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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
NLRP6
Full Name:
NACHT, LRR and PYD domains-containing protein 6
Alias:
PYRIN-containing APAF1-like protein 5
Type:
Mass (Da):
98768
Number AA:
892
UniProt ID:
P59044
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S9
D
Q
P
E
A
P
C
S
S
T
G
P
R
L
A
Site 2
S30
L
A
A
L
E
E
L
S
Q
E
Q
L
K
R
F
Site 3
S50
D
V
G
P
D
G
R
S
I
P
W
G
R
L
E
Site 4
T84
A
L
E
V
A
R
K
T
L
K
R
A
D
A
R
Site 5
S114
L
G
S
G
T
L
L
S
V
S
E
Y
K
K
K
Site 6
S116
S
G
T
L
L
S
V
S
E
Y
K
K
K
Y
R
Site 7
Y118
T
L
L
S
V
S
E
Y
K
K
K
Y
R
E
H
Site 8
Y122
V
S
E
Y
K
K
K
Y
R
E
H
V
L
Q
L
Site 9
S140
V
K
E
R
N
A
R
S
V
K
I
T
K
R
F
Site 10
T144
N
A
R
S
V
K
I
T
K
R
F
T
K
L
L
Site 11
S177
E
P
G
R
A
R
R
S
D
T
H
T
F
N
R
Site 12
T179
G
R
A
R
R
S
D
T
H
T
F
N
R
L
F
Site 13
T181
A
R
R
S
D
T
H
T
F
N
R
L
F
R
R
Site 14
T197
E
E
G
R
R
P
L
T
V
V
L
Q
G
P
A
Site 15
T246
E
L
L
E
R
P
G
T
R
S
L
A
D
L
I
Site 16
S248
L
E
R
P
G
T
R
S
L
A
D
L
I
L
D
Site 17
T296
G
P
E
A
A
P
C
T
D
P
F
E
A
A
S
Site 18
S303
T
D
P
F
E
A
A
S
G
A
R
V
L
G
G
Site 19
S340
R
L
Q
G
R
L
C
S
P
Q
C
A
E
V
R
Site 20
S350
C
A
E
V
R
G
F
S
D
K
D
K
K
K
Y
Site 21
Y357
S
D
K
D
K
K
K
Y
F
Y
K
Y
F
R
D
Site 22
Y361
K
K
K
Y
F
Y
K
Y
F
R
D
E
R
R
A
Site 23
Y372
E
R
R
A
E
R
A
Y
R
F
V
K
E
N
E
Site 24
S409
L
E
L
G
R
D
L
S
R
T
S
K
T
T
T
Site 25
T411
L
G
R
D
L
S
R
T
S
K
T
T
T
S
V
Site 26
S412
G
R
D
L
S
R
T
S
K
T
T
T
S
V
Y
Site 27
S473
E
Q
L
E
L
R
G
S
K
V
Q
T
L
F
L
Site 28
T477
L
R
G
S
K
V
Q
T
L
F
L
S
K
K
E
Site 29
S481
K
V
Q
T
L
F
L
S
K
K
E
L
P
G
V
Site 30
T494
G
V
L
E
T
E
V
T
Y
Q
F
I
D
Q
S
Site 31
T521
E
D
G
G
V
P
R
T
A
A
G
G
V
G
T
Site 32
S538
R
G
D
A
Q
P
H
S
H
L
V
L
T
T
R
Site 33
S568
R
H
F
G
C
M
V
S
E
R
V
K
Q
E
A
Site 34
T603
G
A
K
G
L
E
D
T
E
E
P
E
E
E
E
Site 35
Y617
E
E
G
E
E
P
N
Y
P
L
E
L
L
Y
C
Site 36
Y623
N
Y
P
L
E
L
L
Y
C
L
Y
E
T
Q
E
Site 37
S689
A
Q
E
K
K
K
K
S
L
G
K
R
L
Q
A
Site 38
S697
L
G
K
R
L
Q
A
S
L
G
G
G
S
S
S
Site 39
S703
A
S
L
G
G
G
S
S
S
Q
G
T
T
K
Q
Site 40
S704
S
L
G
G
G
S
S
S
Q
G
T
T
K
Q
L
Site 41
T707
G
G
S
S
S
Q
G
T
T
K
Q
L
P
A
S
Site 42
T708
G
S
S
S
Q
G
T
T
K
Q
L
P
A
S
L
Site 43
S714
T
T
K
Q
L
P
A
S
L
L
H
P
L
F
Q
Site 44
S732
D
P
L
C
H
L
S
S
L
T
L
S
H
C
K
Site 45
S736
H
L
S
S
L
T
L
S
H
C
K
L
P
D
A
Site 46
S749
D
A
V
C
R
D
L
S
E
A
L
R
A
A
P
Site 47
S777
E
A
G
L
R
M
L
S
E
G
L
A
W
P
Q
Site 48
T789
W
P
Q
C
R
V
Q
T
V
R
V
Q
L
P
D
Site 49
Y803
D
P
Q
R
G
L
Q
Y
L
V
G
M
L
R
Q
Site 50
T816
R
Q
S
P
A
L
T
T
L
D
L
S
G
C
Q
Site 51
S850
L
Q
T
L
S
L
A
S
V
E
L
S
E
Q
S
Site 52
S854
S
L
A
S
V
E
L
S
E
Q
S
L
Q
E
L
Site 53
S857
S
V
E
L
S
E
Q
S
L
Q
E
L
Q
A
V
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation