K
Site 71
T907
P
H
G
E
K
K
R
T
V
L
C
I
Q
T
M
Site 72
T924
D
E
Q
A
L
P
P
T
D
C
Q
H
L
L
K
Site 73
T934
Q
H
L
L
K
P
K
T
L
L
S
C
N
R
D
Site 74
S968
G
G
G
V
R
I
R
S
V
T
C
A
K
N
H
Site 75
T970
G
V
R
I
R
S
V
T
C
A
K
N
H
D
E
Site 76
T982
H
D
E
P
C
D
V
T
R
K
P
N
S
R
A
Site 77
S987
D
V
T
R
K
P
N
S
R
A
L
C
G
L
Q
Site 78
S998
C
G
L
Q
Q
C
P
S
S
R
R
V
L
K
P
Site 79
S999
G
L
Q
Q
C
P
S
S
R
R
V
L
K
P
N
Site 80
T1018
S
N
G
K
N
P
P
T
L
K
P
V
P
P
P
Site 81
T1026
L
K
P
V
P
P
P
T
S
R
P
R
M
L
T
Site 82
S1027
K
P
V
P
P
P
T
S
R
P
R
M
L
T
T
Site 83
T1033
T
S
R
P
R
M
L
T
T
P
T
G
P
E
S
Site 84
T1034
S
R
P
R
M
L
T
T
P
T
G
P
E
S
M
Site 85
T1036
P
R
M
L
T
T
P
T
G
P
E
S
M
S
T
Site 86
S1040
T
T
P
T
G
P
E
S
M
S
T
S
T
P
A
Site 87
S1042
P
T
G
P
E
S
M
S
T
S
T
P
A
I
S
Site 88
T1043
T
G
P
E
S
M
S
T
S
T
P
A
I
S
S
Site 89
S1044
G
P
E
S
M
S
T
S
T
P
A
I
S
S
P
Site 90
T1045
P
E
S
M
S
T
S
T
P
A
I
S
S
P
S
Site 91
S1049
S
T
S
T
P
A
I
S
S
P
S
P
T
T
A
Site 92
S1050
T
S
T
P
A
I
S
S
P
S
P
T
T
A
S
Site 93
S1052
T
P
A
I
S
S
P
S
P
T
T
A
S
K
E
Site 94
T1054
A
I
S
S
P
S
P
T
T
A
S
K
E
G
D
Site 95
S1057
S
P
S
P
T
T
A
S
K
E
G
D
L
G
G
Site 96
S1070
G
G
K
Q
W
Q
D
S
S
T
Q
P
E
L
S
Site 97
S1071
G
K
Q
W
Q
D
S
S
T
Q
P
E
L
S
S
Site 98
T1072
K
Q
W
Q
D
S
S
T
Q
P
E
L
S
S
R
Site 99
S1077
S
S
T
Q
P
E
L
S
S
R
Y
L
I
S
T
Site 100
Y1080
Q
P
E
L
S
S
R
Y
L
I
S
T
G
S
T
Site 101
S1083
L
S
S
R
Y
L
I
S
T
G
S
T
S
Q
P
Site 102
T1084
S
S
R
Y
L
I
S
T
G
S
T
S
Q
P
I
Site 103
S1086
R
Y
L
I
S
T
G
S
T
S
Q
P
I
L
T
Site 104
S1088
L
I
S
T
G
S
T
S
Q
P
I
L
T
S
Q
Site 105
T1093
S
T
S
Q
P
I
L
T
S
Q
S
L
S
I
Q
Site 106
S1094
T
S
Q
P
I
L
T
S
Q
S
L
S
I
Q
P
Site 107
S1096
Q
P
I
L
T
S
Q
S
L
S
I
Q
P
S
E
Site 108
S1098
I
L
T
S
Q
S
L
S
I
Q
P
S
E
E
N
Site 109
S1102
Q
S
L
S
I
Q
P
S
E
E
N
V
S
S
S
Site 110
S1107
Q
P
S
E
E
N
V
S
S
S
D
T
G
P
T
Site 111
S1108
P
S
E
E
N
V
S
S
S
D
T
G
P
T
S
Site 112
S1109
S
E
E
N
V
S
S
S
D
T
G
P
T
S
E
Site 113
T1111
E
N
V
S
S
S
D
T
G
P
T
S
E
G
G
Site 114
S1115
S
S
D
T
G
P
T
S
E
G
G
L
V
A
T
Site 115
S1127
V
A
T
T
T
S
G
S
G
L
S
S
S
R
N
Site 116
S1130
T
T
S
G
S
G
L
S
S
S
R
N
P
I
T
Site 117
S1131
T
S
G
S
G
L
S
S
S
R
N
P
I
T
W
Site 118
S1132
S
G
S
G
L
S
S
S
R
N
P
I
T
W
P
Site 119
T1137
S
S
S
R
N
P
I
T
W
P
V
T
P
F
Y
Site 120
T1141
N
P
I
T
W
P
V
T
P
F
Y
N
T
L
T
Site 121
Y1144
T
W
P
V
T
P
F
Y
N
T
L
T
K
G
P
Site 122
T1148
T
P
F
Y
N
T
L
T
K
G
P
E
M
E
I
Site 123
S1157
G
P
E
M
E
I
H
S
G
S
G
E
E
R
E
Site 124
T1201
M
P
L
A
P
P
L
T
P
D
L
S
R
E
S
Site 125
S1205
P
P
L
T
P
D
L
S
R
E
S
W
W
P
P
Site 126
S1208
T
P
D
L
S
R
E
S
W
W
P
P
F
S
T
Site 127
S1223
V
M
E
G
L
L
P
S
Q
R
P
T
T
S
E
Site 128
T1227
L
L
P
S
Q
R
P
T
T
S
E
T
G
T
P
Site 129
T1228
L
P
S
Q
R
P
T
T
S
E
T
G
T
P
R
Site 130
S1229
P
S
Q
R
P
T
T
S
E
T
G
T
P
R
V
Site 131
T1233
P
T
T
S
E
T
G
T
P
R
V
E
G
M
V
Site 132
T1241
P
R
V
E
G
M
V
T
E
K
P
A
N
T
L
Site 133
T1247
V
T
E
K
P
A
N
T
L
L
P
L
G
G
D
Site 134
S1280
N
N
M
N
Q
T
K
S
S
E
P
V
L
T
E
Site 135
S1281
N
M
N
Q
T
K
S
S
E
P
V
L
T
E
E
Site 136
T1286
K
S
S
E
P
V
L
T
E
E
D
A
T
S
L
Site 137
S1303
E
G
F
L
L
N
A
S
N
Y
K
Q
L
T
N
Site 138
Y1334
T
T
C
G
L
G
A
Y
W
R
R
V
E
C
S
Site 139
S1346
E
C
S
T
Q
M
D
S
D
C
A
A
I
Q
R
Site 140
S1381
S
K
C
S
R
N
C
S
G
G
F
K
I
R
E
Site 141
S1416
A
G
I
P
P
P
L
S
M
S
C
N
P
E
P
Site 142
S1418
I
P
P
P
L
S
M
S
C
N
P
E
P
C
E
Site 143
S1436
V
E
P
W
S
Q
C
S
R
S
C
G
G
G
V
Site 144
S1438
P
W
S
Q
C
S
R
S
C
G
G
G
V
Q
E
Site 145
T1458
P
G
G
L
C
D
W
T
K
R
P
T
S
T
M
Site 146
T1495
G
G
G
F
Q
K
R
T
V
Q
C
V
P
S
E
Site 147
S1501
R
T
V
Q
C
V
P
S
E
G
N
K
T
E
D
Site 148
T1506
V
P
S
E
G
N
K
T
E
D
Q
D
Q
C
L
Site 149
S1547
T
K
D
K
L
S
A
S
F
C
Q
T
L
K
A
Site 150
S1559
L
K
A
M
K
K
C
S
V
P
T
V
R
A
E
Site 151
T1577
S
C
P
Q
T
H
I
T
H
T
Q
R
Q
R
R
Site 152
T1579
P
Q
T
H
I
T
H
T
Q
R
Q
R
R
Q
R
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation